Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies

The Role of Anti-angiogenesis in the Treatment Landscape of Non-small Cell Lung Cancer – New Combinational Approaches and Strategies of Neovessel Inhibition

(2021) Sophia Daum et al.   Frontiers in Cell and Developmental Biology

STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment

(2021) Manoj Chelvanambi et al.   Journal for ImmunoTherapy of Cancer

Existence of intratumoral tertiary lymphoid structures is associated with immune cells infiltration and predicts better prognosis in early-stage hepatocellular carcinoma

(2020) Hui Li et al.   Aging-US

Tertiary lymphoid structures and associated plasma cells play an important role in the biology of triple-negative breast cancers

(2020) Dominique Yuan Bin Seow et al.   BREAST CANCER RESEARCH AND TREATMENT

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

(2020) Yukun Huang et al.   Nature Communications

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

(2020) Bo He et al.   Cell Reports

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression

(2020) Samir Devalaraja et al.   CELL

Tertiary lymphoid structures in cancer – considerations for patient prognosis

(2020) Luis Munoz-Erazo et al.   Cellular & Molecular Immunology

12‐Chemokine signature, a predictor of tumor recurrence in colorectal cancer

(2020) Ryuma Tokunaga et al.   INTERNATIONAL JOURNAL OF CANCER

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TNFSF14: LIGHTing the Way for Effective Cancer Immunotherapy

(2020) Joseph G. Skeate et al.   Frontiers in Immunology

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

(2020) Balázs Koscsó et al.   Science Immunology

Cell and tissue engineering in lymph nodes for cancer immunotherapy

(2020) Alexander J. Najibi et al.   ADVANCED DRUG DELIVERY REVIEWS

Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

(2020) Nick van Dijk et al.   NATURE MEDICINE

Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

(2020) Qunxing Li et al.   International Journal of Oral Science

Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors

(2020) Wu-Hu Zhang et al.   Journal for ImmunoTherapy of Cancer

Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma

(2019) Axel Lechner et al.   OncoImmunology

APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures

(2019) Guillaume Morcrette et al.   OncoImmunology

A transcriptionally distinct CXCL13+CD103+CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

(2019) Hagma H Workel et al.   Cancer Immunology Research

Single-Cell Analysis Reveals Heterogeneity of High Endothelial Venules and Different Regulation of Genes Controlling Lymphocyte Entry to Lymph Nodes

(2019) Krystle Veerman et al.   Cell Reports

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Type I interferon induces CXCL13 to support ectopic germinal center formation

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma

(2019) Shota Kuwabara et al.   CANCER SCIENCE

Prognostic value of B cells in cutaneous melanoma

(2019) Sara R. Selitsky et al.   Genome Medicine

Adipocytes orchestrate the formation of tertiary lymphoid organs in the creeping fat of Crohn's disease affected mesentery

(2019) Kevin Guedj et al.   JOURNAL OF AUTOIMMUNITY

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

(2019) Saba Nayar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current Perspectives in Cancer Immunotherapy

(2019) Theodoulakis Christofi et al.   Cancers

Oral cancer‐associated tertiary lymphoid structures: gene expression profile and prognostic value

(2019) K. Li et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

(2019) Evelyn Menares et al.   Nature Communications

Meta-analysis of the efficacy and safety of PD-1/PD-L1 inhibitors administered alone or in combination with anti-VEGF agents in advanced hepatocellular carcinoma

(2019) Zhichao Feng et al.   GUT

Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis

(2019) Shanshan Luo et al.   Frontiers in Immunology

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T cell Interplay

(2018) Marilena Gallotta et al.   CANCER RESEARCH

Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

(2018) Li Li et al.   JOURNAL OF HEPATOLOGY

Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer

(2018) Alessandra Nerviani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules

(2018) Bo He et al.   JOURNAL OF PATHOLOGY

EnLIGHTenment of tumour vessel normalization and immunotherapy in glioblastoma

(2018) Lucas Treps   JOURNAL OF PATHOLOGY

Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma

(2018) Anna Maria Wirsing et al.   MODERN PATHOLOGY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis

(2018) S. Esmaeil Dorraji et al.   Scientific Reports

Induction of Tertiary Lymphoid Structures With Antitumor Function by a Lymph Node-Derived Stromal Cell Line

(2018) Genyuan Zhu et al.   Frontiers in Immunology

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

(2018) Gaël Boivin et al.   Frontiers in Oncology

Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis

(2018) Miseon Lee et al.   MODERN PATHOLOGY

Immunomodulation of Tumor Vessels: It Takes Two to Tango

(2018) Anna Johansson-Percival et al.   TRENDS IN IMMUNOLOGY

Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer

(2018) Aliyah M. Weinstein et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies

(2018) Hans A. Schlößer et al.   OncoImmunology

Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

(2018) Iva Truxova et al.   Journal for ImmunoTherapy of Cancer

Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery

(2018) Baharak Bahmani et al.   EBioMedicine

B cell and B cell-related pathways for novel cancer treatments

(2018) Ryuma Tokunaga et al.   CANCER TREATMENT REVIEWS

IL-36γ has proinflammatory effects on human endothelial cells

(2017) Charlie Bridgewood et al.   EXPERIMENTAL DERMATOLOGY

The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine

(2017) Adam K. Savage et al.   JOURNAL OF IMMUNOLOGY

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

(2017) Medya Mara Shikhagaie et al.   Cell Reports

Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction

(2017) Emily J. Colbeck et al.   Cancer Immunology Research

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma

(2017) Ingunn M. Stromnes et al.   Cancer Immunology Research

Tertiary Lymphoid Structures: An Anti-tumor School for Adaptive Immune Cells and an Antibody Factory to Fight Cancer?

(2017) Jean-Luc Teillaud et al.   Frontiers in Immunology

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression

(2017) María de la Luz García-Hernández et al.   Frontiers in Immunology

Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models

(2017) Marieke Robinet et al.   Frontiers in Immunology

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

(2017) Emily Jayne Colbeck et al.   Frontiers in Immunology

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

(2017) Ann Ager   Frontiers in Immunology

Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer

(2017) Cinzia Solinas et al.   Frontiers in Immunology

Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering

(2017) Genyuan Zhu et al.   Frontiers in Immunology

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

(2017) Florian Posch et al.   OncoImmunology

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment

(2017) Aliyah M. Weinstein et al.   OncoImmunology

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy

(2017) Yohsuke Yagawa et al.   Scientific Reports

Ectopic expression of CXCL13, BAFF, APRIL and LT-β is associated with artery tertiary lymphoid organs in giant cell arteritis

(2016) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics

(2016) Olga Schulz et al.   Annual Review of Immunology

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

Systemic DC Activation Modulates the Tumor Microenvironment and Shapes the Long-Lived Tumor-Specific Memory Mediated by CD8+T Cells

(2016) Kanako Shimizu et al.   CANCER RESEARCH

Tumor-infiltrating lymphocyte subsets and tertiary lymphoid structures in pulmonary metastases from colorectal cancer

(2016) Thomas Schweiger et al.   CLINICAL & EXPERIMENTAL METASTASIS

Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer

(2016) D. R. Kroeger et al.   CLINICAL CANCER RESEARCH

A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases

(2016) Anne Montfort et al.   CLINICAL CANCER RESEARCH

Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers

(2016) Marie-Caroline Dieu-Nosjean et al.   IMMUNOLOGICAL REVIEWS

Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2in Newly Formed Tertiary Lymphoid Structures

(2016) Saba Nayar et al.   JOURNAL OF IMMUNOLOGY

Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

(2016) João Conde et al.   NATURE MATERIALS

Local microRNA delivery targets Palladin and prevents metastatic breast cancer

(2016) Avital Gilam et al.   Nature Communications

Tertiary Lymphoid Organs in Cancer Tissues

(2016) Nobuyoshi Hiraoka et al.   Frontiers in Immunology

Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together

(2016) Gareth W. Jones et al.   Frontiers in Immunology

Biosynthesis and Functional Significance of Peripheral Node Addressin in Cancer-Associated TLO

