Persistent bacterial infections and persister cells

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

ATP-Dependent Persister Formation in Escherichia coli

(2017) Yue Shan et al.   mBio

Persistence to anti-cancer treatments in the stationary to proliferating transition

(2016) Sivan Pearl Mizrahi et al.   CELL CYCLE

The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation

(2016) Ethel Bayer-Santos et al.   Cell Host & Microbe

Persistent Infections by NontyphoidalSalmonellain Humans: Epidemiology and Genetics

(2016) Alex Marzel et al.   CLINICAL INFECTIOUS DISEASES

Molecular mechanisms and clinical implications of bacterial persistence

(2016) Joran Elie Michiels et al.   DRUG RESISTANCE UPDATES

NH125 kills methicillin-resistantStaphylococcus aureuspersisters by lipid bilayer disruption

(2016) Wooseong Kim et al.   Future Medicinal Chemistry

Membrane-targeting AM-0016 kills mycobacterial persisters and shows low propensity for resistance development

(2016) Devika Mukherjee et al.   Future Microbiology

Elucidating population-wide mycobacterial replication dynamics at the single-cell level

(2016) Jacoba M. Mouton et al.   MICROBIOLOGY-SGM

A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA

(2016) Angela M. Cheverton et al.   MOLECULAR CELL

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

(2016) Yingying Pu et al.   MOLECULAR CELL

Bacterial persistence is an active σSstress response to metabolic flux limitation

(2016) Jakub Leszek Radzikowski et al.   Molecular Systems Biology

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Chlamydia cell biology and pathogenesis

(2016) Cherilyn Elwell et al.   NATURE REVIEWS MICROBIOLOGY

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

(2016) Justin D. Radolf et al.   NATURE REVIEWS MICROBIOLOGY

Mechanisms of bacterial persistence during stress and antibiotic exposure

(2016) Alexander Harms et al.   SCIENCE

Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth

(2016) Nityananda Chowdhury et al.   Scientific Reports

Persister formation in Staphylococcus aureus is associated with ATP depletion

(2016) Brian P. Conlon et al.   Nature Microbiology

Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae

(2016) Victor I. Band et al.   Nature Microbiology

Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids

(2016) Vera Pader et al.   Nature Microbiology

Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence

(2016) Bram Van den Bergh et al.   Nature Microbiology

A Novel Point Mutation Promotes Growth Phase-Dependent Daptomycin Tolerance in Staphylococcus aureus

(2015) Lukas Mechler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms

(2015) Giulia Manina et al.   Cell Host & Microbe

Persister Heterogeneity Arising from a Single Metabolic Stress

(2015) Stephanie M. Amato et al.   CURRENT BIOLOGY

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

HipBA–promoter structures reveal the basis of heritable multidrug tolerance

(2015) Maria A. Schumacher et al.   NATURE

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

(2015) Sophie M. Lehar et al.   NATURE

Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases

(2015) Elsa Germain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Basis of Persister Tolerance to Aminoglycosides in Escherichia coli

(2015) Yue Shan et al.   mBio

Stationary-Phase Persisters to Ofloxacin Sustain DNA Damage and Require Repair Systems Only during Recovery

(2015) Katherine G. Völzing et al.   mBio

Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells

(2015) Damián Lobato-Márquez et al.   Scientific Reports

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

(2015) Alexander Harms et al.   Cell Reports

Engineering Persister-Specific Antibiotics with Synergistic Antimicrobial Functions

(2014) Nathan W. Schmidt et al.   ACS Nano

Art-175 Is a Highly Efficient Antibacterial against Multidrug-Resistant Strains and Persisters of Pseudomonas aeruginosa

(2014) Yves Briers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy

(2014) Beatrice Claudi et al.   CELL

Bacteria Fighting Back: How Pathogens Target and Subvert the Host Innate Immune System

(2014) L. Evan Reddick et al.   MOLECULAR CELL

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

(2014) Ofer Fridman et al.   NATURE

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?

(2014) Kimberley L. Painter et al.   TRENDS IN MICROBIOLOGY

Bacterial persisters: formation, eradication, and experimental systems

(2014) Sophie Helaine et al.   TRENDS IN MICROBIOLOGY

The role of metabolism in bacterial persistence

(2014) Stephanie M. Amato et al.   Frontiers in Microbiology

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Microbial Persistence and the Road to Drug Resistance

(2013) Nadia R. Cohen et al.   Cell Host & Microbe

Bacterial Obg proteins: GTPases at the nexus of protein and DNA synthesis

(2013) Cyrielle Kint et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Tolerance of Escherichia coli to Fluoroquinolone Antibiotics Depends on Specific Components of the SOS Response Pathway

