Myeloid cells in retinal and brain degeneration

Does tissue imprinting restrict macrophage plasticity?

(2021) Martin Guilliams et al.   NATURE IMMUNOLOGY

When Is a Control Not a Control? Reactive Microglia Occur Throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma

(2021) James R. Tribble et al.   Translational Vision Science & Technology

Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling

(2021) Peter Wieghofer et al.   EMBO JOURNAL

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis

(2021) Yi Hsing Chen et al.   Journal of Neuroinflammation

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets

(2021) Mariana Y. García-Bermúdez et al.   Frontiers in Neurology

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

(2021) Jong-Sung Park et al.   Acta Neuropathologica Communications

Glucagon-like peptide 1 receptor agonist use is associated with reduced risk for glaucoma

(2021) Jacob Sterling et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Increased Neuroprotective Microglia and Photoreceptor Survival in the Retina from a Peptide Inhibitor of Myeloid Differentiation Factor 88 (MyD88)

(2020) Kimberly Garces et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

(2020) Irune Diaz-Aparicio et al.   JOURNAL OF NEUROSCIENCE

Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

(2020) Yves Werner et al.   NATURE NEUROSCIENCE

Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome

(2020) Cheng Peng et al.   Frontiers in Immunology

GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

(2020) Katharina Timper et al.   Cell Metabolism

Peripheral blood CD163(+) monocytes and soluble CD163 in dry and neovascular age‐related macular degeneration

(2020) Narsis Daftarian et al.   FASEB JOURNAL

Exosomal MiRNA Transfer between Retinal Microglia and RPE

(2020) Dorothea R. Morris et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sub-region-Specific Optic Nerve Head Glial Activation in Glaucoma

(2020) Kazuya Oikawa et al.   MOLECULAR NEUROBIOLOGY

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

(2020) James R. Tribble et al.   Molecular Brain

True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

(2020) Francisco M Nadal-Nicolás et al.   eLife

Diagnostic Biomarkers for Alzheimer’s Disease Using Non-Invasive Specimens

(2020) Maria Paraskevaidi et al.   Journal of Clinical Medicine

Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

(2020) Tali Cukierman-Yaffe et al.   LANCET NEUROLOGY

Abundance and multimodal visibility of soft drusen in early age-related macular degeneration

(2020) Ling Chen et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

(2020) Kevin A. Guttenplan et al.   Cell Reports

The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination

(2020) Fanny Beguier et al.   IMMUNITY

Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma

(2020) Xiangjun Yang et al.   Journal of Neuroinflammation

Complement-Mediated Microglial Phagocytosis and Pathological Changes in the Development and Degeneration of the Visual System

(2020) Davis M. Borucki et al.   Frontiers in Immunology

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration

(2020) Karis Little et al.   Journal of Neuroinflammation

Characterization of Retinal Microvascular and Choroidal Structural Changes in Parkinson Disease

(2020) Cason B. Robbins et al.   JAMA Ophthalmology

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

(2019) Pete A. Williams et al.   Molecular Neurodegeneration

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

(2019) Emily G. O’Koren et al.   IMMUNITY

Retinal microglia initiate neuroinflammation in ocular autoimmunity

(2019) Yoko Okunuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)

(2019) Grazia Daniela Femminella et al.   Trials

PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes

(2019) Vanita R. Aroda et al.   DIABETES CARE

Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer’s Disease and Multiple Sclerosis

(2019) Adham Fani Maleki et al.   Frontiers in Cellular Neuroscience

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

(2019) Yvette Wooff et al.   Frontiers in Immunology

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis

(2019) Alfonso Grimaldi et al.   Frontiers in Neuroscience

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

(2019) Yilong Shan et al.   Journal of Neuroinflammation

Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate

(2019) Wendi S. Lambert et al.   Scientific Reports

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

(2019) Søren L Kristensen et al.   Lancet Diabetes & Endocrinology

Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial

(2019) Peter A. Campochiaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

(2019) Sabrina Reinehr et al.   Frontiers in Pharmacology

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Autoimmunity, Autoinflammation, and Infection in Uveitis

