Ecology and Evolutionary Biology of Hindering Phage Therapy: The Phage Tolerance vs. Phage Resistance of Bacterial Biofilms

Pseudomonas aeruginosa Resists Phage Infection via Eavesdropping on Indole Signaling

(2023) Guanhua Xuan et al.   Microbiology Spectrum

Bacterial biofilm infections, their resistance to antibiotics therapy and current treatment strategies

(2022) Anirudh Singh et al.   Biomedical Materials

Phage therapy of wound-associated infections

(2022) Anna Zyman et al.   FOLIA MICROBIOLOGICA

Tolerance and resistance of microbial biofilms

(2022) Oana Ciofu et al.   NATURE REVIEWS MICROBIOLOGY

Outer Membrane Vesicles (OMVs) of Pseudomonas aeruginosa Provide Passive Resistance but Not Sensitization to LPS-Specific Phages

(2022) Daria Augustyniak et al.   Viruses-Basel

Genomic Analysis of Molecular Bacterial Mechanisms of Resistance to Phage Infection

(2022) Antón Ambroa et al.   Frontiers in Microbiology

Filamentous prophage capsid proteins contribute to superinfection exclusion and phage defence in Pseudomonas aeruginosa

(2022) Weiquan Wang et al.   ENVIRONMENTAL MICROBIOLOGY

Isolation and characterization of vB_XciM_LucasX, a new jumbo phage that infects Xanthomonas citri and Xanthomonas fuscans

(2022) Vinícius Marquioni et al.   PLoS One

An overview of the current state of phage therapy for the treatment of biofilm-related infections

(2022) Diana P Pires et al.   Current Opinion in Virology

Mitigation of evolved bacterial resistance to phage therapy

(2022) Clara Torres-Barceló et al.   Current Opinion in Virology

Antitoxin CrlA of CrlTA Toxin–Antitoxin System in a Clinical Isolate Pseudomonas aeruginosa Inhibits Lytic Phage Infection

(2022) Muyang Ni et al.   Frontiers in Microbiology

Population Dynamics of a Two Phages–One Host Infection System Using Escherichia coli Strain ECOR57 and Phages vB_EcoP_SU10 and vB_EcoD_SU57

(2022) Shazeeda Koonjan et al.   Pharmaceuticals

Antibiotic Exposure Leads to Reduced Phage Susceptibility in Vancomycin Intermediate Staphylococcus aureus (VISA)

(2022) Shawna McCallin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reversible bacteriophage resistance by shedding the bacterial cell wall

(2022) Véronique Ongenae et al.   Open Biology

Hypoxia Increases the Tempo of Phage Resistance and Mutational Bottlenecking of Pseudomonas aeruginosa

(2022) Ashley R. Schumann et al.   Frontiers in Microbiology

Bacteriophage and Bacterial Susceptibility, Resistance, and Tolerance to Antibiotics

(2022) Qingquan Chen et al.   Pharmaceutics

Reassessment of Historical Clinical Trials Supports the Effectiveness of Phage Therapy

(2022) Luigi Marongiu et al.   CLINICAL MICROBIOLOGY REVIEWS

Recent trends in T7 phage application in diagnosis and treatment of various diseases

(2022) Tong Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Historical Contingency Drives Compensatory Evolution and Rare Reversal of Phage Resistance

(2022) Reena Debray et al.   MOLECULAR BIOLOGY AND EVOLUTION

The biofilm matrix: multitasking in a shared space

(2022) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Characterization of Phage Resistance and Their Impacts on Bacterial Fitness in Pseudomonas aeruginosa

(2022) Na Li et al.   Microbiology Spectrum

L-Form Switching in Escherichia coli as a Common β-Lactam Resistance Mechanism

(2022) Aleksandra Petrovic Fabijan et al.   Microbiology Spectrum

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

(2021) Gracja Topka-Bielecka et al.   Antibiotics-Basel

Disinfectant resistance in bacteria: Mechanisms, spread, and resolution strategies

(2021) Chaoyu Tong et al.   ENVIRONMENTAL RESEARCH

Bursting out: linking changes in nanotopography and biomechanical properties of biofilm-forming Escherichia coli to the T4 lytic cycle

(2021) Shiju Abraham et al.   npj Biofilms and Microbiomes

Bacteriophages as tools for biofilm biocontrol in different fields

(2021) Camila Mendes Figueiredo et al.   BIOFOULING

Water in bacterial biofilms: pores and channels, storage and transport functions

(2021) Kecheng Quan et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Characterization and protective effects of lytic bacteriophage pAh6.2TG against a pathogenic multidrug‐resistant Aeromonas hydrophila in Nile tilapia ( Oreochromis niloticus )

