Chromatin and oxygen sensing in the context of JmjC histone demethylases

Chromatin dynamics: Interplay between remodeling enzymes and histone modifications

(2014) Sarah G. Swygert et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1

(2014) Rachel Schiller et al.   ChemMedChem

Histone variants: dynamic punctuation in transcription

(2014) C. M. Weber et al.   GENES & DEVELOPMENT

HIF-1-Dependent Induction of Jumonji Domain-Containing Protein (JMJD) 3 under Hypoxic Conditions

(2014) Ho-Youl Lee et al.   MOLECULES AND CELLS

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Pan-genomic binding of hypoxia-inducible transcription factors

(2013) Johannes Schödel et al.   BIOLOGICAL CHEMISTRY

Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis

(2013) Y.-C. Teng et al.   CANCER RESEARCH

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

(2013) Geeta J. Narlikar et al.   CELL

The NuRD architecture

(2013) Hillary F. Allen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner

(2013) O. Copur et al.   DEVELOPMENT

Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen

(2013) Joyce Sayegh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling

(2013) Klaus W. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities

(2013) Dante Rotili et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel insights into histone modifiers in adipogenesis

(2013) Yosuke Okuno et al.   Adipocyte

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

(2012) Esther C. Y. Woon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Histone demethylase JMJD5 is essential for embryonic development

(2012) Sangphil Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase

(2012) Elena M. Sánchez-Fernández et al.   BIOCHEMICAL JOURNAL

Making sense of transcribing chromatin

(2012) Tom Owen-Hughes et al.   CURRENT OPINION IN CELL BIOLOGY

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

(2012) WeiShen Aik et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Epigenetic Regulation of Adipogenesis by PHF2 Histone Demethylase

(2012) Y. Okuno et al.   DIABETES

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

(2012) Nathan R. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone H3 Lysine 36 Methylation Targets the Isw1b Remodeling Complex to Chromatin

(2012) V. E. Maltby et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27

(2012) F. Tie et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization

(2012) Chibawanye I. Ene et al.   PLoS One

Microarray Comparative Genomic Hybridization Detection of Copy Number Changes in Desmoplastic Melanoma and Malignant Peripheral Nerve Sheath Tumor

(2011) Jennifer G Pryor et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

The Testis-Enriched Histone Demethylase, KDM4D, Regulates Methylation of Histone H3 Lysine 9 During Spermatogenesis in the Mouse but Is Dispensable for Fertility1

(2011) Naoki Iwamori et al.   BIOLOGY OF REPRODUCTION

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

(2011) J. He et al.   BLOOD

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state

(2011) David Frescas et al.   CELL CYCLE

Chromatin as an oxygen sensor and active player in the hypoxia response

(2011) Andrew Melvin et al.   CELLULAR SIGNALLING

UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program

(2011) Seunghee Lee et al.   DEVELOPMENTAL CELL

The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice

(2011) Qing-Jun Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly

(2011) Tsuyoshi Fukuda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH

(2011) Andrew Melvin et al.   MOLECULAR BIOLOGY OF THE CELL

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer

(2011) Eric C. Kauffman et al.   MOLECULAR CARCINOGENESIS

FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway

(2011) Filippos Kottakis et al.   MOLECULAR CELL

The von Hippel–Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C

(2011) X Niu et al.   ONCOGENE

Hypoxia-induced methylation of a pontin chromatin remodeling factor

(2011) J. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

(2011) L. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase

(2010) X. Zhou et al.   CANCER RESEARCH

Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity

(2010) Michaela Tausendschön et al.   CYTOKINE

Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development

(2010) Brenda J. Curtis et al.   DEVELOPMENTAL BIOLOGY

Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8

(2010) Joel A. Yates et al.   FEBS LETTERS

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

(2010) Y.-i. Tsukada et al.   GENES & DEVELOPMENT

Phenotypic annotation of the mouse X chromosome

(2010) B. J. Cox et al.   GENOME RESEARCH

The Role of Histone Modifications and Variants in Regulating Gene Expression in Breast Cancer

(2010) Mathieu Dalvai et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

(2010) Shinya Hayami et al.   Molecular Cancer

A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation

(2010) Daniela Kleine-Kohlbrecher et al.   MOLECULAR CELL

Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

(2010) Jason S. Lee et al.   MOLECULAR CELL

Regulation of Androgen-Responsive Transcription by the Chromatin Remodeling Factor CHD8

(2010) Tushar Menon et al.   MOLECULAR ENDOCRINOLOGY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications

(2009) Catherine A. Musselman et al.   BIOCHEMICAL JOURNAL

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

(2009) Francesca De Santa et al.   EMBO JOURNAL

The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila

(2009) Meridith T. Lorbeck et al.   GENE

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

(2009) K. Agger et al.   GENES & DEVELOPMENT

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice

(2009) Takeshi Inagaki et al.   GENES TO CELLS

Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns

(2009) M. P. Schnetz et al.   GENOME RESEARCH

Quantitative analysis of chromatin compaction in living cells using FLIM–FRET

(2009) David Llères et al.   JOURNAL OF CELL BIOLOGY

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

(2009) Keisuke Tateishi et al.   NATURE

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

(2009) G Liu et al.   ONCOGENE

Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing theInk4a/Arflocus

(2009) Alexandros Tzatsos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

(2008) Sven Wellmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Mucosa-Associated Lymphoid Tissue Lymphoma: Novel Translocations Including Rearrangements of ODZ2, JMJD2C, and CNN3

(2008) U. Vinatzer et al.   CLINICAL CANCER RESEARCH

dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

(2008) A. Lagarou et al.   GENES & DEVELOPMENT

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SWI/SNF Regulates the Cellular Response to Hypoxia

(2008) Niall S. Kenneth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

(2008) Amber Buescher Johnson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process

(2008) R. Pfau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA