Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases

Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria

(2011) Heeyong Yoon et al.   BIOCHEMICAL JOURNAL

Hypoxia-Inducible Factor-1α Contributes to Brain Edema after Stroke by Regulating Aquaporins and Glycerol Distribution in Brain

(2011) Tetsuhiro Higashida et al.   CURRENT NEUROVASCULAR RESEARCH

The metabolism and toxicity of hemin in astrocytes

(2011) Theresa N. Dang et al.   GLIA

Ceruloplasmin Deficiency Reduces Levels of Iron and BDNF in the Cortex and Striatum of Young Mice and Increases Their Vulnerability to Stroke

(2011) Sarah J. Texel et al.   PLoS One

Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage

(2010) Shiu-Hwa Yeh et al.   BRAIN PATHOLOGY

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

(2010) Na Zhang et al.   Cell Metabolism

Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation

(2010) Natalya A. Smirnova et al.   CHEMISTRY & BIOLOGY

Neuroprotection by Dimethyloxalylglycine following Permanent and Transient Focal Cerebral Ischemia in Rats

(2010) Simon Nagel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dipeptidyl-Quinolone Derivatives Inhibit Hypoxia Inducible Factor-1α Prolyl Hydroxylases-1, -2, and -3 with Altered Selectivity

(2010) Justin K. Murray et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury

(2010) Tetsuhiro Higashida et al.   JOURNAL OF NEUROSURGERY

Deferoxamine Treatment for Intracerebral Hemorrhage in Aged Rats

(2010) Masanobu Okauchi et al.   STROKE

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

(2009) Qing Zhang et al.   CANCER CELL

Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

(2009) A. Siddiq et al.   JOURNAL OF NEUROSCIENCE

Prolyl Hydroxylase Inhibitors Depend on Extracellular Glucose and Hypoxia-Inducible Factor (HIF)-2  to Inhibit Cell Death Caused by Nerve Growth Factor (NGF) Deprivation: Evidence that HIF-2  Has a Role in NGF-Promoted Survival of Sympathetic Neurons

(2009) D. J. Lomb et al.   MOLECULAR PHARMACOLOGY

Generating specificity and diversity in the transcriptional response to hypoxia

(2009) Urban Lendahl et al.   NATURE REVIEWS GENETICS

Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke

(2009) Stephen R. Robinson et al.   REDOX REPORT

Measurement of Phosphorylated Extracellular Signal-Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology

(2009) D. L. Hay   Science Signaling

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

(2008) Jennifer H. Dao et al.   ANALYTICAL BIOCHEMISTRY

The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress

(2008) O. Mikhaylova et al.   MOLECULAR AND CELLULAR BIOLOGY

Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation

(2008) Krista Rantanen et al.   MOLECULAR BIOLOGY OF THE CELL