Extracellular vesicles in Alzheimer’s disease: from pathology to therapeutic approaches

A Versatile Platform for Generating Engineered Extracellular Vesicles with Defined Therapeutic Properties

(2021) Kevin Dooley et al.   MOLECULAR THERAPY

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models

(2021) Satoshi Muraoka et al.   JOURNAL OF PROTEOME RESEARCH

Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease

(2021) Lauren A. Apodaca et al.   Alzheimers Research & Therapy

Short-Term High-Intensity Treadmill Exercise Promotes Ceramide-Dependent Extracellular Vesicle Secretion in the Central Nervous System of Mice

(2021) Rui Zhang et al.   MEDICAL SCIENCE MONITOR

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

(2021) Kevin Clayton et al.   Molecular Neurodegeneration

Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease

(2021) Huaqi Su et al.   Journal of Extracellular Vesicles

Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons

(2021) Sonia Podvin et al.   ACS Omega

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

(2021) Su Chul Jang et al.   Communications Biology

Human adipose tissue-derived mesenchymal stem cells and their extracellular vesicles modulate lipopolysaccharide activated human microglia

(2021) Marta Garcia-Contreras et al.   Cell Death Discovery

Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway

(2021) Sha Sha et al.   Aging-US

Biomarkers of Alzheimer’s Disease and Cerebrovascular Lesions and Clinical Progression in Patients with Subjective Cognitive Decline: A Systematic Review

(2021) Morgan Scarth et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteome profiling of neuron-derived exosomes in Alzheimer's disease reveals hemoglobin as a potential biomarker

(2021) Burak Ibrahim Arioz et al.   NEUROSCIENCE LETTERS

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer’s Disease Pathology and Improve Cognitive Deficits

(2021) Yi-An Chen et al.   Biomedicines

Exosomes from human umbilical cord Mesenchymal stem cells attenuates stress-induced hippocampal dysfunctions

(2020) Yuhu Niu et al.   METABOLIC BRAIN DISEASE

In vivo evidence of exosome-mediated Aβ neurotoxicity

(2020) Ahmed Elsherbini et al.   Acta Neuropathologica Communications

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

(2020) Satoshi Muraoka et al.   Cells

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Optimising size exclusion chromatography for extracellular vesicle enrichment and proteomic analysis from clinically relevant samples

(2019) Rebecca E. Lane et al.   PROTEOMICS

High sensitivity detection of extracellular vesicles immune-captured from urine by conventional flow cytometry

(2019) Carmen Campos-Silva et al.   Scientific Reports

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

(2019) Carine Z. J. Lim et al.   Nature Communications

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients

(2019) Diana J. Cha et al.   Frontiers in Neuroscience

Single molecule characterization of individual extracellular vesicles from pancreatic cancer

(2019) Kathleen M. Lennon et al.   Journal of Extracellular Vesicles

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

(2017) Mariana A. de Godoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease

(2017) Tingting Zheng et al.   Frontiers in Aging Neuroscience

An integrated double-filtration microfluidic device for isolation, enrichment and quantification of urinary extracellular vesicles for detection of bladder cancer

(2017) Li-Guo Liang et al.   Scientific Reports

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

(2016) Mark A. Rider et al.   Scientific Reports

Digital Detection of Exosomes by Interferometric Imaging

(2016) George G. Daaboul et al.   Scientific Reports

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers

(2015) Giovanni Lugli et al.   PLoS One

Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

(2014) L Cheng et al.   MOLECULAR PSYCHIATRY

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microfluidic filtration system to isolate extracellular vesicles from blood

(2012) Ryan T. Davies et al.   LAB ON A CHIP

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY