p53 regulates cytoskeleton remodeling to suppress tumor progression

Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

(2015) Eun Mi Kim et al.   Oncotarget

A Novel PTEN/Mutant p53/c-Myc/Bcl-XL Axis Mediates Context-Dependent Oncogenic Effects of PTEN with Implications for Cancer Prognosis and Therapy

(2015) Xiaoping Huang et al.   NEOPLASIA

Cellular traction stresses mediate extracellular matrix degradation by invadopodia

(2014) Rachel J. Jerrell et al.   Acta Biomaterialia

Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer

(2014) Yun Liao et al.   BMC CANCER

Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion

(2014) J. Kim et al.   EMBO REPORTS

Understanding p53: new insights into tumor suppression

(2014) Keiko Kawauchi et al.   Expert Review of Anticancer Therapy

p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion

(2014) Shota Yamauchi et al.   JOURNAL OF CELL BIOLOGY

Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis

(2014) Antti Arjonen et al.   JOURNAL OF CLINICAL INVESTIGATION

The downregulation of miR-200c/141 promotes ZEB1/2 expression and gastric cancer progression

(2014) Xinliang Zhou et al.   MEDICAL ONCOLOGY

14-3-3  Promotes Breast Cancer Invasion and Metastasis by Inhibiting RhoGDI 

(2014) Y. Xiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53  is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

(2014) S. Senturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct in Vivo RNAi Screen Unveils Myosin IIa as a Tumor Suppressor of Squamous Cell Carcinomas

(2014) D. Schramek et al.   SCIENCE

Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells

(2014) Jelena Krstic et al.   TheScientificWorldJOURNAL

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

(2014) Jose L. Orgaz et al.   Nature Communications

Contribution of p53 to Metastasis

(2014) E. Powell et al.   Cancer Discovery

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells

(2013) Hana Janouskova et al.   CANCER LETTERS

Actin filament dynamics impacts keratinocyte stem cell maintenance

(2013) Daisuke Nanba et al.   EMBO Molecular Medicine

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion

(2013) Vivek A Rudrapatna et al.   EMBO REPORTS

Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma

(2013) Hui Wang et al.   FEBS LETTERS

The Consequence of Oncomorphic TP53 Mutations in Ovarian Cancer

(2013) Pavla Brachova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutant p53 Regulates Dicer through p63-dependent and -independent Mechanisms to Promote an Invasive Phenotype

(2013) Patricia A. J. Muller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex

(2013) Guillaume Jacquemet et al.   JOURNAL OF CELL BIOLOGY

At the leading edge of three-dimensional cell migration

(2013) R. J. Petrie et al.   JOURNAL OF CELL SCIENCE

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

(2013) G. Jacquemet et al.   JOURNAL OF CELL SCIENCE

Mechanosensitive systems at the cadherin-F-actin interface

(2013) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Loss of p53 Enhances NF-κB-Dependent Lamellipodia Formation

(2013) Alvin Kunyao Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

Activation of p53–p21 is closely associated with the acquisition of resistance to apoptosis caused by β1-integrin silencing in head and neck cancer cells

(2012) Mi Ra Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Integrin  5 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

(2012) H. Janouskova et al.   CANCER RESEARCH

Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation

(2012) L. Yi et al.   CANCER RESEARCH

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

(2012) Cynthia R Coffill et al.   EMBO REPORTS

Surf the Post-translational Modification Network of p53 Regulation

(2012) Bo Gu et al.   International Journal of Biological Sciences

Involvement of S100A14 Protein in Cell Invasion by Affecting Expression and Function of Matrix Metalloproteinase (MMP)-2 via p53-dependent Transcriptional Regulation

(2012) Hongyan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

N-cadherin-mediated cell-cell adhesion promotes cell migration in a three-dimensional matrix

(2012) W. Shih et al.   JOURNAL OF CELL SCIENCE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARγ-targeted therapy

(2012) I Jagan et al.   ONCOGENE

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Overexpression of Snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells

(2012) Fan Fan et al.   Cancer Medicine

p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity

(2011) Catherine A. Vaughan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Notch signalling in cancer progression and bone metastasis

(2011) N Sethi et al.   BRITISH JOURNAL OF CANCER

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

(2011) P. Timpson et al.   CANCER RESEARCH

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration

(2011) W.Andrew Yeudall et al.   CARCINOGENESIS

Interaction of tumor cells with the microenvironment

(2011) Hendrik Ungefroren et al.   Cell Communication and Signaling

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53 Disrupts MCF-10A Cell Polarity in Three-dimensional Culture via Epithelial-to-mesenchymal Transitions

(2011) Yanhong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms by Which the Extracellular Matrix and Integrin Signaling Act to Regulate the Switch Between Tumor Suppression and Tumor Promotion

(2011) Patricia J. Keely   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Loss of Rho GDIα and Resistance to Tamoxifen via Effects on Estrogen Receptor α

(2011) Ines Barone et al.   JNCI-Journal of the National Cancer Institute

Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin

(2011) Juhui Qiu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F

(2011) S. Jurmeister et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

miR-34 miRNAs provide a barrier for somatic cell reprogramming

(2011) Yong Jin Choi et al.   NATURE CELL BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

(2011) J E Noll et al.   ONCOGENE

Cell Migration and Invasion Assays as Tools for Drug Discovery

(2011) Keren I. Hulkower et al.   Pharmaceutics

Mutant p53 R248Q but not R248W enhances in vitro invasiveness of human lung cancer NCI-H1299 cells

(2010) Kazuhito Yoshikawa et al.   BIOMEDICAL RESEARCH-TOKYO

A MicroRNA Targeting Dicer for Metastasis Control

(2010) Graziano Martello et al.   CELL

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy

(2010) Gianluca Bossi et al.   CELL CYCLE

Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells

(2010) I Kogan-Sakin et al.   CELL DEATH AND DIFFERENTIATION

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

(2010) Daniel R Croft et al.   CELL RESEARCH

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma

(2010) Liang Zhao et al.   FEBS Journal

Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

(2010) Rachel Sarig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and Invasion

(2010) U. K. Mukhopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells

(2010) Diarmuid M. Moran et al.   MOLECULAR CANCER THERAPEUTICS

Stage-specific sensitivity to p53 restoration during lung cancer progression

(2010) David M. Feldser et al.   NATURE

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Alternative splicing of p53 and p73: the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer

(2010) G Hofstetter et al.   ONCOGENE

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

Negative Regulation of  4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression

(2009) G. Bon et al.   CANCER RESEARCH

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

(2009) Viola Vogel et al.   CURRENT OPINION IN CELL BIOLOGY

Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions

(2009) C. Albiges-Rizo et al.   JOURNAL OF CELL SCIENCE

p53 Suppresses Src-Induced Podosome and Rosette Formation and Cellular Invasiveness through the Upregulation of Caldesmon

(2009) U. K. Mukhopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway

(2009) Peixin Dong et al.   Molecular Cancer

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway

(2009) C Tanikawa et al.   ONCOGENE

A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

(2009) K.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Involvement of Members of the Cadherin Superfamily in Cancer

(2009) G. Berx et al.   Cold Spring Harbor Perspectives in Biology

Activated p53 induces NF-κB DNA binding but suppresses its transcriptional activation

(2008) Keiko Kawauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

The Mammary Progenitor Marker CD61/ 3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis

(2008) F. Vaillant et al.   CANCER RESEARCH

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Migratory neighbors and distant invaders: tumor-associated niche cells

(2008) J. Wels et al.   GENES & DEVELOPMENT

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Cell motility through plasma membrane blebbing

(2008) Oliver T. Fackler et al.   JOURNAL OF CELL BIOLOGY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Twist and p53 reciprocally regulate target genes via direct interaction

(2008) M Shiota et al.   ONCOGENE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One