Targeted Microglial Attenuation through Dendrimer–Drug Conjugates Improves Glaucoma Neuroprotection

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Glaucoma and neuroinflammation: an overview

(2021) Luciano Quaranta et al.   SURVEY OF OPHTHALMOLOGY

The Role of Neuroinflammation in Glaucoma: An Update on Molecular Mechanisms and New Therapeutic Options

(2021) Teresa Rolle et al.   Frontiers in Neurology

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

(2021) Jong-Sung Park et al.   Acta Neuropathologica Communications

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

(2021) Henry T. Hsueh et al.   Pharmaceutics

Myeloid cells in retinal and brain degeneration

(2021) Michelle Guo et al.   FEBS Journal

Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration

(2021) Siva P. Kambhampati et al.   JOURNAL OF CONTROLLED RELEASE

Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic

(2021) Maria Francesca Cordeiro et al.   PROGRESS IN RETINAL AND EYE RESEARCH

N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)

(2021) Gerry K. Schwalfenberg   Journal of Nutrition and Metabolism

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

(2020) James R. Tribble et al.   Molecular Brain

Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model

(2020) Zhi Zhang et al.   Journal of Neuroinflammation

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

(2020) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Quantitative assessment of surface functionality effects on microglial uptake and retention of PAMAM dendrimers

(2018) Kevin Liaw et al.   JOURNAL OF NANOPARTICLE RESEARCH

Correction to: Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome

(2018) Elizabeth Nance et al.   Journal of Neuroinflammation

Expression and activation of mitogen-activated protein kinases in the optic nerve head in a rat model of ocular hypertension

(2018) Teresa Mammone et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture

(2018) Yossef Alnasser et al.   MOLECULES

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Subconjunctival dendrimer-drug therapy for the treatment of dry eye in a rabbit model of induced autoimmune dacryoadenitis

(2018) Hui Lin et al.   Ocular Surface

Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP–Glaucoma

(2018) Ian Pitha et al.   Translational Vision Science & Technology

Dendrimer-N-acetyl-L-cysteine modulates monophagocytic response in adrenoleukodystrophy

(2018) Bela R. Turk et al.   ANNALS OF NEUROLOGY

CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma

(2018) Milica A. Margeta et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome

(2017) Elizabeth Nance et al.   Journal of Neuroinflammation

Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia

(2017) Christina L. Nemeth et al.   Nanomedicine-Nanotechnology Biology and Medicine

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma

(2016) Alejandra Bosco et al.   EXPERIMENTAL EYE RESEARCH

Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy

(2016) Yan Guo et al.   PLoS One

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

(2015) A. Bosco et al.   Disease Models & Mechanisms

Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury

(2015) Elizabeth Nance et al.   JOURNAL OF CONTROLLED RELEASE

Retinal microglia: Just bystander or target for therapy?

(2015) Marcus Karlstetter et al.   PROGRESS IN RETINAL AND EYE RESEARCH

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

(2015) Alejandra Bosco et al.   Jove-Journal of Visualized Experiments

Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest

(2014) Manoj K. Mishra et al.   ACS Nano

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Dendrimer Nanoparticles for Ocular Drug Delivery

(2013) Siva P. Kambhampati et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Biodistribution of Fluorescently Labeled PAMAM Dendrimers in Neonatal Rabbits: Effect of Neuroinflammation

(2013) Wojciech G. Lesniak et al.   MOLECULAR PHARMACEUTICS

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

(2012) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement

(2012) Elma E. Chang et al.   OPHTHALMOLOGY

An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation

(2012) Masamitsu Shimazawa et al.   PLoS One

Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma

(2012) Miin Roh et al.   PLoS One

Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model

(2012) S. Kannan et al.   Science Translational Medicine

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

(2010) Anupa R. Menjoge et al.   DRUG DISCOVERY TODAY

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Poly(amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery

(2009) Yunus E. Kurtoglu et al.   BIOMATERIALS

Anti-inflammatory and anti-oxidant activity of anionic dendrimer–N-acetyl cysteine conjugates in activated microglial cells

(2009) Bing Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS