Lymph node fibroblastic reticular cells steer immune responses

Development and Immunological Function of Lymph Node Stromal Cells

(2021) Natalia Barbara Pikor et al.   JOURNAL OF IMMUNOLOGY

Remodeling of the Lymph Node High Endothelial Venules Reflects Tumor Invasiveness in Breast Cancer and is Associated with Dysregulation of Perivascular Stromal Cells

(2021) Tove Bekkhus et al.   Cancers

NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis

(2021) Carlo De Salvo et al.   JOURNAL OF CLINICAL INVESTIGATION

Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

(2021) Varun N. Kapoor et al.   NATURE IMMUNOLOGY

IL‐7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival

(2020) Laura Knop et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The lymph node stromal laminin α5 shapes alloimmunity

(2020) Lushen Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymph node stromal cells: cartographers of the immune system

(2020) Akshay T. Krishnamurty et al.   NATURE IMMUNOLOGY

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

(2020) Natalia B. Pikor et al.   NATURE IMMUNOLOGY

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

(2020) Reza Nadafi et al.   Cell Reports

Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization

(2020) Jeffrey Lian et al.   Cell Reports

Lymph node stromal CCL2 limits antibody responses

(2020) Dragos C. Dasoveanu et al.   Science Immunology

Periarteriolar stroma cells guide T cells from the red to the white pulp in the spleen

(2020) Chang H. Kim et al.   Cellular & Molecular Immunology

Stromal cell control of conventional and ectopic germinal centre reactions

(2020) Alyssa Silva-Cayetano et al.   CURRENT OPINION IN IMMUNOLOGY

The fibroblastic T cell niche in lymphoid tissues

(2020) Anne L Fletcher et al.   CURRENT OPINION IN IMMUNOLOGY

Fibroblast‐derived IL‐33 is dispensable for lymph node homeostasis but critical for CD8 T‐cell responses to acute and chronic viral infection

(2020) Patricia Aparicio‐Domingo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

(2020) Jason Cosgrove et al.   Nature Communications

Shattering barriers toward clinically meaningful MSC therapies

(2020) Oren Levy et al.   Science Advances

IL-33/ST2 signaling in liver transplantation

(2020) Zhongming Tan et al.   Cellular & Molecular Immunology

Fibroblasts as a source of self-antigens for central immune tolerance

(2020) Takeshi Nitta et al.   NATURE IMMUNOLOGY

IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

(2020) Rania Dagher et al.   Nature Communications

Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells

(2020) Christian Perez-Shibayama et al.   Science Immunology

Fibroblastic reticular cells at the nexus of innate and adaptive immune responses

(2019) Christian Perez‐Shibayama et al.   IMMUNOLOGICAL REVIEWS

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival

(2019) Saikat Majumder et al.   NATURE IMMUNOLOGY

IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

(2019) Lalit Kumar Dubey et al.   Cell Reports

Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche

(2019) Abdouramane Camara et al.   IMMUNITY

Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Regulation of T Cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node

(2019) Thomas Simon et al.   TRANSPLANTATION

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

(2019) Raul German Spallanzani et al.   Science Immunology

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils

(2019) Akira Takeda et al.   IMMUNITY

Role of lymph node stroma and microenvironment in T cell tolerance

(2019) Vikas Saxena et al.   IMMUNOLOGICAL REVIEWS

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

(2019) Flavian D. Brown et al.   NATURE IMMUNOLOGY

Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion

(2019) Victor G. Martinez et al.   Cell Reports

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

(2018) Yang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

(2018) Hsin-Ying Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A short field guide to fibroblast function in immunity

(2018) Matthew B. Buechler et al.   SEMINARS IN IMMUNOLOGY

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

(2018) Konstantin Knoblich et al.   PLOS BIOLOGY

The conduit system exports locally secreted IgM from lymph nodes

(2018) Guilhem R. Thierry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node

(2018) Arata Takeuchi et al.   Frontiers in Immunology

Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis

(2018) Vivek Kasinath et al.   KIDNEY INTERNATIONAL

Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses

(2017) Abhishek Das et al.   IMMUNITY

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

(2017) Jooho Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D)

(2017) Weizhe Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

(2017) Lalit Kumar Dubey et al.   Nature Communications

Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

(2017) Julia L. Gregory et al.   Cell Reports

Tumor-induced stromal reprogramming drives lymph node transformation

(2016) Angela Riedel et al.   NATURE IMMUNOLOGY

Innate lymphoid cells in defense, immunopathology and immunotherapy

(2016) Sascha Cording et al.   NATURE IMMUNOLOGY

IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

(2016) Michael Peine et al.   TRENDS IN IMMUNOLOGY

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

(2016) Lalit Kumar Dubey et al.   Cell Reports

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

(2015) Denise Morais da Fonseca et al.   CELL

A Dendritic-Cell-Stromal Axis Maintains Immune Responses in Lymph Nodes

(2015) Varsha Kumar et al.   IMMUNITY

A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells

(2015) Kerim Hoorweg et al.   JOURNAL OF IMMUNOLOGY

Fibroblastic Reticular Cells: Organization and Regulation of the T Lymphocyte Life Cycle

(2015) Flavian D. Brown et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and Morphological Properties of Germinal Center Dark ZoneCxcl12-Expressing Reticular Cells

(2015) Lauren B. Rodda et al.   JOURNAL OF IMMUNOLOGY

Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance

(2015) Bryna E. Burrell et al.   TRANSPLANTATION

Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L

(2015) Yumi Nakayama et al.   TRANSPLANTATION

Laminins affect T cell trafficking and allograft fate

(2014) Kristi J. Warren et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Lymph Node Fibroblastic Reticular Cells and High Endothelial Cells Is Associated with Humoral Immunodeficiency in Mouse Graft-versus-Host Disease

(2014) Fumiko Suenaga et al.   JOURNAL OF IMMUNOLOGY

The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

(2014) Jillian L Astarita et al.   NATURE IMMUNOLOGY

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

(2014) Viviana Cremasco et al.   NATURE IMMUNOLOGY

Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis

(2014) A. L. Fletcher et al.   Science Translational Medicine

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

(2014) Antonio P Baptista et al.   eLife

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

AID-Expressing Germinal Center B Cells Cluster Normally within Lymph Node Follicles in the Absence of FDC-M1+ CD35+ Follicular Dendritic Cells but Dissipate Prematurely

(2013) B. Boulianne et al.   JOURNAL OF IMMUNOLOGY

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

Follicular dendritic cells: origin, phenotype, and function in health and disease

(2013) Adriano Aguzzi et al.   TRENDS IN IMMUNOLOGY

IL-7-producing stromal cells are critical for lymph node remodeling

(2012) L. Onder et al.   BLOOD

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

(2012) Nike Julia Krautler et al.   CELL

Expansion of Cortical and Medullary Sinuses Restrains Lymph Node Hypertrophy during Prolonged Inflammation

(2012) K. W. Tan et al.   JOURNAL OF IMMUNOLOGY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

(2008) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE