Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

Cardiolipin content is involved in liver mitochondrial energy wasting associated with cancer-induced cachexia without the involvement of adenine nucleotide translocase

(2014) Cloé Mimsy Julienne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease

(2014) Alfonso Eirin et al.   CARDIOVASCULAR RESEARCH

BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, NORMALIZES EXPRESSION OF CARDIOLIPIN REMODELING GENES AND PROTEINS IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

(2014) Hani N. Sabbah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

(2013) Michael P. Siegel et al.   AGING CELL

Rationale and design of the EMBRACE STEMI Study: A phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction

(2013) Anjan K. Chakrabarti et al.   AMERICAN HEART JOURNAL

Characterization of Acute and Chronic Neuropathies Induced by Oxaliplatin in Mice and Differential Effects of a Novel Mitochondria-targeted Antioxidant on the Neuropathies

(2013) Satoshi Toyama et al.   ANESTHESIOLOGY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

Mitochondrial Deficiency Is Associated With Insulin Resistance

(2013) B. H. Goodpaster   DIABETES

Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy

(2013) Valeria Righi et al.   FASEB JOURNAL

Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant

(2013) Erin E. Talbert et al.   JOURNAL OF APPLIED PHYSIOLOGY

A mitochondrial bioenergetic etiology of disease

(2013) Douglas C. Wallace   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension

(2013) Alfonso Eirin et al.   JOURNAL OF HYPERTENSION

LONG-TERM THERAPY WITH BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, REVERSES MITOCHONDRIAL FUNCTIONAL ABNORMALITIES IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

(2013) Hani N. Sabbah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Long-term therapy with Bendavia (MTP-131), a novel mitochondria-targeting peptide, normalizes functional mitochondrial abnormalities in left ventricular myocardium of dogs with heart failure

(2013) Hani N. Sabbah et al.   MITOCHONDRION

Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

(2013) Shao-Bin Duan et al.   RENAL FAILURE

Mitochondrial Dysfunction in Retinal Diseases

(2012) Megha Barot et al.   CURRENT EYE RESEARCH

Exercise efficiency is reduced by mitochondrial uncoupling in the elderly

(2012) Kevin E. Conley et al.   EXPERIMENTAL PHYSIOLOGY

A Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes After Revascularization in Experimental Atherosclerotic Renal Artery Stenosis

(2012) Alfonso Eirin et al.   HYPERTENSION

Cardiolipin-dependent Reconstitution of Respiratory Supercomplexes from PurifiedSaccharomyces cerevisiaeComplexes III and IV

(2012) Soledad Bazán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial permeability transition in the diabetic heart: Contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury

(2012) Ruben C. Sloan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondria in cardiac hypertrophy and heart failure

(2012) Mariana G. Rosca et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

(2012) Jing Ji et al.   NATURE NEUROSCIENCE

Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria‐Targeting Cytoprotective Peptide

(2012) Robert A. Kloner et al.   Journal of the American Heart Association

Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes

(2011) Laura A. A. Gilliam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impaired Mitochondrial Biogenesis Precedes Heart Failure in Right Ventricular Hypertrophy in Congenital Heart Disease

(2011) Georgios Karamanlidis et al.   Circulation-Heart Failure

Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness*

(2011) Scott K. Powers et al.   CRITICAL CARE MEDICINE

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy

(2011) Kisuk Min et al.   JOURNAL OF APPLIED PHYSIOLOGY

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

(2011) H. H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

Conformational properties of cardiolipin-bound cytochrome c

(2011) J. Hanske et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Mitochondria-Targeted Antioxidant Peptide Ameliorates Burn-Induced Apoptosis and Endoplasmic Reticulum Stress in the Skeletal Muscle of Mice

(2011) Hyung-yul Lee et al.   SHOCK

Toxicity of Neurons Treated with Herbicides and Neuroprotection by Mitochondria-Targeted Antioxidant SS31

(2011) Tejaswini P. Reddy et al.   International Journal of Environmental Research and Public Health

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

Mitochondria: An Emerging Target for Therapeutics

(2010) S P Hersh   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

(2009) Lichuan Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of cardiolipin in the structural organization of mitochondrial membranes

(2009) Michael Schlame et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Electron transfer in peptides and proteins

(2009) Meike Cordes et al.   CHEMICAL SOCIETY REVIEWS

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Human mitochondrial oxidative capacity is acutely impaired after burn trauma

(2008) Melanie G. Cree et al.   AMERICAN JOURNAL OF SURGERY

The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease

(2008) Kevin S. Eardley et al.   KIDNEY INTERNATIONAL

Mitochondrial dysfunction in rat brain with agingInvolvement of complex I, reactive oxygen species and cardiolipin

(2008) G PETROSILLO et al.   NEUROCHEMISTRY INTERNATIONAL