(2021) Le Thanh Dien et al.   Transboundary and Emerging Diseases

Black box of phage–bacterium interactions: exploring alternative phage infection strategies

(2021) Sari Mäntynen et al.   Open Biology

Evolution of Bacterial Cross-Resistance to Lytic Phages and Albicidin Antibiotic

(2021) Kaitlyn E. Kortright et al.   Frontiers in Microbiology

Bacteria elicit a phage tolerance response subsequent to infection of their neighbors

(2021) Elhanan Tzipilevich et al.   EMBO JOURNAL

Autoinducer‐2‐mediated quorum‐sensing system resists T4 phage infection in Escherichia coli

(2021) Yafang Ding et al.   JOURNAL OF BASIC MICROBIOLOGY

Bio-control of O157:H7, and colistin-resistant MCR-1-positive Escherichia coli using a new designed broad host range phage cocktail

(2021) Khashayar Shahin et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages

(2021) Fatima Aysha Hussain et al.   SCIENCE

Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance

(2021) Natalia C. Rosas et al.   TRENDS IN MICROBIOLOGY

Individual bacteria in structured environments rely on phenotypic resistance to phage

(2021) Erin L. Attrill et al.   PLOS BIOLOGY

Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application

(2021) Katarzyna M. Danis-Wlodarczyk et al.   Antibiotics-Basel

Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?

(2021) Stephen Abedon et al.   Pharmaceuticals

Phage Cocktail Development for Bacteriophage Therapy: Toward Improving Spectrum of Activity Breadth and Depth

(2021) Stephen T. Abedon et al.   Pharmaceuticals

The arms race between bacteria and their phage foes

(2020) Hannah G. Hampton et al.   NATURE

Bacteriophages for Chronic Wound Treatment: From Traditional to Novel Delivery Systems

(2020) Ana M. Pinto et al.   Viruses-Basel

Quantitative Models of Phage-Antibiotic Combination Therapy

(2020) Rogelio A. Rodriguez-Gonzalez et al.   mSystems

Topical application of bacteriophages for treatment of wound infections

(2020) Rachel Yoon Kyung Chang et al.   Translational Research

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

(2020) Anna Lopatina et al.   Annual Review of Virology

Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria

(2020) Emilia L. Simmons et al.   mSystems

Ecology and evolution of antimicrobial resistance in bacterial communities

(2020) Michael J. Bottery et al.   ISME Journal

Antimycobacterial Potential of Mycobacteriophage Under Disease-Mimicking Conditions

(2020) Yeswanth Chakravarthy Kalapala et al.   Frontiers in Microbiology

P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination

(2019) Karoline Henriksen et al.   Pathogens and Disease

Fighting Pathogenic Bacteria on Two Fronts: Phages and Antibiotics as Combined Strategy

(2019) Thaysa Leite Tagliaferri et al.   Frontiers in Cellular and Infection Microbiology

The genera of bacteriophages and their receptors are the major determinants of host range

(2019) Yilmaz Emre Gencay et al.   ENVIRONMENTAL MICROBIOLOGY

(Ph)ighting Phages: How Bacteria Resist Their Parasites

(2019) Jakob T. Rostøl et al.   Cell Host & Microbe

Resistance is not futile: bacterial ‘innate’ and CRISPR-Cas ‘adaptive’ immune systems

(2019) Peter C. Fineran   MICROBIOLOGY-SGM

Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms

(2019) Jing Yan et al.   Cell Host & Microbe

Purely Polysaccharide-Based Biofilm Matrix Provides Size-Selective Diffusion Barriers for Nanoparticles and Bacteriophages

(2019) Valentin Dunsing et al.   BIOMACROMOLECULES

Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy

(2019) Anca M Segall et al.   CURRENT OPINION IN MICROBIOLOGY

Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies

(2019) Krystyna Dąbrowska et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire

(2019) Eugene V. Koonin et al.   NATURE REVIEWS GENETICS

Bacteriophage Therapeutics: A Primer for Clinicians on Phage‐Antibiotic Combinations

(2019) Taylor Morrisette et al.   PHARMACOTHERAPY

Use of phage therapy to treat long-standing, persistent, or chronic bacterial infections

(2018) Stephen T. Abedon   ADVANCED DRUG DELIVERY REVIEWS

Bacteriophage-based strategies for biofouling control in ultrafiltration: In situ biofouling mitigation, biocidal additives and biofilm cleanser

(2018) Wen Ma et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica

(2018) Saskia Neuert et al.   Frontiers in Microbiology

Bacteriophage Sb-1 enhances antibiotic activity against biofilm, degrades exopolysaccharide matrix and targets persisters of Staphylococcus aureus

(2018) Tamta Tkhilaishvili et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Analysis of Different Parameters Affecting Diffusion, Propagation and Survival of Staphylophages in Bacterial Biofilms

(2018) Silvia González et al.   Frontiers in Microbiology

Spatial structure facilitates the accumulation and persistence of antibiotic-resistant mutants in biofilms

(2018) Michael T. France et al.   Evolutionary Applications

Biofilm-related disease

(2017) Jose Luis Del Pozo   Expert Review of Anti-Infective Therapy

Phage mobility is a core determinant of phage–bacteria coexistence in biofilms

(2017) Matthew Simmons et al.   ISME Journal

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

A growing microcolony can survive and support persistent propagation of virulent phages

(2017) Rasmus Skytte Eriksen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phage Inhibit Pathogen Dissemination by Targeting Bacterial Migrants in a Chronic Infection Model

(2017) Sophie E. Darch et al.   mBio

Novel “Superspreader” Bacteriophages Promote Horizontal Gene Transfer by Transformation

(2017) Eric C. Keen et al.   mBio

Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients

(2017) Guimin Zhang et al.   International Forum of Allergy & Rhinology

Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

(2017) Robert M Cooper et al.   eLife

Dynamic biofilm architecture confers individual and collective mechanisms of viral protection

(2017) Lucia Vidakovic et al.   Nature Microbiology

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Quorum sensing controls thePseudomonas aeruginosaCRISPR-Cas adaptive immune system

(2016) Nina M. Høyland-Kroghsbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Rationale for Phages as Complements of Antibiotics

(2016) Clara Torres-Barceló et al.   TRENDS IN MICROBIOLOGY

Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages

(2016) M. Mozammel Hoque et al.   Scientific Reports

Bacteriophage T4 Infection of Stationary Phase E. coli: Life after Log from a Phage Perspective

(2016) Daniel Bryan et al.   Frontiers in Microbiology

Vibriophages Differentially Influence Biofilm Formation by Vibrio anguillarum Strains

(2015) Demeng Tan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biofilm-specific antibiotic tolerance and resistance

(2015) I. Olsen   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Quorum Sensing Determines the Choice of Antiphage Defense Strategy in Vibrio anguillarum

(2015) Demeng Tan et al.   mBio

Virulence reduction in bacteriophage resistant bacteria

(2015) Marcela León et al.   Frontiers in Microbiology

Phenotypic Resistance and the Dynamics of Bacterial Escape from Phage Control

(2014) James J. Bull et al.   PLoS One

A Quorum-Sensing-Induced Bacteriophage Defense Mechanism

(2013) N. M. Hoyland-Kroghsbo et al.   mBio

Increased Mutability of Staphylococci in Biofilms as a Consequence of Oxidative Stress

(2012) Victoria J. Ryder et al.   PLoS One

Coexistence of phage and bacteria on the boundary of self-organized refuges

(2012) S. Heilmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial Vulnerability: Bacterial Arrangements, Microcolonies, and Biofilms as Responses to Low Rather than High Phage Densities

(2012) Stephen T. Abedon   Viruses-Basel

Resistance of bacterial biofilms to disinfectants: a review

(2011) A. Bridier et al.   BIOFOULING

Diffusion of bacteriophages through artificial biofilm models

(2011) Jun Hu et al.   BIOTECHNOLOGY PROGRESS

Contribution of bacterial outer membrane vesicles to innate bacterial defense

(2011) Andrew J Manning et al.   BMC MICROBIOLOGY

Phage Therapy Pharmacology

(2010) Stephen Abedon et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The role ofrpoSgene and quorum-sensing system in ofloxacin tolerance inPseudomonas aeruginosa

(2009) Shizuo Kayama et al.   FEMS MICROBIOLOGY LETTERS

Role of Mutation in Pseudomonas aeruginosa Biofilm Development

(2009) Tim C. R. Conibear et al.   PLoS One

Fluorescence Correlation Spectroscopy To Study Diffusion and Reaction of Bacteriophages inside Biofilms

(2008) R. Briandet et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Stochastic Receptor Expression Allows Sensitive Bacteria to Evade Phage Attack. Part I: Experiments

(2008) E. Chapman-McQuiston et al.   BIOPHYSICAL JOURNAL

The Use of Phages for the Removal of Infectious Biofilms

(2008) J. Azeredo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Increased mutability of Pseudomonas aeruginosa in biofilms

(2008) K. Driffield et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Endogenous oxidative stress produces diversity and adaptability in biofilm communities

(2008) B. R. Boles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nongenetic Individuality in the Host–Phage Interaction

(2008) Sivan Pearl et al.   PLOS BIOLOGY