(2013) A. Theodore et al.   GENETICS

Biofilm Formation Avoids Complement Immunity and Phagocytosis of Streptococcus pneumoniae

(2013) Mirian Domenech et al.   INFECTION AND IMMUNITY

Persistent Staphylococcus aureus Bacteremia

(2013) Yong Pil Chong et al.   MEDICINE

Molecular Mechanism of Bacterial Persistence by HipA

(2013) Elsa Germain et al.   MOLECULAR CELL

Metabolic Control of Persister Formation in Escherichia coli

(2013) Stephanie M. Amato et al.   MOLECULAR CELL

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

(2013) Daniel Castro-Roa et al.   Nature Chemical Biology

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

(2013) Nina R. Salama et al.   NATURE REVIEWS MICROBIOLOGY

Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype

(2013) R. A. Fasani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

(2013) Y. Wakamoto et al.   SCIENCE

HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase

(2013) Ilana Kaspy et al.   Nature Communications

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response

(2013) Sarah Schmidt Grant et al.   Virulence

Review article: biofilm formation by Helicobacter pylori as a target for eradication of resistant infection

(2012) G. Cammarota et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

High-Resolution Single Nucleotide Polymorphism Analysis Distinguishes Recrudescence and Reinfection in Recurrent Invasive Nontyphoidal Salmonella Typhimurium Disease

(2012) Chinyere K. Okoro et al.   CLINICAL INFECTIOUS DISEASES

Persister-promoting bacterial toxin TisB produces anion-selective pores in planar lipid bilayers

(2012) Philip A. Gurnev et al.   FEBS LETTERS

Conditional cooperativity in toxin–antitoxin regulation prevents random toxin activation and promotes fast translational recovery

(2012) Ilaria Cataudella et al.   NUCLEIC ACIDS RESEARCH

Reverting Antibiotic Tolerance of Pseudomonas aeruginosa PAO1 Persister Cells by (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one

(2012) Jiachuan Pan et al.   PLoS One

Control of Bacterial Persister Cells by Trp/Arg-Containing Antimicrobial Peptides

(2011) Xi Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Regulation of growth and death in Escherichia coli by toxin–antitoxin systems

(2011) Yoshihiro Yamaguchi et al.   NATURE REVIEWS MICROBIOLOGY

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

(2011) D. Nguyen et al.   SCIENCE

Best Strategies in Recurrent or Persistent Clostridium difficile Infection

(2011) Christine S. Cocanour   Surgical Infections

Intracellular Lifestyles and Immune Evasion Strategies of UropathogenicEscherichia coli

(2010) David A. Hunstad et al.   Annual Review of Microbiology

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Biofilms in chronic infections – a matter of opportunity – monospecies biofilms in multispecies infections

(2010) Mette Burmølle et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: A single-center experience

(2010) Anthony De Soyza et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Long-term impacts of antibiotic exposure on the human intestinal microbiota

(2010) C. Jernberg et al.   MICROBIOLOGY-SGM

Automated imaging with ScanLag reveals previously undetectable bacterial growth phenotypes

(2010) Irit Levin-Reisman et al.   NATURE METHODS

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of intracellular bacterial replication at the single cell level

(2010) Sophie Helaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

(2010) Tobias Dörr et al.   PLOS BIOLOGY

Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans

(2009) M. D. LaFleur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Chromosomal Toxin Gene yafQ Is a Determinant of Multidrug Tolerance for Escherichia coli Growing in a Biofilm

(2009) J. J. Harrison et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diagnosis and Treatment of Acute or Persistent Diarrhea

(2009) Sean W. Pawlowski et al.   GASTROENTEROLOGY

Regulation of the mazEF Toxin-Antitoxin Module in Staphylococcus aureus and Its Impact on sigB Expression

(2009) N. P. Donegan et al.   JOURNAL OF BACTERIOLOGY

Overexpression of MazFSa in Staphylococcus aureus Induces Bacteriostasis by Selectively Targeting mRNAs for Cleavage

(2009) Z. Fu et al.   JOURNAL OF BACTERIOLOGY

Three new RelE-homologous mRNA interferases ofEscherichia colidifferentially induced by environmental stresses

(2009) Mikkel Christensen-Dalsgaard et al.   MOLECULAR MICROBIOLOGY

SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli

(2009) Tobias Dörr et al.   PLoS Genetics

Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli

(2008) S. Hansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Medical biofilms

(2008) James D. Bryers   BIOTECHNOLOGY AND BIOENGINEERING

RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus

(2008) Shu Y. Queck et al.   MOLECULAR CELL

Messenger RNA interferase RelE controlsrelBEtranscription by conditional cooperativity

(2008) Martin Overgaard et al.   MOLECULAR MICROBIOLOGY

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS