The Vascular-Immune Hypothesis of Alzheimer’s Disease

FDA approves Alzheimer’s drug lecanemab amid safety concerns

(2023) Sara Reardon   NATURE

Association of small vessel disease with tau pathology

(2022) Alifiya Kapasi et al.   ACTA NEUROPATHOLOGICA

Chaperoning shape-shifting tau in disease

(2022) Bryan D. Ryder et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration

(2022) Kazuhisa Ishida et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease

(2022) Diane Bairamian et al.   Molecular Neurodegeneration

The dense-core plaques of Alzheimer’s disease are granulomas

(2022) Greg Lemke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroimmune contributions to Alzheimer’s disease: a focus on human data

(2022) Verena Haage et al.   MOLECULAR PSYCHIATRY

Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease

(2022) Humberto Mestre et al.   Nature Communications

What to Know About the Alzheimer Drug Aducanumab (Aduhelm)

(2022) Steven Woloshin et al.   JAMA Internal Medicine

Neuropathology of the Common Forms of Dementia

(2022) Rupal I. Mehta et al.   CLINICS IN GERIATRIC MEDICINE

Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s disease

(2022) Chao Gao et al.   Journal of Neuroinflammation

Synaptogenic effect of APP -Swedish mutation in familial Alzheimer’s disease

(2022) Bo Zhou et al.   Science Translational Medicine

Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment

(2022) Natalie Piehl et al.   CELL

Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma

(2022) Trishna Shah et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

(2022) Antoine Drieu et al.   NATURE

Extracellular vesicles in Alzheimer’s disease: from pathology to therapeutic approaches

(2022) AvneshS Thakor et al.   Neural Regeneration Research

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lecanemab in patients with early Alzheimer’s disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study

(2022) Eric McDade et al.   Alzheimers Research & Therapy

Promising candidates from drug clinical trials: Implications for clinical treatment of Alzheimer's disease in China

(2022) Yuxia Cao et al.   Frontiers in Neurology

Amyloid β-related angiitis of the central nervous system occurring after COVID-19 vaccination: A case report

(2022) Mayuki Kizawa et al.   World Journal of Clinical Cases

Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults

(2021) Daniel S. Albrecht et al.   BRAIN BEHAVIOR AND IMMUNITY

Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease

(2021) Rashi I. Mehta et al.   RADIOLOGY

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

The Notch Signaling Pathway Regulates Differentiation of NG2 Cells into Oligodendrocytes in Demyelinating Diseases

(2021) Chengcai Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

(2021) Sandro Da Mesquita et al.   NATURE

Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease

(2021) Huaqi Su et al.   Journal of Extracellular Vesicles

Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures

(2021) Sebastian Palmqvist et al.   NATURE MEDICINE

Controversy and Progress in Alzheimer’s Disease — FDA Approval of Aducanumab

(2021) Gil D. Rabinovici   NEW ENGLAND JOURNAL OF MEDICINE

SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

(2021) Christy Hung et al.   Cell Reports

Amyloid and Tau in Alzheimer’s Disease: Biomarkers or Molecular Targets for Therapy? Are We Shooting the Messenger?

(2021) Anand Kumar et al.   AMERICAN JOURNAL OF PSYCHIATRY

Amyloid beta acts synergistically as a pro-inflammatory cytokine

(2021) Thomas J. LaRocca et al.   NEUROBIOLOGY OF DISEASE

Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease

(2021) Trae Carroll et al.   Biology-Basel

Caveolin: A New Link Between Diabetes and AD

(2020) Andrei Surguchov   CELLULAR AND MOLECULAR NEUROBIOLOGY

Alzheimer’s Disease: From Amyloid to Autoimmune Hypothesis

(2020) Yuri I. Arshavsky   NEUROSCIENTIST

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain

(2020) Lindsay A. Welikovitch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Successful cognitive aging: What the oldest-old can teach us about resistance and resilience

(2020) Claudia H. Kawas et al.   NEUROLOGY

Neuropathologic and Cognitive Correlates of Enlarged Perivascular Spaces in a Community-Based Cohort of Older Adults

(2020) Carles Javierre-Petit et al.   STROKE

Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy

(2020) Giulia Castellani et al.   TRENDS IN IMMUNOLOGY

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

(2020) Amy F. T. Arnsten et al.   Alzheimers & Dementia

Cystatin C, cognition, and brain MRI findings in 90+-year-olds

(2020) Wei Ling Lau et al.   NEUROBIOLOGY OF AGING

Glymphatic failure as a final common pathway to dementia

(2020) Maiken Nedergaard et al.   SCIENCE

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Alzheimer’s Disease Neuropathological Comorbidities are Common in the Younger-Old

(2020) Thomas G. Beach et al.   JOURNAL OF ALZHEIMERS DISEASE

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment

(2019) Brati Das et al.   CNS DRUGS

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

The blood–brain barrier as an endocrine tissue

(2019) William A. Banks   Nature Reviews Endocrinology

Macrophages at CNS interfaces: ontogeny and function in health and disease

(2019) Katrin Kierdorf et al.   NATURE REVIEWS NEUROSCIENCE

Key inflammatory pathway activations in the MCI stage of Alzheimer’s disease

(2019) Jagan A. Pillai et al.   Annals of Clinical and Translational Neurology

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Person-specific contribution of neuropathologies to cognitive loss in old age

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

(2018) Frances K Wiseman et al.   BRAIN

Understanding the role of the perivascular space in cerebral small vessel disease

(2018) Rosalind Brown et al.   CARDIOVASCULAR RESEARCH

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies

(2018) Caixia Zhang et al.   Frontiers in Aging Neuroscience

Quantitative MRI of Perivascular Spaces at 3T for Early Diagnosis of Mild Cognitive Impairment

(2018) M. Niazi et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease

(2018) Ineke A. van Rossum et al.   JOURNAL OF ALZHEIMERS DISEASE

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?

(2018) Francesco Panza et al.   Immunotherapy

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

(2017) Minghuan Wang et al.   JOURNAL OF NEUROSCIENCE

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Does Alzheimer's Disease Result from Attempts at Repair or Protection After Transient Stress?

(2017) Garth Bissette   JOURNAL OF ALZHEIMERS DISEASE

Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons

(2016) A. Kapasi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia

(2016) Bryan D. James et al.   BRAIN

The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts

(2016) Zoe Arvanitakis et al.   BRAIN PATHOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The incidence of post-mortem neurodegenerative and cerebrovascular pathology in mixed dementia

(2016) Jacques De Reuck et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study

(2016) Zoe Arvanitakis et al.   LANCET NEUROLOGY

Incidence of Dementia over Three Decades in the Framingham Heart Study

(2016) Claudia L. Satizabal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heart and Brain Interconnection　– Clinical Implications of Changes in Brain Function During Heart Failure –

(2015) Min-Seok Kim et al.   CIRCULATION JOURNAL

Lymphatic vessels of the dura mater: a new discovery?

(2015) Fabio Bucchieri et al.   JOURNAL OF ANATOMY

Ischemic brain injury in cerebral amyloid angiopathy

(2015) Yael D Reijmer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

(2015) Patricia A. Boyle et al.   NEUROLOGY

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases

(2015) Bradley M. Coleman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Targeting Prodromal Alzheimer Disease With Avagacestat

(2015) Vladimir Coric et al.   JAMA Neurology

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

(2014) Deborah Doens et al.   Journal of Neuroinflammation

Prevalence of mixed pathologies in the aging brain

(2014) Jasmin Rahimi et al.   Alzheimers Research & Therapy

Much of late life cognitive decline is not due to common neurodegenerative pathologies

(2013) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

(2013) Jean-Philippe Michaud et al.   Cell Reports

Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress

(2013) Ilia A. Droujinine et al.   Frontiers in Cellular and Infection Microbiology

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Cognitive Deficits and Delayed Neuronal Loss in a Mouse Model of Multiple Microinfarcts

(2012) M. Wang et al.   JOURNAL OF NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Antimicrobial Properties of Amyloid Peptides

(2011) Bruce L. Kagan et al.   MOLECULAR PHARMACEUTICS

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias

(2008) L. Mosconi et al.   JOURNAL OF NUCLEAR MEDICINE