Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

(2021) Jiucui Li et al.   Journal of Translational Medicine

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

(2020) Pengfei Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

(2020) Yingchuan Li et al.   CELL DEATH AND DIFFERENTIATION

Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction

(2020) Jinyao Jiang et al.   Redox Biology

4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation

(2020) Yang Li et al.   Drug Design Development and Therapy

Neutrophils Disturb Pulmonary Microcirculation in Sepsis-induced Acute Lung Injury

(2019) Inwon Park et al.   EUROPEAN RESPIRATORY JOURNAL

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3

(2019) Ning Li et al.   Redox Biology

Role of ferroptosis in the process of acute radiation-induced lung injury in mice

(2019) Xuan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers

(2019) Eikan Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

(2018) David Olagnier et al.   Nature Communications

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

(2018) Hua Liu et al.   Cell Communication and Signaling

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Alveolar Macrophages from Septic Mice Promote Polymorphonuclear Leukocyte Transendothelial Migration via an Endothelial Cell Src Kinase/NADPH Oxidase Pathway

(2014) Z. Wang et al.   JOURNAL OF IMMUNOLOGY

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES