NADPH Oxidase Biology and the Regulation of Tyrosine Kinase Receptor Signaling and Cancer Drug Cytotoxicity

Adenosine triphosphate regulates NADPH oxidase activity leading to hydrogen peroxide production and COX-2/PGE2 expression in A549 cells

(2012) Chih-Chung Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Balancing Reactive Oxygen Species in the Epigenome: NADPH Oxidases as Target and Perpetrator

(2012) Patti Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Eat-Me: Autophagy, Phagocytosis, and Reactive Oxygen Species Signaling

(2012) Philip J. Vernon et al.   ANTIOXIDANTS & REDOX SIGNALING

The NADPH Oxidase Family and its Inhibitors

(2012) Paulina Kleniewska et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway

(2012) J. Honeychurch et al.   BLOOD

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting tumor neovasculature in non-small-cell lung cancer

(2012) Athanasios G. Pallis et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Anti-metastatic Treatment in Colorectal Cancer: Targeting Signaling Pathways

(2012) Clara Lemos et al.   CURRENT PHARMACEUTICAL DESIGN

A targeted enzyme approach to sensitization of tyrosine kinase inhibitor-resistant breast cancer cells

(2012) Courtney R. Giordano et al.   EXPERIMENTAL CELL RESEARCH

The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA

(2012) Candice Hoste et al.   EXPERIMENTAL CELL RESEARCH

Cell Signaling through Protein Kinase C Oxidation and Activation

(2012) Daniela Cosentino-Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of pancreatic cancer growth by superoxide

(2012) Juan Du et al.   MOLECULAR CARCINOGENESIS

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation

(2012) B K Nayak et al.   ONCOGENE

NADPH Oxidase 4 Mediates Insulin-Stimulated HIF-1α and VEGF Expression, and Angiogenesis In Vitro

(2012) Dan Meng et al.   PLoS One

Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

(2012) Maura Calvani et al.   PLoS One

Redox control of cell proliferation

(2012) Joyce Chiu et al.   TRENDS IN CELL BIOLOGY

Targeting NADPH oxidases in vascular pharmacology

(2012) Agata Schramm et al.   VASCULAR PHARMACOLOGY

Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain

(2011) Jennifer L. Meitzler et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells

(2011) Mahandranauth A. Chetram et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance

(2011) Brian M. Barth et al.   CANCER BIOLOGY & THERAPY

Erlotinib-Mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4

(2011) K. P. Orcutt et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells

(2011) Fabio Cattaneo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells

(2011) Wei-Chien Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi Fujii Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme

(2011) Masato Katsuyama et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage

(2011) Daniel R. Premkumar et al.   MOLECULAR CARCINOGENESIS

Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation

(2011) Terry W. Moody et al.   PEPTIDES

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

TACE/ADAM-17 Phosphorylation by PKC-Epsilon Mediates Premalignant Changes in Tobacco Smoke-Exposed Lung Cells

(2011) Hassan Lemjabbar-Alaoui et al.   PLoS One

Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

(2011) Luca A. Petruccelli et al.   PLoS One

NADPH Oxidase Subunit 4-Mediated Reactive Oxygen Species Contribute to Cycling Hypoxia-Promoted Tumor Progression in Glioblastoma Multiforme

(2011) Chia-Hung Hsieh et al.   PLoS One

Redox Regulation of Protein Kinases as a Modulator of Vascular Function

(2010) Greg A. Knock et al.   ANTIOXIDANTS & REDOX SIGNALING

Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound  -phenylethyl isothiocyanate

(2010) Y. Hu et al.   BLOOD

Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer

(2010) J Du et al.   CANCER GENE THERAPY

A NADPH Oxidase–Dependent Redox Signaling Pathway Mediates the Selective Radiosensitization Effect of Parthenolide in Prostate Cancer Cells

(2010) Yulan Sun et al.   CANCER RESEARCH

NADPH Oxidase NOX1 Controls Autocrine Growth of Liver Tumor Cells through Up-regulation of the Epidermal Growth Factor Receptor Pathway

(2010) Patricia Sancho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGF receptor activation by GPCRs: An universal pathway reveals different versions

(2010) Claus Liebmann   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells

(2010) Jeewon Kim et al.   PROSTATE

Redox regulation of Nox proteins

(2010) Srikanth Pendyala et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Reactive Oxygen Species Mediate Mitogenic Growth Factor Signaling Pathways in Human Leiomyoma Smooth Muscle Cells1

(2009) Fernando S. Mesquita et al.   BIOLOGY OF REPRODUCTION

Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines

(2009) Laetitia Dahan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF- -Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4

(2009) L. Caja et al.   CANCER RESEARCH

Reactive oxygen species-dependent signaling regulates cancer

(2009) Frank Weinberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy

(2009) E. Martinelli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Modulation of Trypanosoma rangeli ecto-phosphatase activity by hydrogen peroxide

(2009) Daniela Cosentino-Gomes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive Oxygen Generated by NADPH Oxidase 1 (Nox1) Contributes to Cell Invasion by Regulating Matrix Metalloprotease-9 Production and Cell Migration

(2009) Masahiro Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of p22phoxon Threonine 147 Enhances NADPH Oxidase Activity by Promoting p47phoxBinding

(2009) Eric M. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditis elegansand Human Dual Oxidase 1 (DUOX1) “Peroxidase” Domains

(2009) Jennifer L. Meitzler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Dual Oxidases Duox1 and Duox2

(2009) Sabrina Rigutto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine-tuning of GPCR activity by receptor-interacting proteins

(2009) Stefanie L. Ritter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase

(2009) J P Lu et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Activation of NADPH oxidase 1 in tumour colon epithelial cells

(2008) Yukio Nisimoto et al.   BIOCHEMICAL JOURNAL

Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells

(2008) Conrad Ortiz et al.   BIOCHEMICAL PHARMACOLOGY

Reactive oxygen species: Destroyers or messengers?

(2008) Grzegorz Bartosz   BIOCHEMICAL PHARMACOLOGY

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

(2008) Patricia Sancho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox

(2008) Houssam Raad et al.   FASEB JOURNAL

Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation

(2008) Stanislas Morand et al.   FASEB JOURNAL

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

(2008) S DIKALOV et al.   FREE RADICAL BIOLOGY AND MEDICINE

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

(2008) Irene Carmona-Cuenca et al.   JOURNAL OF HEPATOLOGY

Phosphatidylinositol (4,5)-bisphosphate Modulates Nox5 Localization via an N-Terminal Polybasic Region

(2008) Tsukasa Kawahara et al.   MOLECULAR BIOLOGY OF THE CELL

The Involvement of the Tyrosine Kinase c-Src in the Regulation of Reactive Oxygen Species Generation Mediated by NADPH Oxidase-1

(2008) Davide Gianni et al.   MOLECULAR BIOLOGY OF THE CELL

Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

(2008) Y Adachi et al.   ONCOGENE

NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

(2008) D Komatsu et al.   ONCOGENE

Role of Nox2 in elimination of microorganisms

(2008) Balázs Rada et al.   Seminars in Immunopathology

Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

(2008) Kazuhito Rokutan et al.   Seminars in Immunopathology