(2016) Aliyah M. Weinstein et al.   Frontiers in Immunology

Gel-Trapped Lymphorganogenic Chemokines Trigger Artificial Tertiary Lymphoid Organs and Mount Adaptive Immune Responses In Vivo

(2016) Yuka Kobayashi et al.   Frontiers in Immunology

High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation

(2016) Nancy H. Ruddle   Frontiers in Immunology

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma

(2016) Isabel Poschke et al.   OncoImmunology

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients

(2015) Stine L Figenschau et al.   BMC CANCER

Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer

(2015) N Hiraoka et al.   BRITISH JOURNAL OF CANCER

Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

(2015) N. A. Giraldo et al.   CLINICAL CANCER RESEARCH

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues

(2015) Gareth W. Jones et al.   IMMUNOLOGY

Tertiary Lymphoid Tissue in the Tumor Microenvironment: From Its Occurrence to Immunotherapeutic Implications

(2015) Giuseppe Di Caro et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Cancer immunotherapy meets biomaterials

(2015) Jeffrey S Weber et al.   NATURE BIOTECHNOLOGY

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

(2015) Francesca Barone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

(2015) J. David Peske et al.   Nature Communications

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

(2015) Paolo Carrega et al.   Nature Communications

High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression

(2015) Diana Costa Bento et al.   OncoImmunology

Hydrogels and Scaffolds for Immunomodulation

(2014) Ankur Singh et al.   ADVANCED MATERIALS

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

(2014) L. Maldonado et al.   Science Translational Medicine

Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

(2014) E. R. Lutz et al.   Cancer Immunology Research

Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues

(2014) Theresa T. Lu et al.   Frontiers in Immunology

Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor Immunity: Potential Tumor-Induced Cytokines/Chemokines that Regulate TLS Formation in Epithelial-Derived Cancers

(2014) Erica Pimenta et al.   Cancers

Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells

(2013) L Chen et al.   CANCER GENE THERAPY

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

M1 macrophages act as LTβR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis

(2013) Kevin Guedj et al.   CARDIOVASCULAR RESEARCH

Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

(2013) R. Remark et al.   CLINICAL CANCER RESEARCH

TNFα-dependent development of lymphoid tissue in the absence of RORγt+ lymphoid tissue inducer cells

(2013) G C Furtado et al.   Mucosal Immunology

Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity

(2013) Lu Chen et al.   Frontiers in Immunology

A role for Th17 cells in the regulation of tertiary lymphoid follicles

(2012) Jane L. Grogan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-36γ/IL-1F9, an Innate T-bet Target in Myeloid Cells

(2012) Malte Bachmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma

(2012) Sharon Stranford et al.   Frontiers in Immunology

Unique Ectopic Lymph Node-Like Structures Present in Human Primary Colorectal Carcinoma Are Identified by Immune Gene Array Profiling

(2011) Domenico Coppola et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor microenvironment is multifaceted

(2011) Catherine Sautès-Fridman et al.   CANCER AND METASTASIS REVIEWS

Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

(2011) L. Martinet et al.   CANCER RESEARCH

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Cancer Immunotherapy Comes of Age

(2011) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

An injectable synthetic immune-priming center mediates efficient T-cell class switching and T-helper 1 response against B cell lymphoma

(2011) Ankur Singh et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

(2011) Christine Moussion et al.   NATURE

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

(2010) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The unexpected role of lymphotoxin β receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development

(2010) M J Wolf et al.   ONCOGENE

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Synthesis of artificial lymphoid tissue with immunological function

(2010) Yuka Kobayashi et al.   TRENDS IN IMMUNOLOGY

Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue

(2010) Soledad Mac Keon et al.   VACCINE

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus–infected mice

(2009) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic Germinal Centers Are Rare in Sjogren's Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells

(2009) L. Le Pottier et al.   JOURNAL OF IMMUNOLOGY

Infection-mimicking materials to program dendritic cells in situ

(2009) Omar A. Ali et al.   NATURE MATERIALS

Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways

(2008) Carl F. Ware   IMMUNOLOGICAL REVIEWS