The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

The hypoxic response and aging

(2011) Matt Kaeberlein et al.   CELL CYCLE

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity

(2010) Tao Tan et al.   EXPERIMENTAL PHYSIOLOGY

Inter-connection between mitochondria and HIFs

(2010) Kathryn V. Tormos et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Some highlights of research on aging with invertebrates, 2009

(2009) Linda Partridge   AGING CELL

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

Contribution of hypoxia to Alzheimer’s disease: is HIF-1α a mediator of neurodegeneration?

(2009) O. O. Ogunshola et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Two Distinct Roles for EGL-9 in the Regulation of HIF-1-Mediated Gene Expression in Caenorhabditis elegans

(2009) Z. Shao et al.   GENETICS

The von Hippel Lindau Tumor Suppressor Limits Longevity

(2009) R.-U. Muller et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hydrogen Sulfide Increases Hypoxia-inducible Factor-1 Activity Independently of von Hippel–Lindau Tumor Suppressor-1 in C. elegans

(2009) Mark W. Budde et al.   MOLECULAR BIOLOGY OF THE CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

(2009) William Mair et al.   PLoS One

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Divergent Mechanisms Controlling Hypoxic Sensitivity and Lifespan by the DAF-2/Insulin/IGF-Receptor Pathway

(2009) Meghann E. Mabon et al.   PLoS One

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans

(2009) Audrey Bellier et al.   PLoS Pathogens

Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression

(2008) Susanne Rohrbach et al.   BIOGERONTOLOGY

Systematic Identification of Gene Activities Promoting Hypoxic Death

(2008) M. E. Mabon et al.   GENETICS

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

HIF-1 regulation: not so easy come, easy go

(2008) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES