Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

Haematopoietic stem cell activity and interactions with the niche

(2019) Sandra Pinho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical principles of nuclear shaping and positioning

(2018) Tanmay P. Lele et al.   JOURNAL OF CELL BIOLOGY

Comprehensive characterization of neutrophil genome topology

(2017) Yina Zhu et al.   GENES & DEVELOPMENT

Emerging roles of mechanical forces in chromatin regulation

(2017) Yekaterina A. Miroshnikova et al.   JOURNAL OF CELL SCIENCE

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Human haematopoietic stem cell lineage commitment is a continuous process

(2017) Lars Velten et al.   NATURE CELL BIOLOGY

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

(2017) Elisa Närvä et al.   Stem Cell Reports

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes

(2016) Justin S. Becker et al.   TRENDS IN GENETICS

Oocyte Polarization Is Coupled to the Chromosomal Bouquet, a Conserved Polarized Nuclear Configuration in Meiosis

(2016) Yaniv M. Elkouby et al.   PLOS BIOLOGY

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

(2016) Dounia Djeghloul et al.   Stem Cell Reports

The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity

(2016) Samer G. Alam et al.   Scientific Reports

The Neutrophil Nucleus and Its Role in Neutrophilic Function

(2015) Leonardo Olivieri Carvalho et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cytoskeletal Control of Nuclear Morphology and Chromatin Organization

(2015) Nisha M. Ramdas et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

(2015) Sarah M. Schreiner et al.   Nature Communications

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

(2015) Fernando Ugarte et al.   Stem Cell Reports

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells

(2014) M. H. Wilson et al.   DEVELOPMENT

Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells

(2014) Pierre Therizols et al.   SCIENCE

Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells

(2013) Jae-Won Shin et al.   Cell Stem Cell

Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates

(2013) Jae-Won Shin et al.   DIFFERENTIATION

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3

(2012) Bruno Cadot et al.   EMBO REPORTS

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Role of Actin Dependent Nuclear Deformation in Regulating Early Gene Expression

(2012) Soumya Gupta et al.   PLoS One

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

(2012) Marie Versaevel et al.   Nature Communications

A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase

(2011) Stéphanie Bolhy et al.   JOURNAL OF CELL BIOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

(2010) Daniël Splinter et al.   PLOS BIOLOGY

A HaemAtlas: characterizing gene expression in differentiated human blood cells

(2009) Nicholas A. Watkins et al.   BLOOD

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonlinear Osmotic Properties of the Cell Nucleus

(2008) John D. Finan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Dynamics of Chromatin Decondensation Reveals the Structural Integrity of a Mechanically Prestressed Nucleus

(2008) Aprotim Mazumder et al.   BIOPHYSICAL JOURNAL

A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules

(2008) Megan C. King et al.   CELL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL