Hydroxysafflor yellow A alleviates cerebral ischemia reperfusion injury by suppressing apoptosis via mitochondrial permeability transition pore

Hydroxysafflor Yellow A Confers Neuroprotection from Focal Cerebral Ischemia by Modulating the Crosstalk Between JAK2/STAT3 and SOCS3 Signaling Pathways

(2020) Lu Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Effect and Safety of Hydroxysafflor Yellow A for Injection in Patients with Acute Ischemic Stroke of Blood Stasis Syndrome: A Phase II, Multicenter, Randomized, Double-Blind, Multiple-Dose, Active-Controlled Clinical Trial

(2020) Ming-zhe Hu et al.   Chinese Journal of Integrative Medicine

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK/p38 signaling pathways

(2020) Bin He et al.   Reproductive Biology and Endocrinology

Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism

(2020) Luciana Isaja et al.   Scientific Reports

Proteomic Analysis of Hydroxysafflor Yellow A Against Cerebral Ischemia/Reperfusion Injury in Rats

(2019) Hang Xu et al.   REJUVENATION RESEARCH

Ligustilide ameliorates the permeability of the blood-brain barrier model in vitro during oxygen-glucose deprivation injury through HIF/VEGF pathway

(2019) Sipeng Wu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model

(2019) Sylvia J. Wowro et al.   Frontiers in Cellular Neuroscience

Uncovering the pharmacological mechanism of Carthamus tinctorius L. on cardiovascular disease by a systems pharmacology approach

(2019) Guohua Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

A small molecule protects mitochondrial integrity by inhibiting mTOR activity

(2019) Ran Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylene Blue Reduces Neuronal Apoptosis and Improves Blood-Brain Barrier Integrity After Traumatic Brain Injury

(2019) Jun Shen et al.   Frontiers in Neurology

Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: Involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway

(2018) Guang Yang et al.   BRAIN RESEARCH BULLETIN

Hydroxysafflor Yellow A Reprograms TLR9 Signalling Pathway in Ischaemic Cortex after Cerebral Ischaemia and Reperfusion

(2018) Zhe Gong et al.   CNS & Neurological Disorders-Drug Targets

Epidemiology report: trends in sex-specific cerebrovascular disease mortality in Europe based on WHO mortality data

(2018) Rushabh Shah et al.   EUROPEAN HEART JOURNAL

Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA

(2018) Dongjian Hu et al.   CIRCULATION RESEARCH

YiQi Tongluo Granule against Cerebral Ischemia/Reperfusion Injury in Rats by Freezing GluN2B and CaMK II through NMDAR/ERK1/2 Signaling

(2018) Si-peng Wu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke

(2016) Han-Sen Chen et al.   Current Neuropharmacology

Compartment-specific Control of Reactive Oxygen Species Scavenging by Antioxidant Pathway Enzymes

(2016) Swati Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Look into brain energy crisis and membrane pathophysiology in ischemia and reperfusion

(2016) Maria Chomova et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

U0126 Attenuates Cerebral Vasoconstriction and Improves Long-Term Neurologic Outcome after Stroke in Female Rats

(2015) Hilda Ahnstedt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

(2014) Lee J. Martin et al.   Frontiers in Cellular Neuroscience

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

(2013) Sally Martin et al.   PLoS One

Pipoxolan Ameliorates Cerebral Ischemia via Inhibition of Neuronal Apoptosis and Intimal Hyperplasia through Attenuation of VSMC Migration and Modulation of Matrix Metalloproteinase-2/9 and Ras/MEK/ERK Signaling Pathways

(2013) Yuh-Fung Chen et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Pre- and Post-treatment with Cyclosporine a in a Rat Model of Transient Focal Cerebral Ischaemia with Multimodal MRI Screening

(2012) Tae-Hee Cho et al.   International Journal of Stroke

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

(2012) Joanna M Wardlaw et al.   LANCET

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Mitochondria as Chi: Figure 1.—

(2008) Douglas C. Wallace   GENETICS