Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS)

(2012) Tiziana Bachetti et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

(2012) Y.-H. Liao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

On-demand anakinra treatment is effective in mevalonate kinase deficiency

(2011) E. J. Bodar et al.   ANNALS OF THE RHEUMATIC DISEASES

TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential

(2011) Im Sun Woo et al.   CANCER LETTERS

Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy

(2011) Ligia C. Gomes et al.   CELL CYCLE

Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases

(2011) Sinisa Savic et al.   CURRENT OPINION IN RHEUMATOLOGY

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Hydrophobic statins induce autophagy and cell death in human rhabdomyosarcoma cells by depleting geranylgeranyl diphosphate

(2011) Makoto Araki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response

(2011) Johanneke Kleinnijenhuis et al.   IMMUNOLOGY

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies

(2010) P.-M. Yang et al.   CANCER RESEARCH

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency

(2010) L. Henneman et al.   JOURNAL OF INHERITED METABOLIC DISEASE

A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells

(2010) K. M. Sane et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1  secretion

(2010) S. Tassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells

(2010) Ankur Parikh et al.   PROSTATE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

DAMPs and inflammatory processes: the role of redox in the different outcomes

(2009) Sonia Carta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMG-CoA reductase inhibition induces IL-1  release through Rac1/PI3K/PKB-dependent caspase-1 activation

(2008) L. M. Kuijk et al.   BLOOD

Statin synergizes with LPS to induce IL-1β release by THP-1 cells through activation of caspase-1

(2008) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE