Protective potential of hydroxysafflor yellow A in cerebral ischemia and reperfusion injury: An overview of evidence from experimental studies

Hydroxysafflor Yellow A Blocks HIF-1α Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium

(2022) Yi Li et al.   Antioxidants

Hydroxysafflor yellow A alleviates cerebral ischemia reperfusion injury by suppressing apoptosis via mitochondrial permeability transition pore

(2021) Ping Huang et al.   PHYTOMEDICINE

Dysregulated autophagy is linked to BAX oligomerization and subsequent cytochrome c release in 6-hydroxydopmaine-treated neuronal cells

(2021) Yuhyun Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthetic Biology towards Improved Flavonoid Pharmacokinetics

(2021) Moon Sajid et al.   Biomolecules

Sevoflurane preconditioning protects experimental ischemic stroke by enhancing anti‐inflammatory microglia/macrophages phenotype polarization through GSK‐3β/Nrf2 pathway

(2021) Min Cai et al.   CNS Neuroscience & Therapeutics

Hydroxysafflor yellow A and anhydrosafflor yellow B alleviate ferroptosis and parthanatos in PC12 cells injured by OGD/R

(2021) Guangwei Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis

(2021) Xinyan Xue et al.   PHYTOMEDICINE

Hydroxysafflor Yellow A and Anhydrosafflor Yellow B Protect Against Cerebral Ischemia/Reperfusion Injury by Attenuating Oxidative Stress and Apoptosis via the Silent Information Regulator 1 Signaling Pathway

(2021) Yijia Fangma et al.   Frontiers in Pharmacology

Hydroxysafflor Yellow A Confers Neuroprotection from Focal Cerebral Ischemia by Modulating the Crosstalk Between JAK2/STAT3 and SOCS3 Signaling Pathways

(2020) Lu Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway

(2020) Dequan Liu et al.   Drug Design Development and Therapy

Effect and Safety of Hydroxysafflor Yellow A for Injection in Patients with Acute Ischemic Stroke of Blood Stasis Syndrome: A Phase II, Multicenter, Randomized, Double-Blind, Multiple-Dose, Active-Controlled Clinical Trial

(2020) Ming-zhe Hu et al.   Chinese Journal of Integrative Medicine

Sodium butyrate attenuated neuronal apoptosis via GPR41/Gβγ/PI3K/Akt pathway after MCAO in rats

(2020) Zhenhua Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Association between lipoprotein(a) concentration and the risk of stroke in the Chinese Han population: a retrospective case-control study

(2020) Hanhui Fu et al.   Annals of Translational Medicine

Integrated metabolomics and transcriptome analysis on flavonoid biosynthesis in safflower (Carthamus tinctorius L.) under MeJA treatment

(2020) Jiang Chen et al.   BMC PLANT BIOLOGY

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia

(2020) Zelin Lai et al.   Cell and Bioscience

Investigation of Invigorating Qi and Activating Blood Circulation Prescriptions in Treating Qi Deficiency and Blood Stasis Syndrome of Ischemic Stroke Patients: Study Protocol for a Randomized Controlled Trial

(2020) Yu Wang et al.   Frontiers in Pharmacology

Hydroxysafflor Yellow A Together with Blood–Brain Barrier Regulator Lexiscan for Cerebral Ischemia Reperfusion Injury Treatment

(2020) Liwei Tan et al.   ACS Omega

Astrocyte Crosstalk in CNS Inflammation

(2020) Mathias Linnerbauer et al.   NEURON

Protective effect of Hydroxysafflor Yellow A on cerebral ischemia reperfusion-injury by regulating GSK3β-mediated pathways

(2020) Xiaomei Yang et al.   NEUROSCIENCE LETTERS

The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

(2020) Maximilian Franke et al.   BRAIN BEHAVIOR AND IMMUNITY

Astragaloside and/or Hydroxysafflor Yellow A Attenuates Oxygen-Glucose Deprivation-Induced Cultured Brain Microvessel Endothelial Cell Death through Downregulation of PHLPP-1

(2020) Jinyi Cao et al.   Evidence-based Complementary and Alternative Medicine

Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects

(2020) Feng Zhao et al.   Frontiers in Pharmacology

Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia/reperfusion injury via metabolic inhibition of phenylalanine and mitochondrial biogenesis

(2019) Suning Chen et al.   Molecular Medicine Reports

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

(2019) Henry Ma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: Involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway

(2018) Guang Yang et al.   BRAIN RESEARCH BULLETIN

Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using 18 F-fuorodeoxyglucose

(2018) Ling Deng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective cerebrovascular effects of hydroxysafflor yellow A (HSYA) on ischemic stroke

(2018) Yang Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MicroRNA‑634 alters nerve apoptosis via the PI3K/Akt pathway in cerebral infarction

(2018) Yajun Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Solid lipid nanoparticles as carriers for oral delivery of hydroxysafflor yellow A

(2018) Bingxiang Zhao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The potential mechanism for Hydroxysafflor yellow A attenuating blood-brain barrier dysfunction via tight junction signaling pathways excavated by an integrated serial affinity chromatography and shotgun proteomics analysis approach

(2018) Yanni Lv et al.   NEUROCHEMISTRY INTERNATIONAL

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Global Burden of Stroke

(2018) Mira Katan et al.   SEMINARS IN NEUROLOGY

Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1

(2018) Jinkun Wang et al.   Scientific Reports

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

The Overlooked Aspect of Excitotoxicity: Glutamate‐Independent Excitotoxicity in Traumatic Brain Injuries

(2018) Joel Tehse et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke

(2018) Qianyi Huang et al.   Journal of Neuroinflammation

Hydroxysafflor Yellow A (HSYA) Improves Learning and Memory in Cerebral Ischemia Reperfusion-Injured Rats via Recovering Synaptic Plasticity in the Hippocampus

(2018) Lu Yu et al.   Frontiers in Cellular Neuroscience

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies

(2018) Weijie Xie et al.   Cells

NDRG4 protects against cerebral ischemia injury by inhibiting p53-mediated apoptosis

(2018) Lan Wen et al.   BRAIN RESEARCH BULLETIN

Synergistic neuroprotective effects of Danshensu and hydroxysafflor yellow A on cerebral ischemia-reperfusion injury in rats

(2017) Hang Xu et al.   Oncotarget

Phytochemistry and Pharmacology of Carthamus tinctorius L.

(2016) Le-Le Zhang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs

(2016) Xingtao Wang et al.   ASN Neuro

Hydroxysafflor Yellow A Attenuates Neuron Damage by Suppressing the Lipopolysaccharide-Induced TLR4 Pathway in Activated Microglial Cells

(2016) Yanni Lv et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke

(2016) Han-Sen Chen et al.   Current Neuropharmacology

Corrigendum to “The Value of Safflower Yellow Injection for the Treatment of Acute Cerebral Infarction: A Randomized Controlled Trial”

(2016) Le-Jun Li et al.   Evidence-based Complementary and Alternative Medicine

Hydroxysafflor yellow A exerts neuroprotective effects in cerebral ischemia reperfusion-injured mice by suppressing the innate immune TLR4-inducing pathway

(2015) Yanni Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acute Stroke Intervention

(2015) Shyam Prabhakaran et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacokinetic profiles of hydroxysafflor yellow A following intravenous administration of its pure preparations in healthy Chinese volunteers

(2015) Chang-Yin Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Inhibition of Autophagy via Activation of PI3K/Akt Pathway Contributes to the Protection of Ginsenoside Rb1 against Neuronal Death Caused by Ischemic Insults

(2014) Tianfei Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Huangqi−Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats

(2014) Jinyi Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats

(2014) Ren-ai Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Herbal Medicines for Ischemic Stroke: Combating Inflammation as Therapeutic Targets

(2014) Yong Gu et al.   Journal of Neuroimmune Pharmacology

Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats

(2014) Lin Chen et al.   NEUROCHEMISTRY INTERNATIONAL

AKT-Related Autophagy Contributes to the Neuroprotective Efficacy of Hydroxysafflor Yellow A against Ischemic Stroke in Rats

(2014) Zhifeng Qi et al.   Translational Stroke Research

Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway

(2013) Peng-Ran Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

NMR Solution Structure Study of the Representative Component Hydroxysafflor Yellow A and Other Quinochalcone C-Glycosides from Carthamus tinctorius

(2013) Zi-Ming Feng et al.   JOURNAL OF NATURAL PRODUCTS

Chemical and Biological Properties of Quinochalcone C-Glycosides from the Florets of Carthamus tinctorius

(2013) Shijun Yue et al.   MOLECULES

Hydroxysafflor Yellow A Protects Against Cerebral Ischemia–Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat

(2013) Lin Chen et al.   NEUROCHEMICAL RESEARCH

Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen–glucose deprivation

(2013) Jie Li et al.   NEUROSCIENCE LETTERS

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: Inhibition of protein oxidation/nitration, 12/15-lipoxygenase and blood–brain barrier disruption

(2012) Li Sun et al.   BRAIN RESEARCH

Enhanced absorption of hydroxysafflor yellow A using a self-double-emulsifying drug delivery system: in vitro and in vivo studies

(2012) Min Han et al.   International Journal of Nanomedicine

PHLPP1 Gene Deletion Protects the Brain from Ischemic Injury

(2012) Bo Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

l-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia

(2012) Jing Xu et al.   NEUROPHARMACOLOGY

Hydroxysafflor Yellow A Protects PC12 Cells Against the Apoptosis Induced by Oxygen and Glucose Deprivation

(2011) Lihong Fan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Predictors for Poststroke Outcomes: The Tel Aviv Brain Acute Stroke Cohort (TABASCO) Study Protocol

(2011) Einor Ben Assayag et al.   International Journal of Stroke

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

Novel Phosphatase PHLPP-1 Regulates Mitochondrial Akt Activity and Cardiac Cell Survival

(2010) Yaron Aviv et al.   CIRCULATION RESEARCH

Clinical Pharmacokinetics of Tonapofylline: Evaluation of Dose Proportionality, Oral Bioavailability, and Gender and Food Effects in Healthy Human Subjects

(2010) Zhaoyang Li et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Neuroprotective Effects of Hydroxysafflor Yellow A Against Excitotoxic Neuronal Death Partially Through Down-Regulation of NR2B-Containing NMDA Receptors

(2010) Q. Yang et al.   NEUROCHEMICAL RESEARCH

Autophagy in disease: a double-edged sword with therapeutic potential

(2009) Wim Martinet et al.   CLINICAL SCIENCE

Hydroxysafflor yellow a protects neuron against hypoxia injury and suppresses inflammatory responses following focal ischemia reperfusion in rats

(2008) Sheng-Ying Ye et al.   ARCHIVES OF PHARMACAL RESEARCH

Hydroxysafflor Yellow A Inhibits Rat Brain Mitochondrial Permeability Transition Pores by a Free Radical Scavenging Action

(2008) Jingwei Tian et al.   PHARMACOLOGY