Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome

Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia

(2017) Christina L. Nemeth et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoscale effects in dendrimer-mediated targeting of neuroinflammation

(2016) Elizabeth Nance et al.   BIOMATERIALS

Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients

(2016) Alessandra Pecorelli et al.   CYTOKINE

OxInflammation in Rett syndrome

(2016) Alessandra Pecorelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enhancement of postsynaptic GABAA and extrasynaptic NMDA receptor-mediated responses in the barrel cortex of Mecp2-null mice

(2016) Fu-Sun Lo et al.   JOURNAL OF NEUROPHYSIOLOGY

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

(2016) Noriyuki Kishi et al.   Nature Communications

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

(2016) Dorothy P Schafer et al.   eLife

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

(2015) James C. Cronk et al.   IMMUNITY

Perioperative management and outcome of patients with Rett syndrome undergoing scoliosis surgery: a retrospective review

(2015) Iosifina Karmaniolou et al.   Journal of Anesthesia

Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome

(2015) Michael Bauer et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury

(2015) Elizabeth Nance et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of SystemXc−Transporter Attenuates Autoimmune Inflammatory Demyelination

(2015) Kirsten S. Evonuk et al.   JOURNAL OF IMMUNOLOGY

Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

(2015) Kirti V. Sawant et al.   Journal of Innate Immunity

Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells

(2015) Panagiotis Mastorakos et al.   Nanoscale

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

(2015) Jieqi Wang et al.   NATURE

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

(2015) Deepmala et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion

(2015) L Sleire et al.   ONCOGENE

Cytokine Dysregulation inMECP2- andCDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, andω-3 PUFAs

(2015) Silvia Leoncini et al.   Oxidative Medicine and Cellular Longevity

Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study.

(2015) Bernard Schmitt et al.   Redox Biology

Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest

(2014) Manoj K. Mishra et al.   ACS Nano

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

N-Acetylcysteine Supplementation Reduces Oxidative Stress and DNA Damage in Children with β-Thalassemia

(2014) Zeynep Canan Ozdemir et al.   HEMOGLOBIN

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome

(2014) Claudio De Felice et al.   NEUROBIOLOGY OF DISEASE

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

(2014) Reza Bavarsad Shahripour et al.   Brain and Behavior

N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine

(2013) K. Sunitha et al.   FREE RADICAL RESEARCH

Expression of CXCL1 in human endothelial cells induces angiogenesis through the CXCR2 receptor and the ERK1/2 and EGF pathways

(2013) Makito Miyake et al.   LABORATORY INVESTIGATION

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism

(2012) Antonio Y. Hardan et al.   BIOLOGICAL PSYCHIATRY

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

Serum Cytokines in a Clinical Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy

(2012) Dorothea D Jenkins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interaction of N-acetylcysteine and Cysteine in Human Plasma

(2012) Kendra K. Radtke et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

IL-12 family cytokines: immunological playmakers

(2012) Dario A A Vignali et al.   NATURE IMMUNOLOGY

Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model

(2012) S. Kannan et al.   Science Translational Medicine

Temporal and Regional Alterations in NMDA Receptor Expression in Mecp2-Null Mice

(2011) Mary E. Blue et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

(2011) Bredford Kerr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers

(2011) Jason Allen et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles

(2011) Khaled Greish et al.   Nanotoxicology

Rett syndrome: Revised diagnostic criteria and nomenclature

(2010) Jeffrey L. Neul et al.   ANNALS OF NEUROLOGY

Rett syndrome diagnostic criteria: Lessons from the Natural History Study

(2010) Alan K. Percy et al.   ANNALS OF NEUROLOGY

Comparative Biodistribution of PAMAM Dendrimers and HPMA Copolymers in Ovarian-Tumor-Bearing Mice

(2010) S. Sadekar et al.   BIOMACROMOLECULES

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Dendrimer Internalization and Intracellular Trafficking in Living Cells

(2010) Lorenzo Albertazzi et al.   MOLECULAR PHARMACEUTICS

Brain metabolism in rett syndrome: Age, clinical, and genotype correlations

(2009) Alena Horská et al.   ANNALS OF NEUROLOGY

Poly(amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery

(2009) Yunus E. Kurtoglu et al.   BIOMATERIALS

Systemic oxidative stress in classic Rett syndrome

(2009) Claudio De Felice et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-inflammatory and anti-oxidant activity of anionic dendrimer–N-acetyl cysteine conjugates in activated microglial cells

(2009) Bing Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dendrimer−Drug Conjugates for Tailored Intracellular Drug Release Based on Glutathione Levels

(2008) Raghavendra S. Navath et al.   BIOCONJUGATE CHEMISTRY

The effect of surface functionality on cellular trafficking of dendrimers

(2008) Omathanu P. Perumal et al.   BIOMATERIALS

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

(2008) Mathilde Gavillet et al.   GLIA

Induction of lymphotoxin-α by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70

(2008) Malabendu Jana et al.   IMMUNOLOGY

Endocytosis Inhibitors Prevent Poly(amidoamine) Dendrimer Internalization and Permeability across Caco-2 Cells

(2008) Kelly M. Kitchens et al.   MOLECULAR PHARMACEUTICS

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE