Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks

Development and Immunological Function of Lymph Node Stromal Cells

(2021) Natalia Barbara Pikor et al.   JOURNAL OF IMMUNOLOGY

Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity

(2021) Alejandro Prados et al.   NATURE IMMUNOLOGY

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

(2021) Varun N. Kapoor et al.   NATURE IMMUNOLOGY

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

(2020) Sung Yong Choi et al.   Nature Communications

Topological Structure and Robustness of the Lymph Node Conduit System

(2020) Mario Novkovic et al.   Cell Reports

Defining the Design Principles of Skin Epidermis Postnatal Growth

(2020) Sophie Dekoninck et al.   CELL

The extracellular matrix in development

(2020) David A. Cruz Walma et al.   DEVELOPMENT

Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones

(2020) Anne Chauveau et al.   IMMUNITY

Lymph node stromal cells: cartographers of the immune system

(2020) Akshay T. Krishnamurty et al.   NATURE IMMUNOLOGY

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

(2020) Natalia B. Pikor et al.   NATURE IMMUNOLOGY

FALC stromal cells define a unique immunological niche for the surveillance of serous cavities

(2020) Lucy H Jackson-Jones et al.   CURRENT OPINION IN IMMUNOLOGY

The fibroblastic T cell niche in lymphoid tissues

(2020) Anne L Fletcher et al.   CURRENT OPINION IN IMMUNOLOGY

Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells

(2020) Christian Perez-Shibayama et al.   Science Immunology

Lymph node conduits transport virions for rapid T cell activation

(2019) Glennys V. Reynoso et al.   NATURE IMMUNOLOGY

Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp

(2019) Hung-Wei Cheng et al.   Nature Communications

Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

(2019) Kim M. van Pul et al.   Journal for ImmunoTherapy of Cancer

Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

(2019) Rathan Joy Komban et al.   Nature Communications

Mechanosensing by Peyer’s patch stroma regulates lymphocyte migration and mucosal antibody responses

(2019) Jonathan E. Chang et al.   NATURE IMMUNOLOGY

Quantification of the Whole Lymph Node Vasculature Based on Tomography of the Vessel Corrosion Casts

(2019) M. Jafarnejad et al.   Scientific Reports

Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion

(2019) Victor G. Martinez et al.   Cell Reports

High-resolution 3D imaging and topological mapping of the lymph node conduit system

(2019) Inken D. Kelch et al.   PLOS BIOLOGY

Lymphatic System Flows

(2018) James E. Moore et al.   Annual Review of Fluid Mechanics

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

(2018) Hsin-Ying Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin and microtubule crosstalk in the regulation of cellular processes

(2018) Susan E. LaFlamme et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Fresh View on Lymph Node Organogenesis

(2018) Lucas Onder et al.   TRENDS IN IMMUNOLOGY

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

(2018) Joern Pezoldt et al.   Nature Communications

Quantitative Profiling of the Lymph Node Clearance Capacity

(2018) Cristina C. Clement et al.   Scientific Reports

The conduit system exports locally secreted IgM from lymph nodes

(2018) Guilhem R. Thierry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis

(2017) Lucas Onder et al.   IMMUNITY

Inflammatory Manifestations of Lymphedema

(2017) Catherine Ly et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distribution, location, and transcriptional profile of Peyer’s patch conventional DC subsets at steady state and under TLR7 ligand stimulation

(2017) J Bonnardel et al.   Mucosal Immunology

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

(2017) Ann Ager   Frontiers in Immunology

Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy

(2016) Susan N. Thomas et al.   Annual Review of Biomedical Engineering

Peyer's patches: organizing B-cell responses at the intestinal frontier

(2016) Andrea Reboldi et al.   IMMUNOLOGICAL REVIEWS

Dendritic cells in remodeling of lymph nodes during immune responses

(2016) Sophie E. Acton et al.   IMMUNOLOGICAL REVIEWS

Endothelial Plasmalemma Vesicle–Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells

(2016) Raul Elgueta et al.   JOURNAL OF IMMUNOLOGY

Lymphatic pumping: mechanics, mechanisms and malfunction

(2016) Joshua P. Scallan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

(2016) Mario Novkovic et al.   PLOS BIOLOGY

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes

(2015) Mohammad Jafarnejad et al.   Lymphatic Research and Biology

Inflammation-induced formation of fat-associated lymphoid clusters

(2015) Cécile Bénézech et al.   NATURE IMMUNOLOGY

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

(2015) Pia Rantakari et al.   NATURE IMMUNOLOGY

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes

(2015) Mohammad Jafarnejad et al.   Lymphatic Research and Biology

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

(2014) Sophie E. Acton et al.   NATURE

The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

(2014) Jillian L Astarita et al.   NATURE IMMUNOLOGY

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

(2014) Viviana Cremasco et al.   NATURE IMMUNOLOGY

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

(2013) Qian Chai et al.   IMMUNITY

Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues

(2013) Jacob D. Estes   IMMUNOLOGICAL REVIEWS

Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

(2013) J. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes

(2013) C.-Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

(2012) Nike Julia Krautler et al.   CELL

The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition

(2012) Radu V. Stan et al.   DEVELOPMENTAL CELL

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

(2012) Sophie E. Acton et al.   IMMUNITY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans

(2011) Alexander Link et al.   AMERICAN JOURNAL OF PATHOLOGY

Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant

(2011) J. Mattsson et al.   JOURNAL OF IMMUNOLOGY

CD169+ macrophages at the crossroads of antigen presentation

(2011) Luisa Martinez-Pomares et al.   TRENDS IN IMMUNOLOGY

Ultrastructural localization of extracellular matrix proteins of the lymph node cortex: evidence supporting the reticular network as a pathway for lymphocyte migration

(2010) Gregg P Sobocinski et al.   BMC IMMUNOLOGY

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

(2010) Matteo Iannacone et al.   NATURE

B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells

(2009) M. Bajenoff et al.   BLOOD

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

(2009) Ramon Roozendaal et al.   IMMUNITY

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

(2009) Javier Rangel-Moreno et al.   IMMUNITY

Contractile Physiology of Lymphatics

(2009) David C. Zawieja   Lymphatic Research and Biology