Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies

Role of the microbiome in human development

(2019) Maria Gloria Dominguez-Bello et al.   GUT

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes

(2019) Anjelique F. Schulfer et al.   ISME Journal

Adjunct phage treatment enhances the effectiveness of low antibiotic concentration against Staphylococcus aureus biofilms in vitro

(2019) James Dickey et al.   PLoS One

P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination

(2019) Karoline Henriksen et al.   Pathogens and Disease

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

(2019) Krystyna Dąbrowska   MEDICINAL RESEARCH REVIEWS

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

(2019) Kaitlyn E. Kortright et al.   Cell Host & Microbe

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Current State of Compassionate Phage Therapy

(2019) McCallin et al.   Viruses-Basel

Bacteriophage Therapy of Chronic Nonhealing Wound: Clinical Study

(2019) Pooja Gupta et al.   International Journal of Lower Extremity Wounds

Bacteriophages engineered to display foreign peptides may become short‐circulating phages

(2019) Katarzyna Hodyra‐Stefaniak et al.   Microbial Biotechnology

Use of phage therapy to treat long-standing, persistent, or chronic bacterial infections

(2018) Stephen T. Abedon   ADVANCED DRUG DELIVERY REVIEWS

Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

(2018) Evelien M. Adriaenssens et al.   ARCHIVES OF VIROLOGY

Antimicrobial effect of commercial phage preparation Stafal® on biofilm and planktonic forms of methicillin-resistant Staphylococcus aureus

(2018) Milada Dvořáčková et al.   FOLIA MICROBIOLOGICA

Phage Therapy Faces Evolutionary Challenges

(2018) Clara Torres-Barceló   Viruses-Basel

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains

(2018) Christine Rohde et al.   Viruses-Basel

Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

(2018) Frank Oechslin   Viruses-Basel

Isolation, characterization and efficacy of phage MJ2 against biofilm forming multi-drug resistant Enterobacter cloacae

(2018) Muhsin Jamal et al.   FOLIA MICROBIOLOGICA

Extensive impact of non-antibiotic drugs on human gut bacteria

(2018) Lisa Maier et al.   NATURE

Evaluation of Bacteriophage Anti-Biofilm Activity for Potential Control of Orthopedic Implant-Related Infections Caused by Staphylococcus Aureus

(2018) Jodie Morris et al.   Surgical Infections

Adapted Bacteriophages for Treating Urinary Tract Infections

(2018) Aleksandre Ujmajuridze et al.   Frontiers in Microbiology

Identification of novel bacteriophage vB_EcoP-EG1 with lytic activity against planktonic and biofilm forms of uropathogenic Escherichia coli

(2018) Yu Gu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Our missing microbes: Short-term antibiotic courses have long-term consequences

(2018) M. J. BLASER   CLEVELAND CLINIC JOURNAL OF MEDICINE

Preserving microbial diversity

(2018) Maria G. Dominguez Bello et al.   SCIENCE

Clinical Indications and Compassionate Use of Phage Therapy: Personal Experience and Literature Review with a Focus on Osteoarticular Infections

(2018) Olivier Patey et al.   Viruses-Basel

Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System

(2018) Jonas Van Belleghem et al.   Viruses-Basel

Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles

(2018) Lucy L. Furfaro et al.   Frontiers in Cellular and Infection Microbiology

Salvage ‘DAIR’ (debridement, antibiotics and implant retention) with local injection of a selected cocktail of bacteriophages: is it an option for an elderly patient with relapsing S. aureus prosthetic-joint infection?

(2018) Tristan Ferry et al.   Open Forum Infectious Diseases

Antimicrobial assessment of phage therapy using a porcine model of biofilm infection

(2018) C. Milho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Antiphage activity of sera during phage therapy in relation to its outcome

(2017) Marzanna Łusiak-Szelachowska et al.   Future Microbiology

The antibiotic resistance crisis, with a focus on the United States

(2017) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Modeling the synergistic elimination of bacteria by phage and the innate immune system

(2017) Chung Yin (Joey) Leung et al.   JOURNAL OF THEORETICAL BIOLOGY

Anti-CRISPR: discovery, mechanism and function

(2017) April Pawluk et al.   NATURE REVIEWS MICROBIOLOGY

Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules

(2017) Marlon G. Lawrence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers

(2017) Sophie Nguyen et al.   mBio

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Means to Facilitate the Overcoming of Gastric Juice Barrier by a Therapeutic Staphylococcal Bacteriophage A5/80

(2017) Ryszard Międzybrodzki et al.   Frontiers in Microbiology

Microencapsulation with alginate/CaCO3: A strategy for improved phage therapy

(2017) Joan Colom et al.   Scientific Reports

Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages

(2017) Jonas D. Van Belleghem et al.   Scientific Reports

In VivoApplication of Bacteriophage as a Potential Therapeutic Agent To Control OXA-66-Like Carbapenemase-Producing Acinetobacter baumannii Strains Belonging to Sequence Type 357

(2016) Jongsoo Jeon et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Advances in the transepithelial transport of nanoparticles

(2016) Miaorong Yu et al.   DRUG DISCOVERY TODAY

Bacteriophages to reduce gut carriage of antibiotic resistant uropathogens with low impact on microbiota composition

(2016) Matthieu Galtier et al.   ENVIRONMENTAL MICROBIOLOGY

Oral application ofEscherichia colibacteriophage: safety tests in healthy and diarrheal children from Bangladesh

(2016) Shafiqul Alam Sarker et al.   ENVIRONMENTAL MICROBIOLOGY

Inhaled phage therapy: a promising and challenging approach to treat bacterial respiratory infections

(2016) Elsa Bodier-Montagutelli et al.   Expert Opinion on Drug Delivery

Intranasal treatment with bacteriophage rescues mice fromAcinetobacter baumannii-mediated pneumonia

(2016) Yong Wang et al.   Future Microbiology

Extending the lifetime of antibiotics: how can phage therapy help?

(2016) Benjamin K Chan et al.   Future Microbiology

Inhalation Study of Mycobacteriophage D29 Aerosol for Mice by Endotracheal Route and Nose-Only Exposure

(2016) Ke-yang Liu et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Genetically Engineered Phages: a Review of Advances over the Last Decade

(2016) Diana P. Pires et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Therapeutic effect of Pseudomonas aeruginosa phage YH30 on mink hemorrhagic pneumonia

(2016) Jingmin Gu et al.   VETERINARY MICROBIOLOGY

Potential of phage cocktails in the inactivation of Enterobacter cloacae —An in vitro study in a buffer solution and in urine samples

(2016) S. Pereira et al.   VIRUS RESEARCH

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

(2016) Amy Langdon et al.   Genome Medicine

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

Bacteriophages as Therapeutic and Prophylactic Means: Summary of the Soviet and Post Soviet Experiences

(2016) Nina Chanishvili   Current Drug Delivery

Correlations of Host Genetics and Gut Microbiome Composition

(2016) Krystyna Dąbrowska et al.   Frontiers in Microbiology

T4 Phage Tail Adhesin Gp12 Counteracts LPS-Induced Inflammation In Vivo

(2016) Paulina Miernikiewicz et al.   Frontiers in Microbiology

Phage Therapy: Combating Infections with Potential for Evolving from Merely a Treatment for Complications to Targeting Diseases

(2016) Andrzej Górski et al.   Frontiers in Microbiology

More Is Better: Selecting for Broad Host Range Bacteriophages

(2016) Alexa Ross et al.   Frontiers in Microbiology

Bacteriophage treatment of intransigent diabetic toe ulcers: a case series

(2016) R. Fish et al.   Journal of Wound Care

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

Oral Delivery Systems for Encapsulated Bacteriophages Targeted at Escherichia coli O157:H7 in Feedlot Cattle

(2016) K. STANFORD et al.   JOURNAL OF FOOD PROTECTION

Encapsulation of Bacteriophage in Liposome Accentuates Its Entry in to Macrophage and Shields It from Neutralizing Antibodies

(2016) Saloni Singla et al.   PLoS One

Experimental Phage Therapy for Burkholderia pseudomallei Infection

(2016) Ong Guang-Han et al.   PLoS One

Pharmacokinetics and Penetration of Ceftazidime and Avibactam into Epithelial Lining Fluid in Thigh- and Lung-Infected Mice

(2015) Johanna Berkhout et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Liposome-Encapsulated Bacteriophages for Enhanced Oral Phage Therapy against Salmonella spp.

(2015) Joan Colom et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A non-chromatographic method for the removal of endotoxins from bacteriophages

(2015) Steven D. Branston et al.   BIOTECHNOLOGY AND BIOENGINEERING

Antibiotics, Pediatric Dysbiosis, and Disease

(2015) Pajau Vangay et al.   Cell Host & Microbe

Phages targeting infected tissues: novel approach to phage therapy

(2015) Andrzej Górski et al.   Future Microbiology

Re-establishing a place for phage therapy in western medicine

(2015) Elizabeth Martin Kutter et al.   Future Microbiology

Bacteriophage-Loaded Nanostructured Lipid Carrier: Improved Pharmacokinetics Mediates Effective Resolution ofKlebsiella pneumoniae–Induced Lobar Pneumonia

