The arms race between bacteria and their phage foes

Imprecise Spacer Acquisition Generates CRISPR-Cas Immune Diversity through Primed Adaptation

(2019) Simon A. Jackson et al.   Cell Host & Microbe

Clinical applications of CRISPR-based genome editing and diagnostics

(2019) Dana V. Foss et al.   TRANSFUSION

Enterococcus faecalis Countermeasures Defeat a Virulent Picovirinae Bacteriophage

(2019) Julien Lossouarn et al.   Viruses-Basel

Bacteriophages in Food Applications: From Foe to Friend

(2019) Lisa O'Sullivan et al.   Annual Review of Food Science and Technology

Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR–Cas immunity

(2019) Jakob T. Rostøl et al.   Nature Microbiology

Yet More Evidence of Collusion: a New Viral Defense System Encoded by Gordonia Phage CarolAnn

(2019) Matthew T. Montgomery et al.   mBio

More Evidence of Collusion: a New Prophage-Mediated Viral Defense System Encoded by Mycobacteriophage Sbash

(2019) Gabrielle M. Gentile et al.   mBio

A mutant bacteriophage evolved to infect resistant bacteriagained a broader host range

(2019) Michal Habusha et al.   MOLECULAR MICROBIOLOGY

Deciphering the Molecular Mechanism Underpinning Phage Arbitrium Communication Systems

(2019) Francisca Gallego del Sol et al.   MOLECULAR CELL

Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla

(2019) Ruben V. Uribe et al.   Cell Host & Microbe

Marine DNA Viral Macro- and Microdiversity from Pole to Pole

(2019) Ann C. Gregory et al.   CELL

Widespread Utilization of Peptide Communication in Phages Infecting Soil and Pathogenic Bacteria

(2019) Avigail Stokar-Avihail et al.   Cell Host & Microbe

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

(2019) Gavin J. Knott et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An anti-CRISPR protein disables type V Cas12a by acetylation

(2019) Liyong Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Origins and evolution of CRISPR-Cas systems

(2019) Eugene V. Koonin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers

(2019) B. N. J. Watson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers

(2019) Justin E. Silpe et al.   mBio

Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage

(2019) Zeyuan Guan et al.   Cell Discovery

CRISPR–Cas in mobile genetic elements: counter-defence and beyond

(2019) Guilhem Faure et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease

(2019) Hannah N. Taylor et al.   RNA Biology

Three New Cs for CRISPR: Collateral, Communicate, Cooperate

(2019) Andrew Varble et al.   TRENDS IN GENETICS

Cyclic GMP–AMP signalling protects bacteria against viral infection

(2019) Daniel Cohen et al.   NATURE

Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein

(2019) Yuvaraj Bhoobalan-Chitty et al.   CELL

Cas9 Cleavage of Viral Genomes Primes the Acquisition of New Immunological Memories

(2019) Philip M. Nussenzweig et al.   Cell Host & Microbe

A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases

(2019) Senén D. Mendoza et al.   NATURE

A jumbo phage that forms a nucleus-like structure evades CRISPR–Cas DNA targeting but is vulnerable to type III RNA-based immunity

(2019) Lucia M. Malone et al.   Nature Microbiology

The Biology of CRISPR-Cas: Backward and Forward

(2018) Frank Hille et al.   CELL

Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity

(2018) Adair L. Borges et al.   CELL

Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity

(2018) Mariann Landsberger et al.   CELL

Immune loss as a driver of coexistence during host-phage coevolution

(2018) Jake L Weissman et al.   ISME Journal

Vibrio cholerae Outer Membrane Vesicles Inhibit Bacteriophage Infection

(2018) Tamara Reyes-Robles et al.   JOURNAL OF BACTERIOLOGY

Mycobacteriophage Fruitloop gp52 inactivates Wag31 (DivIVA) to prevent heterotypic superinfection

(2018) Ching-Chung Ko et al.   MOLECULAR MICROBIOLOGY

Destabilizing mutations encode nongenetic variation that drives evolutionary innovation

(2018) Katherine L. Petrie et al.   SCIENCE

Systematic discovery of antiphage defense systems in the microbial pangenome

(2018) Shany Doron et al.   SCIENCE

A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus

(2018) Can Chen et al.   Frontiers in Cellular and Infection Microbiology

Targeting mechanisms of tailed bacteriophages

(2018) Franklin L. Nobrega et al.   NATURE REVIEWS MICROBIOLOGY

Bioinformatic evidence of widespread priming in type I and II CRISPR-Cas systems

(2018) Thomas J. Nicholson et al.   RNA Biology

Enzymes and Mechanisms Employed by Tailed Bacteriophages to Breach the Bacterial Cell Barriers

(2018) Sofia Fernandes et al.   Viruses-Basel

A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision

(2018) Justin E. Silpe et al.   CELL

A chemical defence against phage infection

(2018) Sarah Kronheim et al.   NATURE

BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site

(2018) Julia Gordeeva et al.   NUCLEIC ACIDS RESEARCH

Structural and functional insights into the regulation of the lysis–lysogeny decision in viral communities

(2018) Chao Dou et al.   Nature Microbiology

Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum

(2018) Ahsen Özcan et al.   Nature Microbiology

Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute

(2017) Daan C. Swarts et al.   MOLECULAR CELL

The multicomponent antirestriction system of phage P1 is linked to capsid morphogenesis

(2017) Denish Piya et al.   MOLECULAR MICROBIOLOGY

Communication between viruses guides lysis–lysogeny decisions

(2017) Zohar Erez et al.   NATURE

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

Prokaryotic Argonaute proteins: novel genome-editing tools?

(2017) Jorrit W. Hegge et al.   NATURE REVIEWS MICROBIOLOGY

Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes

(2017) Marnix Vlot et al.   NUCLEIC ACIDS RESEARCH

CRISPR-Cas: Adapting to change

(2017) Simon A. Jackson et al.   SCIENCE

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

Assembly of a nucleus-like structure during viral replication in bacteria

(2017) Vorrapon Chaikeeratisak et al.   SCIENCE

Bacteria–Bacteriophage Coevolution in the Human Gut: Implications for Microbial Diversity and Functionality

(2017) Pauline D. Scanlan   TRENDS IN MICROBIOLOGY

Long-term genomic coevolution of host-parasite interaction in the natural environment

(2017) Elina Laanto et al.   Nature Communications

Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems

(2017) Sukrit Silas et al.   eLife

Guide-independent DNA cleavage by archaeal Argonaute from Methanocaldococcus jannaschii

(2017) Adrian Zander et al.   Nature Microbiology

Prophage-mediated defence against viral attack and viral counter-defence

(2017) Rebekah M. Dedrick et al.   Nature Microbiology

Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation

(2017) Hanjeong Harvey et al.   Nature Microbiology

DISARM is a widespread bacterial defence system with broad anti-phage activities

(2017) Gal Ofir et al.   Nature Microbiology

Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity

(2016) Wenyan Jiang et al.   CELL

A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages

(2016) Florence Depardieu et al.   Cell Host & Microbe

Prophages mediate defense against phage infection through diverse mechanisms

(2016) Joseph Bondy-Denomy et al.   ISME Journal

Evolutionary Ecology of Prokaryotic Immune Mechanisms

(2016) Stineke van Houte et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

(2016) Adrian G. Patterson et al.   MOLECULAR CELL

CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration

(2016) Jon McGinn et al.   MOLECULAR CELL

New CRISPR–Cas systems from uncultivated microbes

(2016) David Burstein et al.   NATURE

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

Quorum sensing controls thePseudomonas aeruginosaCRISPR-Cas adaptive immune system

(2016) Nina M. Høyland-Kroghsbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

(2015) Poulami Samai et al.   CELL

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense

(2015) Edze R. Westra et al.   CURRENT BIOLOGY

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

(2015) Sergey Shmakov et al.   MOLECULAR CELL

An ADP-ribosyltransferase Alt of bacteriophage T4 negatively regulates theEscherichia coli MazF toxin of a toxin-antitoxin module

(2015) Abdulraheem M. Alawneh et al.   MOLECULAR MICROBIOLOGY

The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity

(2015) Paul A. Hoskisson et al.   VIROLOGY

CRISPR Immunity Drives Rapid Phage Genome Evolution in Streptococcus thermophilus

(2015) David Paez-Espino et al.   mBio

BREX is a novel phage resistance system widespread in microbial genomes

(2014) T. Goldfarb et al.   EMBO JOURNAL

Systematic Identification of Hypothetical Bacteriophage Proteins Targeting Key Protein Complexes of Pseudomonas aeruginosa

(2014) An Van den Bossche et al.   JOURNAL OF PROTEOME RESEARCH

Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus

(2014) Gintautas Tamulaitis et al.   MOLECULAR CELL

Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

(2014) Gregory W. Goldberg et al.   NATURE

DNA-guided DNA interference by a prokaryotic Argonaute

(2014) Daan C. Swarts et al.   NATURE

CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages

(2014) Bruno Martel et al.   NUCLEIC ACIDS RESEARCH

A widespread bacteriophage abortive infection system functions through a Type IV toxin–antitoxin mechanism

(2014) Ron L. Dy et al.   NUCLEIC ACIDS RESEARCH

The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts

(2014) Pedro H. Oliveira et al.   NUCLEIC ACIDS RESEARCH

What Does the Talking?: Quorum Sensing Signalling Genes Discovered in a Bacteriophage Genome

(2014) Katherine R. Hargreaves et al.   PLoS One

Genomic Sequencing and Biological Characteristics of a Novel Escherichia Coli Bacteriophage 9g, a Putative Representative of a New Siphoviridae Genus

(2014) Eugene Kulikov et al.   Viruses-Basel

Abundant and Diverse Clustered Regularly Interspaced Short Palindromic Repeat Spacers in Clostridium difficile Strains and Prophages Target Multiple Phage Types within This Pathogen

(2014) K. R. Hargreaves et al.   mBio

Evolutionary consequences of intra-patient phage predation on microbial populations

(2014) Kimberley D Seed et al.   eLife

Remarkable Mechanisms in Microbes to Resist Phage Infections

(2014) Ron L. Dy et al.   Annual Review of Virology

Bacteriophage Orphan DNA Methyltransferases: Insights from Their Bacterial Origin, Function, and Occurrence

(2013) James Murphy et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Diverse Functions of Restriction-Modification Systems in Addition to Cellular Defense

(2013) K. Vasu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning

(2013) Hila Sberro et al.   MOLECULAR CELL

Bacterial Argonaute Samples the Transcriptome to Identify Foreign DNA

(2013) Ivan Olovnikov et al.   MOLECULAR CELL

A novel interference mechanism by a type IIIB CRISPR-Cmr module inSulfolobus

(2013) Ling Deng et al.   MOLECULAR MICROBIOLOGY

A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

(2013) Kimberley D. Seed et al.   NATURE

Revenge of the phages: defeating bacterial defences

(2013) Julie E. Samson et al.   NATURE REVIEWS MICROBIOLOGY

Highlights of the DNA cutters: a short history of the restriction enzymes

(2013) Wil A. M. Loenen et al.   NUCLEIC ACIDS RESEARCH

A Quorum-Sensing-Induced Bacteriophage Defense Mechanism

(2013) N. M. Hoyland-Kroghsbo et al.   mBio

Importance of prophages to evolution and virulence of bacterial pathogens

(2013) Louis-Charles Fortier et al.   Virulence

Virus-Host and CRISPR Dynamics in Archaea-Dominated Hypersaline Lake Tyrrell, Victoria, Australia

(2013) Joanne B. Emerson et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Metabolic reprogramming by viruses in the sunlit and dark ocean

(2013) Bonnie L Hurwitz et al.   GENOME BIOLOGY

Phage mutations in response to CRISPR diversification in a bacterial population

(2012) Christine L. Sun et al.   ENVIRONMENTAL MICROBIOLOGY

CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome

(2012) A. Stern et al.   GENOME RESEARCH

The CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages

(2012) K. C. Cady et al.   JOURNAL OF BACTERIOLOGY

A Multivalent Adsorption Apparatus Explains the Broad Host Range of Phage phi92: a Comprehensive Genomic and Structural Analysis

(2012) D. Schwarzer et al.   JOURNAL OF VIROLOGY

Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins

(2012) Yuichi Otsuka et al.   MOLECULAR MICROBIOLOGY

Structure and activity of AbiQ, a lactococcal endoribonuclease belonging to the type III toxin-antitoxin system

(2012) Julie E. Samson et al.   MOLECULAR MICROBIOLOGY

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system

(2012) Joe Bondy-Denomy et al.   NATURE

Mobile CRISPR/Cas-Mediated Bacteriophage Resistance in Lactococcus lactis

(2012) Anne M. Millen et al.   PLoS One

Repeatability and Contingency in the Evolution of a Key Innovation in Phage Lambda

(2012) J. R. Meyer et al.   SCIENCE

Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system

(2012) Kirill A. Datsenko et al.   Nature Communications

Viral Evasion of a Bacterial Suicide System by RNA–Based Molecular Mimicry Enables Infectious Altruism

(2012) Tim R. Blower et al.   PLoS Genetics

Contribution of bacterial outer membrane vesicles to innate bacterial defense

(2011) Andrew J Manning et al.   BMC MICROBIOLOGY

Co-evolution with lytic phage selects for the mucoid phenotype of Pseudomonas fluorescens SBW25

(2011) Pauline Deirdre Scanlan et al.   ISME Journal

Defense Islands in Bacterial and Archaeal Genomes and Prediction of Novel Defense Systems

(2011) K. S. Makarova et al.   JOURNAL OF BACTERIOLOGY

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

(2011) E. Semenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteria-Phage Antagonistic Coevolution in Soil

(2011) P. Gomez et al.   SCIENCE

Escherichia coli rnlA and rnlB Compose a Novel Toxin-Antitoxin System

(2010) M. Koga et al.   GENETICS

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair

(2009) Peter C. Fineran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

(2008) S. J. J. Brouns et al.   SCIENCE

Virus Population Dynamics and Acquired Virus Resistance in Natural Microbial Communities

(2008) A. F. Andersson et al.   SCIENCE