Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment

Understanding redundancy and resilience

(2022) Philip Hunter   EMBO REPORTS

Acto-myosin network geometry defines centrosome position

(2021) Ana Joaquina Jimenez et al.   CURRENT BIOLOGY

The effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling

(2021) Alexander J. Gates et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-Dependent Interactions between Talin and Full-Length Vinculin

(2021) Yinan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

(2021) Ion Andreu et al.   Nature Communications

Collective durotaxis along a self-generated stiffness gradient in vivo

(2021) Adam Shellard et al.   NATURE

Microtubules tune mechanosensitive cell responses

(2021) Shailaja Seetharaman et al.   NATURE MATERIALS

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells

(2020) Yong Hou et al.   Small

Mechanomics Approaches to Understand Cell Behavior in Context of Tissue Neogenesis, During Prenatal Development and Postnatal Healing

(2020) Vina D. L. Putra et al.   Frontiers in Cell and Developmental Biology

The Balance between Actomyosin Contractility and Microtubule Polymerization Regulates Hierarchical Protrusions That Govern Efficient Fibroblast–Collagen Interactions

(2020) Delaram Shakiba et al.   ACS Nano

The Mechanical Role of Microtubules in Tissue Remodeling

(2020) Maja Matis   BIOESSAYS

Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels

(2020) Nuria Barber-Pérez et al.   JOURNAL OF CELL SCIENCE

Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch

(2020) Matthew Walker et al.   Scientific Reports

Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

(2020) Charlotte F Kelley et al.   eLife

Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation

(2020) Stefan Biedzinski et al.   EMBO JOURNAL

Advanced Design and Manufacture of Mechanoactive Materials Inspired by Skin, Bones, and Skin-on-Bones

(2020) Melissa Louise Knothe Tate   Frontiers in Bioengineering and Biotechnology

Biased localization of actin binding proteins by actin filament conformation

(2020) Andrew R. Harris et al.   Nature Communications

Anisotropic Nanoscale Presentation of Cell Adhesion Ligand Enhances the Recruitment of Diverse Integrins in Adhesion Structures and Mechanosensing-Dependent Differentiation of Stem Cells

(2019) Siu Hong Dexter Wong et al.   ADVANCED FUNCTIONAL MATERIALS

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila

(2019) Mélanie Gracia et al.   Nature Communications

Dynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns

(2019) Nick R. M. Beijer et al.   Scientific Reports

Fluorescence Imaging of Actin Turnover Parses Early Stem Cell Lineage Divergence and Senescence

(2019) Prakhar Mishra et al.   Scientific Reports

High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

(2019) Jiliang Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vimentin protects cells against nuclear rupture and DNA damage during migration

(2019) Alison E. Patteson et al.   JOURNAL OF CELL BIOLOGY

Membrane curvature underlies actin reorganization in response to nanoscale surface topography

(2019) Hsin-Ya Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relief of talin autoinhibition triggers a force-independent association with vinculin

(2019) Paul Atherton et al.   JOURNAL OF CELL BIOLOGY

OUP accepted manuscript

(2018)   BIOINFORMATICS

The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation viaα-TAT1gene expression

(2018) Jaime Fernández-Barrera et al.   JOURNAL OF CELL BIOLOGY

Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing

(2018) Asako Shindo et al.   JOURNAL OF CELL SCIENCE

Dynamic force patterns promote collective cell movements during embryonic wound repair

(2018) Teresa Zulueta-Coarasa et al.   Nature Physics

Role of the supracellular actomyosin cable during epithelial wound healing

(2018) Yanjun Yang et al.   Soft Matter

Actin depolymerization enhances adipogenic differentiation in human stromal stem cells

(2018) Li Chen et al.   Stem Cell Research

Human mesenchymal stem cells lose their functional properties after paclitaxel treatment

(2018) Franziska Münz et al.   Scientific Reports

Cross-talk between microtubules and the linker of nucleoskeleton complex plays a critical role in the adipogenesis of human adipose-derived stem cells

(2018) Yiting Yang et al.   Stem Cell Research & Therapy

Osteoblast response to disordered nanotopography

(2018) Christopher Allan et al.   Journal of Tissue Engineering

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

(2018) Elias H. Barriga et al.   NATURE

AIP1 and cofilin ensure a resistance to tissue tension and promote directional cell rearrangement

(2018) Keisuke Ikawa et al.   Nature Communications

Conformational states during vinculin unlocking differentially regulate focal adhesion properties

(2018) Dror S. Chorev et al.   Scientific Reports

Pressure-induced mesenchymal stem cell osteogenesis is dependent on intermediate filament remodeling

(2018) Elena Stavenschi et al.   FASEB JOURNAL

Tension (re)builds: Biophysical mechanisms of embryonic wound repair

(2017) Teresa Zulueta-Coarasa et al.   MECHANISMS OF DEVELOPMENT

Effects of substrate stiffness and actomyosin contractility on coupling between force transmission and vinculin–paxillin recruitment at single focal adhesions

(2017) Dennis W. Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

Actin and microtubule networks contribute differently to cell response for small and large strains

(2017) H Kubitschke et al.   NEW JOURNAL OF PHYSICS

Vimentin fibers orient traction stress

(2017) Nancy Costigliola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranuclear Actin Structure Modulates Mesenchymal Stem Cell Differentiation

(2017) Buer Sen et al.   STEM CELLS

Identifying the dynamics of actin and tubulin polymerization in iPSCs and in iPSC-derived neurons

(2017) Valentina Magliocca et al.   Oncotarget

Rock signaling control PPARγ expression and actin polymerization during adipogenesis

(2017) Yuntao Ji et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Establishing the Basis for Mechanobiology-Based Physical Therapy Protocols to Potentiate Cellular Healing and Tissue Regeneration

(2017) Joanna L. Ng et al.   Frontiers in Physiology

Cell stiffness determined by atomic force microscopy and its correlation with cell motility

(2016) Qing Luo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An Integrated Stochastic Model of Matrix-Stiffness-Dependent Filopodial Dynamics

(2016) Bo Cheng et al.   BIOPHYSICAL JOURNAL

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Shear stress and circumferential stretch by pulsatile flow direct vascular endothelial lineage commitment of mesenchymal stem cells in engineered blood vessels

(2016) Dong Hwa Kim et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

The molecular clutch model for mechanotransduction evolves

(2016) Vinay Swaminathan et al.   NATURE CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Microtubule-associated protein 1b is required for shaping the neural tube

(2016) Pradeepa Jayachandran et al.   Neural Development

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Cytoskeletal Configuration Modulates Mechanically Induced Changes in Mesenchymal Stem Cell Osteogenesis, Morphology, and Stiffness

(2016) Suphannee Pongkitwitoon et al.   Scientific Reports

Nanostructured scaffold as a determinant of stem cell fate

(2016) Lekshmi Krishna et al.   Stem Cell Research & Therapy

Live Tissue Imaging to Elucidate Mechanical Modulation of Stem Cell Niche Quiescence

(2016) Nicole Y.C. Yu et al.   Stem Cells Translational Medicine

Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration

(2016) Zhuo Gan et al.   Cell Systems

Cytoskeletal Expression and Remodeling in Pluripotent Stem Cells

(2016) Liana C. Boraas et al.   PLoS One

Geometric guidance of integrin mediated traction stress during stem cell differentiation

(2015) Junmin Lee et al.   BIOMATERIALS

Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo

(2015) Chaminda R. Samarage et al.   DEVELOPMENTAL CELL

Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function

(2015) Jason Lowery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and Turnover of Short Actin Filaments by the Formin INF2 and Profilin

(2015) Pinar S. Gurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair

(2015) Miranda V. Hunter et al.   JOURNAL OF CELL BIOLOGY

Paclitaxel impairs adipose stem cell proliferation and differentiation

(2015) Rachel L. Choron et al.   JOURNAL OF SURGICAL RESEARCH

Cytoskeleton remodelling of confluent epithelial cells cultured on porous substrates

(2015) J. Rother et al.   Journal of the Royal Society Interface

Modulation of bone’s sensitivity to low-intensity vibrations by acceleration magnitude, vibration duration, and number of bouts

(2015) S. Judex et al.   OSTEOPOROSIS INTERNATIONAL

Human Mesenchymal Stem Cells Are Resistant to Paclitaxel by Adopting a Non-Proliferative Fibroblastic State

(2015) Dale B. Bosco et al.   PLoS One

Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells

(2015) Li Chen et al.   Stem Cell Research

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

(2015) Mukund Gupta et al.   Nature Communications

Filopodia-based Wnt transport during vertebrate tissue patterning

(2015) Eliana Stanganello et al.   Nature Communications

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Buckling of Microtubules on a 2D Elastic Medium

(2015) Arif Md. Rashedul Kabir et al.   Scientific Reports

Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling

(2015) Poulomi Ray et al.   PLoS One

Actin flow and talin dynamics govern rigidity sensing in actin-integrin linkage through talin extension

(2014) H. Hirata et al.   Journal of the Royal Society Interface

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Shear Stress Induced by an Interstitial Level of Slow Flow Increases the Osteogenic Differentiation of Mesenchymal Stem Cells through TAZ Activation

(2014) Kyung Min Kim et al.   PLoS One

A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton

(2014) Matthew R. Stachowiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-specific mechanical and geometrical control of cell viability and actin cytoskeleton alignment

(2014) Dong Wang et al.   Scientific Reports

Mechanistic, Mathematical Model to Predict the Dynamics of Tissue Genesis in Bone Defects via Mechanical Feedback and Mediation of Biochemical Factors

(2014) Shannon R. Moore et al.   PLoS Computational Biology

Mechanical modulation of nascent stem cell lineage commitment in tissue engineering scaffolds

(2013) Min Jae Song et al.   BIOMATERIALS

How cells sense extracellular matrix stiffness: a material's perspective

(2013) Britta Trappmann et al.   CURRENT OPINION IN BIOTECHNOLOGY

In vivomultimodal microscopy for detecting bone-marrow-derived cell contribution to skin regeneration

(2013) Benedikt W. Graf et al.   Journal of Biophotonics

The tension mounts: Stress fibers as force-generating mechanotransducers

(2013) Keith Burridge et al.   JOURNAL OF CELL BIOLOGY

Modulating the Actin Cytoskeleton Affects Mechanically Induced Signal Transduction and Differentiation in Mesenchymal Stem Cells

(2013) Petra Müller et al.   PLoS One

Tension modulates actin filament polymerization mediated by formin and profilin

(2013) N. Courtemanche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin

(2012) Wulin Yang et al.   BIOCHEMICAL JOURNAL

Solid-supported lipid bilayers to drive stem cell fate and tissue architecture using periosteum derived progenitor cells

(2012) Sarah F. Evans et al.   BIOMATERIALS

Shear stress during early embryonic stem cell differentiation promotes hematopoietic and endothelial phenotypes

(2012) Russell P. Wolfe et al.   BIOTECHNOLOGY AND BIOENGINEERING

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Mapping the Mechanome of Live Stem Cells Using a Novel Method to Measure Local Strain Fields In Situ at the Fluid-Cell Interface

(2012) Min Jae Song et al.   PLoS One

Physically-Induced Cytoskeleton Remodeling of Cells in Three-Dimensional Culture

(2012) Sheng-Lin Lee et al.   PLoS One

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

(2012) E. Anon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Cytoskeletal and Focal Adhesion Influences on Mesenchymal Stem Cell Shape, Mechanical Properties, and Differentiation Down Osteogenic, Adipogenic, and Chondrogenic Pathways

(2012) Pattie S. Mathieu et al.   TISSUE ENGINEERING PART B-REVIEWS

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

(2012) Dong-Hwee Kim et al.   Scientific Reports

Apoptotic regulation of epithelial cellular extrusion

(2011) Daniel Andrade et al.   APOPTOSIS

Spacing of Integrin Ligands Influences Signal Transduction in Endothelial Cells

(2011) Guillaume Le Saux et al.   BIOPHYSICAL JOURNAL

Heparan sulfate proteoglycan mediates shear stress-induced endothelial gene expression in mouse embryonic stem cell-derived endothelial cells

(2011) Maria Nikmanesh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces

(2011) Ravi A. Desai et al.   Integrative Biology

Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

(2011) Kimihide Hayakawa et al.   JOURNAL OF CELL BIOLOGY

Dynamic actin remodeling during epithelial–mesenchymal transition depends on increased moesin expression

(2011) Jennifer Haynes et al.   MOLECULAR BIOLOGY OF THE CELL

Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity

(2011) Michael T Yang et al.   Nature Protocols

Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation

(2011) Daisuke Sakai et al.   PLoS One

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Crawling Cells Can Close Wounds without Purse Strings or Signaling

(2011) Pilhwa Lee et al.   PLoS Computational Biology

Effect of Fluid Shear Stress on Cardiomyogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells

(2010) Yan Huang et al.   ARCHIVES OF MEDICAL RESEARCH

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

The epigenetic mechanism of mechanically induced osteogenic differentiation

(2010) Emily J. Arnsdorf et al.   JOURNAL OF BIOMECHANICS

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Differentiation of Adipose-Derived Stem Cells from Elderly Patients with Cardiovascular Disease

(2010) Ping Zhang et al.   STEM CELLS AND DEVELOPMENT

Response of mesenchymal stem cells to shear stress in tissue-engineered vascular grafts

(2009) Jian-de Dong et al.   ACTA PHARMACOLOGICA SINICA

Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations

(2009) Ke Bai et al.   JOURNAL OF BIOMECHANICS

Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion

(2009) Jinghuan Huang et al.   NANO LETTERS

Force amplification response of actin filaments under confined compression

(2009) G. W. Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoskeleton-based forecasting of stem cell lineage fates

(2009) M. D. Treiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrostatic Pressure Enhances Chondrogenic Differentiation of Human Bone Marrow Stromal Cells in Osteochondrogenic Medium

(2008) Diane R. Wagner et al.   ANNALS OF BIOMEDICAL ENGINEERING

Dynamics of Cellular Focal Adhesions on Deformable Substrates: Consequences for Cell Force Microscopy

(2008) Alice Nicolas et al.   BIOPHYSICAL JOURNAL

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

(2008) Elisabetta Ada Cavalcanti‐Adam et al.   HFSP Journal

Mechanical modulation of osteochondroprogenitor cell fate

(2008) Melissa L. Knothe Tate et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of Microtubule Assembly in Osteoblasts Stimulates Bone Morphogenetic Protein 2 Expression and Bone Formation through Transcription Factor Gli2

(2008) M. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

Pulsed contractions of an actin–myosin network drive apical constriction

(2008) Adam C. Martin et al.   NATURE

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures

(2008) Sami Alom Ruiz et al.   STEM CELLS

Modulation of Stem Cell Shape and Fate B: Mechanical Modulation of Cell Shape and Gene Expression

(2008) Sara H. McBride et al.   TISSUE ENGINEERING PART A

Modulation of Stem Cell Shape and Fate A: The Role of Density and Seeding Protocol on Nucleus Shape and Gene Expression

(2008) Sara H. McBride et al.   TISSUE ENGINEERING PART A

Effect of Intermittent Shear Stress on Mechanotransductive Signaling and Osteoblastic Differentiation of Bone Marrow Stromal Cells

(2008) Michelle R. Kreke et al.   TISSUE ENGINEERING PART A

Shear stress and vascular smooth muscle cells promote endothelial differentiation of endothelial progenitor cells via activation of Akt

(2007) Cao Ye et al.   CLINICAL BIOMECHANICS