(2018) John V. Forrester et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

The Role of Microglia and Peripheral Monocytes in Retinal Damage after Corneal Chemical Injury

(2018) Eleftherios I. Paschalis et al.   AMERICAN JOURNAL OF PATHOLOGY

Resveratrol induces dynamic changes to the microglia transcriptome, inhibiting inflammatory pathways and protecting against microglia-mediated photoreceptor apoptosis

(2018) Johanna Wiedemann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macula segmentation and fovea localization employing image processing and heuristic based clustering for automated retinal screening

(2018) GeethaRamani R. et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Glucagon-like peptide-1 receptor expression in the human eye

(2018) Josephine B. Hebsgaard et al.   DIABETES OBESITY & METABOLISM

Cellular regeneration strategies for macular degeneration: past, present and future

(2018) Valeria Chichagova et al.   EYE

Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury

(2018) Geoffrey T. Norris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Minocycline promotes post-hemorrhagic neurogenesis via M2 microglia polarization via up-regulation of the TrkB/BDNF pathway in rats

(2018) Miao Hongsheng et al.   JOURNAL OF NEUROPHYSIOLOGY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

(2018) Yoko Okunuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal microglia – A key player in healthy and diseased retina

(2018) Gurugirijha Rathnasamy et al.   PROGRESS IN NEUROBIOLOGY

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model

(2018) Alfonso Grimaldi et al.   Cell Death & Disease

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro

(2018) M. H. Madeira et al.   Scientific Reports

Microglia in the Retina: Roles in Development, Maturity, and Disease

(2018) Sean M. Silverman et al.   Annual Review of Vision Science

CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma

(2018) Milica A. Margeta et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Choroidal Thinning as a New Finding in Alzheimer's Disease: Evidence from Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography

(2018) Magda Gharbiya et al.   JOURNAL OF ALZHEIMERS DISEASE

Optic nerve as a source of activated retinal microglia post-injury

(2018) Neal D. Heuss et al.   Acta Neuropathologica Communications

Developmental and Functional Heterogeneity of Monocytes

(2018) Martin Guilliams et al.   IMMUNITY

Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation

(2018) Despina Kokona et al.   Journal of Neuroinflammation

Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease

(2018) Najiba Mammadova et al.   NEUROBIOLOGY OF DISEASE

The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages

(2018) David A. Hume et al.   TRENDS IN IMMUNOLOGY

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

(2018) Harald Lund et al.   Nature Communications

Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer’s disease

(2018) Domingo Sánchez et al.   Scientific Reports

Visual dysfunction and its correlation with retinal changes in patients with Alzheimer's disease

(2017) V Polo et al.   EYE

Biomarkers for glaucoma: from the lab to the clinic

(2017) N Von Thun Und Hohenstein-Blaul et al.   EYE

Brain metabolic sensing and metabolic signaling at the level of an astrocyte

(2017) Nephtali Marina et al.   GLIA

Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

(2017) Bertrand Calippe et al.   IMMUNITY

Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration

(2017) Xu Wang et al.   JOURNAL OF NEUROSCIENCE

Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

(2017) Dilan Athauda et al.   LANCET

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration

(2017) Benjamin J. Kim et al.   NEUROLOGY

On phagocytes and macular degeneration

(2017) Xavier Guillonneau et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation

(2017) Qiu-Shuang Zhang et al.   TOXICOLOGY LETTERS

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

(2017) Han-Chang Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease

(2017) Yazhou Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Ocular Biomarkers for Early Detection of Alzheimer's Disease

(2017) Shaun Frost et al.   JOURNAL OF ALZHEIMERS DISEASE

Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications

(2017) Daniel Ferreira et al.   Scientific Reports

Visual function alterations in Alzheimer Disease: A case report

(2016) David Pablo Piñero et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

(2016) Dilan Athauda et al.   DRUG DISCOVERY TODAY

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

(2016) Ashley N. Nilson et al.   JOURNAL OF ALZHEIMERS DISEASE

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma

(2016) Anitha Krishnan et al.   JOURNAL OF IMMUNOLOGY

Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma

(2016) Oliver W. Gramlich et al.   Journal of Neuroinflammation

Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance

(2016) D. J. Reiner et al.   JOURNAL OF NEUROSCIENCE

Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina

(2016) Xu Wang et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

(2016) Pete A. Williams et al.   Molecular Neurodegeneration

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glia–neuron interactions in the mammalian retina

(2016) Elena Vecino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Subretinal mononuclear phagocytes induce cone segment loss via IL-1β

(2016) Chiara M Eandi et al.   eLife

Longitudinal Intravital Imaging of the Retina Reveals Long-term Dynamics of Immune Infiltration and Its Effects on the Glial Network in Experimental Autoimmune Uveoretinitis, without Evident Signs of Neuronal Dysfunction in the Ganglion Cell Layer

(2016) Daniel Bremer et al.   Frontiers in Immunology

Melanopsin retinal ganglion cell loss in Alzheimer disease

(2015) Chiara La Morgia et al.   ANNALS OF NEUROLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

(2015) L. Zhao et al.   EMBO Molecular Medicine

Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats

(2015) Volkan Solmaz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function

(2015) Jennifer L. Kielczewski et al.   JOURNAL OF IMMUNOLOGY

Parainflammation, chronic inflammation, and age-related macular degeneration

(2015) M. Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In vivo multi-modal imaging of experimental autoimmune uveoretinitis in transgenic reporter mice reveals the dynamic nature of inflammatory changes during disease progression

(2015) Xiangting Chen et al.   Journal of Neuroinflammation

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration

(2015) Rebecca Scholz et al.   Journal of Neuroinflammation

Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1  Secretion and Photoreceptor Neurodegeneration

(2015) S. J. Hu et al.   JOURNAL OF NEUROSCIENCE

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

(2015) J. L. Cueva Vargas et al.   JOURNAL OF NEUROSCIENCE

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

(2015) W. Liu et al.   NEUROSCIENCE

Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV)

(2015) Min Zhao et al.   PLoS One

Retinal microglia: Just bystander or target for therapy?

(2015) Marcus Karlstetter et al.   PROGRESS IN RETINAL AND EYE RESEARCH

IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis

(2015) Rei Nakamura et al.   Nature Communications

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation

(2015) Sonia George et al.   Journal of Parkinsons Disease

Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1βas a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients

(2015) Lukasz Markiewicz et al.   Biomed Research International

The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis

(2015) Jessica E. Potts et al.   PLoS One

A Comparison of Some Organizational Characteristics of the Mouse Central Retina and the Human Macula

(2015) Stefanie Volland et al.   PLoS One

α-synuclein in the inner retina in parkinson disease

(2014) Ivan Bodis-Wollner et al.   ANNALS OF NEUROLOGY

Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose

(2014) Matthew R. Hayes et al.   Annual Review of Nutrition

Reliability and validity of Cirrus and Spectralis optical coherence tomography for detecting retinal atrophy in Alzheimer’s disease

(2014) V Polo et al.   EYE

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Harmonized diagnostic criteria for Alzheimer's disease: recommendations

(2014) J. C. Morris et al.   JOURNAL OF INTERNAL MEDICINE

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

(2014) Hugo González et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers

(2014) Blanca Rojas et al.   Journal of Neuroinflammation

Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity

(2014) N. Gong et al.   JOURNAL OF NEUROSCIENCE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

(2014) Gareth R. Howell et al.   NEUROBIOLOGY OF DISEASE

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Macular Thickness as a Potential Biomarker of Mild Alzheimer's Disease

(2014) Elena S. Garcia-Martin et al.   OPHTHALMOLOGY

Diabetes Mellitus as a Risk Factor for Open-Angle Glaucoma: A Systematic Review and Meta-Analysis

(2014) Minwen Zhou et al.   PLoS One

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases

(2014) Nicolás Cuenca et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Detection of Retinal Nerve Fiber Layer Defects in Alzheimer’s Disease Using SD-OCT

(2014) Robert Kromer et al.   Frontiers in Psychiatry

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Exenatide and the treatment of patients with Parkinson’s disease

(2013) Iciar Aviles-Olmos et al.   JOURNAL OF CLINICAL INVESTIGATION

Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

(2013) Matt Rutar et al.   Journal of Neuroinflammation

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

(2013) Catarina Gomes et al.   Journal of Neuroinflammation

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials

(2013) Ebenezer Daniel et al.   OPHTHALMOLOGY

Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice

(2013) Christian Schön et al.   PLoS One

Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

(2012) Stephen F.J. McGovern et al.   BRAIN RESEARCH

Analysis of Systemic Endothelin-1, Matrix Metalloproteinase-9, Macrophage Chemoattractant Protein-1, and High-Sensitivity C-Reactive Protein in Normal-Tension Glaucoma

(2012) Na Young Lee et al.   CURRENT EYE RESEARCH

Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK–eNOS pathways

(2012) Lina Han et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa

(2012) Congrong Guo et al.   EXPERIMENTAL EYE RESEARCH

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia

(2012) Shuwen Cao et al.   Journal of Neuroinflammation

Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision

(2012) C. R. Jackson et al.   JOURNAL OF NEUROSCIENCE

Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: a prospective cohort study

(2012) T. Ahern et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The retina as a window to the brain—from eye research to CNS disorders

(2012) Anat London et al.   Nature Reviews Neurology

Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

(2012) Wei-Na Han et al.   NEUROBIOLOGY OF AGING

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Laboratory Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Clinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Role of Fractalkine/CX3CR1 Interaction in Light-Induced Photoreceptor Degeneration through Regulating Retinal Microglial Activation and Migration

(2012) Meng Zhang et al.   PLoS One

Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma

(2012) Miin Roh et al.   PLoS One

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei

(2012) Shuang Zhang et al.   PLoS One

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Glaucoma

(2011) Harry A Quigley   LANCET

Anatomy and physiology of the human eye: effects of mucopolysaccharidoses disease on structure and function - a review

(2010) Colin E Willoughby et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

(2010) M. Arakawa et al.   DIABETES

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

(2010) D. W. Porter et al.   DIABETES OBESITY & METABOLISM

Morphologic Changes and Functional Retinal Impairment in Patients with Parkinson Disease without Visual Loss

(2010) Marilita M. Moschos et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-acetylcysteine promotes long-term survival of cones in a model of retinitis pigmentosa

(2010) Sun Young Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

(2010) Simon Gengler et al.   NEUROBIOLOGY OF AGING

Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

(2010) X.H. Wang et al.   NEUROSCIENCE

DRUSEN CHARACTERIZATION WITH MULTIMODAL IMAGING

(2010) Richard F Spaide et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

(2009) Bingqian Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

The retina in Parkinson's disease

(2009) N. K. Archibald et al.   BRAIN

Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

(2009) Sehee Kim et al.   JOURNAL OF ENDOCRINOLOGY

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease: Visual system review

(2009) Denise A. Valenti   OPTOMETRY

Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration

(2008) Wen Chen et al.   EXPERIMENTAL EYE RESEARCH

Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease

(2008) Alexander Harkavyi et al.   Journal of Neuroinflammation

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Risk Factors for Glaucoma Onset and Progression

(2008) Anne L. Coleman et al.   SURVEY OF OPHTHALMOLOGY

Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of parkinson's disease

(2007) Göran Bertilsson et al.   JOURNAL OF NEUROSCIENCE RESEARCH