Synthetic Biology towards Improved Flavonoid Pharmacokinetics

Engineering new catalytic activities in enzymes

(2020) Kai Chen et al.   Nature Catalysis

Advances on the in vivo and in vitro glycosylations of flavonoids

(2020) Yuan Ji et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

In vitro prototyping and rapid optimization of biosynthetic enzymes for cell design

(2020) Ashty S. Karim et al.   Nature Chemical Biology

Cell-Free Synthetic Glycobiology: Designing and Engineering Glycomolecules Outside of Living Cells

(2020) Thapakorn Jaroentomeechai et al.   Frontiers in Chemistry

Metabolically engineering of Yarrowia lipolytica for the biosynthesis of naringenin from a mixture of glucose and xylose

(2020) Wenping Wei et al.   BIORESOURCE TECHNOLOGY

Modeling regulatory networks using machine learning for systems metabolic engineering

(2020) Mun Su Kwon et al.   CURRENT OPINION IN BIOTECHNOLOGY

Can enzyme proximity accelerate cascade reactions?

(2019) Andrij Kuzmak et al.   Scientific Reports

Cell-free gene-regulatory network engineering with synthetic transcription factors

(2019) Zoe Swank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DeepRibo: a neural network for precise gene annotation of prokaryotes by combining ribosome profiling signal and binding site patterns

(2019) Jim Clauwaert et al.   NUCLEIC ACIDS RESEARCH

In vitro Naringenin Biosynthesis from p-Coumaric Acid Using Recombinant Enzymes

(2019) Ying Zang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolic Engineering of Saccharomyces cerevisiae for De Novo Production of Kaempferol

(2019) Xiaomei Lyu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Light-based control of metabolic flux through assembly of synthetic organelles

(2019) Evan M. Zhao et al.   Nature Chemical Biology

Machine learning-assisted directed protein evolution with combinatorial libraries

(2019) Zachary Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo

(2019) Jiale Qu et al.   ACS Nano

Deep learning enables high-quality and high-throughput prediction of enzyme commission numbers

(2019) Jae Yong Ryu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic biology strategies for microbial biosynthesis of plant natural products

(2019) Aaron Cravens et al.   Nature Communications

Machine and deep learning meet genome-scale metabolic modeling

(2019) Guido Zampieri et al.   PLoS Computational Biology

Potential Anticancer Properties and Mechanisms of Action of Formononetin

(2019) Dongjun Jiang et al.   Biomed Research International

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

(2019) Qingmei Ye et al.   Frontiers in Oncology

Predicting gene regulatory interactions based on spatial gene expression data and deep learning

(2019) Yang Yang et al.   PLoS Computational Biology

Optimizing Oleaginous Yeast Cell Factories for Flavonoids and Hydroxylated Flavonoids Biosynthesis

(2019) Yongkun Lv et al.   ACS Synthetic Biology

High-Throughput Synthesis and Analysis of Intact Glycoproteins Using SAMDI-MS

(2019) José-Marc Techner et al.   ANALYTICAL CHEMISTRY

Deep learning for inferring gene relationships from single-cell expression data

(2019) Ye Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship

(2019) Xiaoqing Fan et al.   TOXICOLOGY IN VITRO

Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases

(2018) Weston Kightlinger et al.   Nature Chemical Biology

The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

(2018) Lee J. Sweetlove et al.   Nature Communications

Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form: a randomized, double-blind, crossover study

(2018) Corinna E Rüfer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Inferring gene expression networks with hubs using a degree weighted Lasso approach

(2018) Nurgazy Sulaimanov et al.   BIOINFORMATICS

Artificial Protein Scaffold System ( AProSS ): An efficient method to optimize exogenous metabolic pathways in Saccharomyces cerevisiae

(2018) Tianyi Li et al.   METABOLIC ENGINEERING

Regulation of ATP levels in Escherichia coli using CRISPR interference for enhanced pinocembrin production

(2018) Sha Tao et al.   Microbial Cell Factories

Planning chemical syntheses with deep neural networks and symbolic AI

(2018) Marwin H. S. Segler et al.   NATURE

New insights on bioactivities and biosynthesis of flavonoid glycosides

(2018) Bao Yang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering

(2018) Seyed Mohammad Nabavi et al.   BIOTECHNOLOGY ADVANCES

Expanding biological applications using cell-free metabolic engineering: An overview

(2018) James R. Swartz   METABOLIC ENGINEERING

De novo biosynthesis of myricetin, kaempferol and quercetin in Streptomyces albus and Streptomyces coelicolor

(2018) Laura Marín et al.   PLoS One

Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine

(2018) Jianhua Li et al.   METABOLIC ENGINEERING

Microbial cell factories for the sustainable manufacturing of B vitamins

(2018) Carlos G Acevedo-Rocha et al.   CURRENT OPINION IN BIOTECHNOLOGY

Production of naringenin from D-xylose with co-culture of E. coli and S. cerevisiae

(2017) Wei Zhang et al.   ENGINEERING IN LIFE SCIENCES

Exploiting the aglycon promiscuity of glycosyltransferase Bs-YjiC from Bacillus subtilis and its application in synthesis of glycosides

(2017) Longhai Dai et al.   JOURNAL OF BIOTECHNOLOGY

Spatial organization of multi-enzyme biocatalytic cascades

(2017) M. B. Quin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity

(2017) Raj Chari et al.   ACS Synthetic Biology

De Novo Biosynthesis of Apigenin, Luteolin, and Eriodictyol in the Actinomycete Streptomyces albus and Production Improvement by Feeding and Spore Conditioning

(2017) Laura Marín et al.   Frontiers in Microbiology

Recent developments in the enzymatic O-glycosylation of flavonoids

(2016) Bernd Hofer   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Flavonoids as Potent Scavengers of Hydroxyl Radicals

(2016) Jakub Treml et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Methylation of flavonoids: Chemical structures, bioactivities, progress and perspectives for biotechnological production

(2016) Niranjan Koirala et al.   ENZYME AND MICROBIAL TECHNOLOGY

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review

(2016) Weiyou Wang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Flavan-3-ols consumption and cancer risk: a meta-analysis of epidemiologic studies

(2016) Lei Lei et al.   Oncotarget

In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis

(2016) Anthony W. Goering et al.   ACS Synthetic Biology

Engineering of Secondary Metabolism

(2015) Sarah E. O'Connor   Annual Review of Genetics

Computational protein design enables a novel one-carbon assimilation pathway

(2015) Justin B. Siegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and characterisation of flavonoids from the leaves of medicinal plant Orthosiphon stamineus

(2015) M. Amzad Hossain et al.   Arabian Journal of Chemistry

Advances in the biotechnological glycosylation of valuable flavonoids

(2014) Jianbo Xiao et al.   BIOTECHNOLOGY ADVANCES

Assessing acceptor substrate promiscuity of YjiC-mediated glycosylation toward flavonoids

(2014) Ramesh Prasad Pandey et al.   CARBOHYDRATE RESEARCH

Glycosylation and subsequent malonylation of isoflavonoids in E. coli: strain development, production and insights into future metabolic perspectives

(2014) Niranjan Koirala et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Synthesis and Accumulation of Aromatic Aldehydes in an Engineered Strain of Escherichia coli

(2014) Aditya M. Kunjapur et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Hepatic, gastric, and intestinal first-pass effects of vitexin in rats

(2014) He-Fei Xue et al.   PHARMACEUTICAL BIOLOGY

Modular Optimization of Heterologous Pathways for De Novo Synthesis of (2S)-Naringenin in Escherichia coli

(2014) Junjun Wu et al.   PLoS One

Glycosylation Reactions in the Synthesis of Flavonoid Glycosides

(2014) Biao Yu et al.   SYNTHESIS-STUTTGART

Chemopreventive effect of flavonoids from Ougan (Citrus reticulata cv. Suavissima) fruit against cancer cell proliferation and migration

(2014) Jiukai Zhang et al.   Journal of Functional Foods

Structure and mechanism of a nonhaem-iron SAM-dependentC-methyltransferase and its engineering to a hydratase and anO-methyltransferase

(2014) Xiao-Wei Zou et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

N-linked protein glycosylation in the ER

(2013) Markus Aebi   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bioavailability of Quercetin: Problems and Promises

(2013) X. Cai et al.   CURRENT MEDICINAL CHEMISTRY

Novel fermentation processes for manufacturing plant natural products

(2013) Jingwen Zhou et al.   CURRENT OPINION IN BIOTECHNOLOGY

Assessing the Regioselectivity of OleD-Catalyzed Glycosylation with a Diverse Set of Acceptors

(2013) Maoquan Zhou et al.   JOURNAL OF NATURAL PRODUCTS

Preparative Isolation and Purification of Five Flavonoid Glycosides and One Benzophenone Galloyl Glycoside from Psidium guajava by High-Speed Counter-Current Chromatography (HSCCC)

(2013) Yindi Zhu et al.   MOLECULES

Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis

(2013) R. W. Gantt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro inhibition of canine distemper virus by flavonoids and phenolic acids: Implications of structural differences for antiviral design

(2013) O.V. Carvalho et al.   RESEARCH IN VETERINARY SCIENCE

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

Absolute bioavailability, pharmacokinetics and excretion of 5,7,3′,4′-tetramethoxyflavone in rats

(2013) Guor-Jien Wei et al.   Journal of Functional Foods

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Catalysts

(2012) Tom Desmet et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats

(2012) Chung-Ping Yu et al.   Evidence-based Complementary and Alternative Medicine

Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells

(2012) Somchaiya Surichan et al.   FOOD AND CHEMICAL TOXICOLOGY

De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae

(2012) Frank Koopman et al.   Microbial Cell Factories

Which Sources of Flavonoids: Complex Diets or Dietary Supplements?

(2012) Sarah Egert et al.   Advances in Nutrition

Flavonoids: biosynthesis, biological functions, and biotechnological applications

(2012) María L. Falcone Ferreyra et al.   Frontiers in Plant Science

Recent Progress in the Synthesis of Flavonoids: From Monomers to Supra-Complex Molecules

(2011) Kin-ichi Oyama et al.   CURRENT ORGANIC CHEMISTRY

Flavanones and rotenoids from the roots of Amorpha fruticosa L. that inhibit bacterial neuraminidase

(2011) Young Soo Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Cell-Free Expression and Assembly of ATP Synthase

(2011) Doreen Matthies et al.   JOURNAL OF MOLECULAR BIOLOGY

Leishmania cell-free protein expression system

(2011) Oleksiy Kovtun et al.   METHODS

Effect of Different Light Intensities on Total Phenolics and Flavonoids Synthesis and Anti-oxidant Activities in Young Ginger Varieties (Zingiber officinale Roscoe)

(2010) Ali Ghasemzadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacokinetics ofTrans-resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects

(2009) Teresa Nunes et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Kinetic solubility and dissolution velocity of rutin nanocrystals

(2008) Rachmat Mauludin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Flavonoid intake and ovarian cancer risk in a population-based case-control study

(2008) Margaret A. Gates et al.   INTERNATIONAL JOURNAL OF CANCER

Effects of Various Temperatures and pH Values on the Extraction Yield of Phenolics from Litchi Fruit Pericarp Tissue and the Antioxidant Activity of the Extracted Anthocyanins

(2008) Neungnapa Ruenroengklin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of nutrient mixture and black grapes on the pharmacokinetics of orally administered (-)epigallocatechin-3-gallate from green tea extract: a human study

(2008) Sonia Gawande et al.   PHYTOTHERAPY RESEARCH