(2015) Saloni Singla et al.   JOURNAL OF INFECTIOUS DISEASES

Dark Matter of the Biosphere: the Amazing World of Bacteriophage Diversity

(2015) Graham F. Hatfull   JOURNAL OF VIROLOGY

The lymph node filter revealed

(2015) Miroslav Hons et al.   NATURE IMMUNOLOGY

Quality and Safety Requirements for Sustainable Phage Therapy Products

(2015) Jean-Paul Pirnay et al.   PHARMACEUTICAL RESEARCH

Oral Application of T4 Phage Induces Weak Antibody Production in the Gut and in the Blood

(2015) Joanna Majewska et al.   Viruses-Basel

Mammalian Host-Versus-Phage immune response determines phage fate in vivo

(2015) Katarzyna Hodyra-Stefaniak et al.   Scientific Reports

Evaluation of the Efficacy of a Bacteriophage in the Treatment of Pneumonia Induced by Multidrug ResistanceKlebsiella pneumoniaein Mice

(2015) Fang Cao et al.   Biomed Research International

Isolation and Characterization of a “phiKMV-Like” Bacteriophage and Its Therapeutic Effect on Mink Hemorrhagic Pneumonia

(2015) Zhenhui Cao et al.   PLoS One

Removal of Endotoxins from Bacteriophage Preparations by Extraction with Organic Solvents

(2015) Bożena Szermer-Olearnik et al.   PLoS One

Aerosol Phage Therapy Efficacy in Burkholderia cepacia Complex Respiratory Infections

(2014) Diana D. Semler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Detection and Quantification of Flavobacterium psychrophilum-Specific BacteriophagesIn Vivoin Rainbow Trout upon Oral Administration: Implications for Disease Control in Aquaculture

(2014) Rói Hammershaimb Christiansen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Integrative Human Microbiome Project: Dynamic Analysis of Microbiome-Host Omics Profiles during Periods of Human Health and Disease

(2014)   Cell Host & Microbe

Comparative analysis of different oral approaches to treat Vibrio cholerae infection in adult mice

(2014) Abhishek Jaiswal et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Viruses versus bacteria--novel approaches to phage therapy as a tool against multidrug-resistant pathogens

(2014) T. M. Viertel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bacteriophage Therapy of a Vibrio parahaemolyticus Infection Caused by a Multiple-Antibiotic–Resistant O3:K6 Pandemic Clinical Strain

(2014) Jin Woo Jun et al.   JOURNAL OF INFECTIOUS DISEASES

Immunogenicity Studies of Proteins Forming the T4 Phage Head Surface

(2014) K. D browska et al.   JOURNAL OF VIROLOGY

Experimental phage therapy against lethal lung-derived septicemia caused by Staphylococcus aureus in mice

(2014) Iyo Takemura-Uchiyama et al.   MICROBES AND INFECTION

Taking Bacteriophage Therapy Seriously: A Moral Argument

(2014) Gilbert Verbeken et al.   Biomed Research International

The habits of highly effective phages: population dynamics as a framework for identifying therapeutic phages

(2014) James J. Bull et al.   Frontiers in Microbiology

Remarkable Mechanisms in Microbes to Resist Phage Infections

(2014) Ron L. Dy et al.   Annual Review of Virology

PredictingIn VivoEfficacy of Therapeutic Bacteriophages Used To Treat Pulmonary Infections

(2013) Marine Henry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phage cocktails and the future of phage therapy

(2013) Benjamin K Chan et al.   Future Microbiology

Revenge of the phages: defeating bacterial defences

(2013) Julie E. Samson et al.   NATURE REVIEWS MICROBIOLOGY

Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption

(2013) S. Attili-Qadri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cocktail of in vitro efficient phages is not a guarantee for in vivo therapeutic results against avian colibacillosis

(2013) Jessica Tsonos et al.   VETERINARY MICROBIOLOGY

Safety analysis of a Russian phage cocktail: From MetaGenomic analysis to oral application in healthy human subjects

(2013) Shawna McCallin et al.   VIROLOGY

A Quorum-Sensing-Induced Bacteriophage Defense Mechanism

(2013) N. M. Hoyland-Kroghsbo et al.   mBio

Importance of prophages to evolution and virulence of bacterial pathogens

(2013) Louis-Charles Fortier et al.   Virulence

Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model

(2013) Gabriela Trigo et al.   PLoS Neglected Tropical Diseases

Tumor-Penetrating Peptides

(2013) Tambet Teesalu et al.   Frontiers in Oncology

Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles

(2012) Erkki Ruoslahti   ADVANCED MATERIALS

Efficacy of Bacteriophage Therapy in Experimental Sepsis and Meningitis Caused by a Clone O25b:H4-ST131 Escherichia coli Strain Producing CTX-M-15

(2012) Flavie Pouillot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A test for the “physiological phagemia” hypothesis—natural intestinal coliphages do not penetrate to the blood in horses

(2012) M. Letarova et al.   FOLIA MICROBIOLOGICA

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Going viral: next-generation sequencing applied to phage populations in the human gut

(2012) Alejandro Reyes et al.   NATURE REVIEWS MICROBIOLOGY

Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh

(2012) Shafiqul Alam Sarker et al.   VIROLOGY

Identification of peptide sequences that target to the brain using in vivo phage display

(2011) Jingwei Li et al.   AMINO ACIDS

Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides

(2011) Jingwei Li et al.   BIOMATERIALS

Intestinal colonization by enteroaggregative Escherichia coli supports long-term bacteriophage replication in mice

(2011) Damien Maura et al.   ENVIRONMENTAL MICROBIOLOGY

The influence of external factors on bacteriophages—review

(2011) E. Jończyk et al.   FOLIA MICROBIOLOGICA

Role of bacteriophage-encoded exotoxins in the evolution of bacterial pathogens

(2011) Veronica Casas et al.   Future Microbiology

Bacteriophage therapy for refractory Pseudomonas aeruginosa urinary tract infection

(2011) A. Khawaldeh et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Antibacterial efficacy of lytic Pseudomonas bacteriophage in normal and neutropenic mice models

(2011) Birendra R. Tiwari et al.   JOURNAL OF MICROBIOLOGY

Recent advances in bacteriophage therapy: how delivery routes, formulation, concentration and timing influence the success of phage therapy

(2011) Elizabeth M. Ryan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bacteriophages and cancer

(2010) Paulina Budynek et al.   ARCHIVES OF MICROBIOLOGY

Designing Phage Therapeutics

(2010) Lawrence Goodridge   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Phage Therapy Pharmacology

(2010) Stephen Abedon et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Bacteriophage for Biocontrol of Foodborne Pathogens: Calculations and Considerations

(2010) Steven Hagens et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Phage Choice, Isolation, and Preparation for Phage Therapy

(2010) Jason Gill et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Bacteriophages Can Treat and PreventPseudomonas aeruginosaLung Infections

(2010) Laurent Debarbieux et al.   JOURNAL OF INFECTIOUS DISEASES

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

The Phage Therapy Paradigm: Prêt-à-Porter or Sur-mesure?

(2010) Jean-Paul Pirnay et al.   PHARMACEUTICAL RESEARCH

Immune interference of bacteriophage efficacy when treating colibacillosis in poultry

(2010) W. E. Huff et al.   POULTRY SCIENCE

Paradoxical glomerular filtration of carbon nanotubes

(2010) A. Ruggiero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerosol Spray Treatment with Bacteriophages and Competitive Exclusion Reduces Salmonella Enteritidis Infection in Chickens

(2009) C. Borie et al.   AVIAN DISEASES

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Phage therapy

(2009) John N. Housby et al.   DRUG DISCOVERY TODAY

Convection-enhanced delivery for the treatment of brain tumors

(2009) Waldemar Debinski et al.   Expert Review of Neurotherapeutics

Bacteriophage Therapy ofSalmonella enterica:A Fresh Appraisal of Bacteriophage Therapy

(2009) Rosanna Capparelli et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of Bacteriophage Therapy in a Model ofBurkholderia cenocepaciaPulmonary Infection

(2009) Lisa A. Carmody et al.   JOURNAL OF INFECTIOUS DISEASES

The influence of the mode of administration in the dissemination of three coliphages in chickens

(2009) A. Oliveira et al.   POULTRY SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

T4 phages against Escherichia coli diarrhea: Potential and problems

(2009) Emmanuel Denou et al.   VIROLOGY

In vivo replication of T4 and T7 bacteriophages in germ-free mice colonized with Escherichia coli

(2009) Marietta Weiss et al.   VIROLOGY

Quantitative Models of In Vitro Bacteriophage–Host Dynamics and Their Application to Phage Therapy

(2009) Benjamin J. Cairns et al.   PLoS Pathogens

T-even-related bacteriophages as candidates for treatment of Escherichia coli urinary tract infections

(2008) H. Nishikawa et al.   ARCHIVES OF VIROLOGY

Bacteriophage Treatment Reduces Salmonella Colonization of Infected Chickens

(2008) C. Borie et al.   AVIAN DISEASES

Identification of a peptide sequence that improves transport of macromolecules across the intestinal mucosal barrier targeting goblet cells

(2008) S KANG et al.   JOURNAL OF BIOTECHNOLOGY

Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice

(2008) S. Chhibber et al.   JOURNAL OF MEDICAL MICROBIOLOGY

PEGylation of bacteriophages increases blood circulation time and reduces T-helper type 1 immune response

(2008) Kwang-Pyo Kim et al.   Microbial Biotechnology