Why does understanding the biology of fibroblasts in immunity really matter?

Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts

(2022) Dimitra Kerdidani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils direct preexisting matrix to initiate repair in damaged tissues

(2022) Adrian Fischer et al.   NATURE IMMUNOLOGY

Multitier mechanics control stromal adaptations in the swelling lymph node

(2022) Frank P. Assen et al.   NATURE IMMUNOLOGY

Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions

(2022) Noriko Komatsu et al.   Nature Reviews Rheumatology

Microenvironmental sensing by fibroblasts controls macrophage population size

(2022) Xu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tertiary Lymphoid Structures as Mediators of Immunotherapy Response

(2022) Raj G. Vaghjiani et al.   Cancers

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

(2021) Jasna Friščić et al.   IMMUNITY

A molecular single-cell lung atlas of lethal COVID-19

(2021) Johannes C. Melms et al.   NATURE

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

(2021) Allon Wagner et al.   CELL

Importance of lymphocyte–stromal cell interactions in autoimmune and inflammatory rheumatic diseases

(2021) Mélissa Noack et al.   Nature Reviews Rheumatology

Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks

(2021) Sophie E. Acton et al.   TRENDS IN IMMUNOLOGY

Lymph node fibroblastic reticular cells steer immune responses

(2021) Lushen Li et al.   TRENDS IN IMMUNOLOGY

Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies

(2021) Wendi Kang et al.   Frontiers in Immunology

Anatomically distinct fibroblast subsets determine skin autoimmune patterns

(2021) Zijian Xu et al.   NATURE

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

The role of fibroblast activation protein in health and malignancy

(2020) Allison A. Fitzgerald et al.   CANCER AND METASTASIS REVIEWS

Dual function of perivascular fibroblasts in vascular stabilization in zebrafish

(2020) Arsheen M. Rajan et al.   PLoS Genetics

Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis

(2020) Michael David Brügger et al.   PLOS BIOLOGY

Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth

(2019) Olga N. Karpus et al.   Cell Reports

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

(2019) Matthias Friedrich et al.   IMMUNITY

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

(2019) Saba Nayar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

(2018) Ju Hun Yeon et al.   Acta Biomaterialia

Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease

(2018) Holm H. Uhlig et al.   Annual Review of Immunology

Podoplanin: An emerging cancer biomarker and therapeutic target

(2018) Harini Krishnan et al.   CANCER SCIENCE

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Macrophages in inflammation, repair and regeneration

(2018) Yumiko Oishi et al.   INTERNATIONAL IMMUNOLOGY

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

(2018) Joern Pezoldt et al.   Nature Communications

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

(2018) Yael Raz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators

(2017) Hung N. Nguyen et al.   IMMUNITY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Current and emerging therapeutic targets for IBD

(2017) Markus F. Neurath   Nature Reviews Gastroenterology & Hepatology

Tumor-associated fibroblasts predominantly come from local and not circulating precursors

(2016) Ainhoa Arina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

(2014) Jillian L Astarita et al.   NATURE IMMUNOLOGY

Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer

(2013) L. Bochet et al.   CANCER RESEARCH

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target

(2013) L. S. Verjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses

(2012) Tangsheng Yi et al.   IMMUNITY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Extracellular matrix mechanics in lung parenchymal diseases

(2008) Béla Suki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY