Podoplanin: An emerging cancer biomarker and therapeutic target

Podoplanin expression in peritumoral keratinocytes predicts aggressive behavior in extramammary Paget's disease

(2017) Zaigen Cho et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

(2017) Julie Rayes et al.   Nature Communications

Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation

(2017) Kenichi Miyata et al.   Scientific Reports

Estradiol Promotes Breast Cancer Cell Migration via Recruitment and Activation of Neutrophils

(2017) Gabriela Vazquez Rodriguez et al.   Cancer Immunology Research

Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity

(2017) Mika K. Kaneko et al.   Cancer Medicine

A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis

(2017) Ai Takemoto et al.   Scientific Reports

Single cell time-lapse analysis reveals that podoplanin enhances cell survival and colony formation capacity of squamous cell carcinoma cells

(2017) Tomoyuki Miyashita et al.   Scientific Reports

Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice

(2016) Jun Asai et al.   AMERICAN JOURNAL OF PATHOLOGY

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

(2016) T. A. M. Claushuis et al.   BLOOD

Antitumor effect of novel anti-podoplanin antibody NZ-12 against malignant pleural mesothelioma in an orthotopic xenograft model

(2016) Shinji Abe et al.   CANCER SCIENCE

CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains

(2016) S. Shiina et al.   Cancer Immunology Research

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice

(2015) A. Gros et al.   BLOOD

PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility

(2015) Harini Krishnan et al.   EXPERIMENTAL CELL RESEARCH

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

(2015) Yao-Wen Chang et al.   Oncotarget

Targeting a novel domain in podoplanin for inhibiting platelet-mediated tumor metastasis

(2015) Takaya Sekiguchi et al.   Oncotarget

Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model

(2015) Xiaoyun Chen et al.   Scientific Reports

Podoplanin expression in cancer-associated fibroblasts predicts aggressive behavior in melanoma

(2014) Saori Kan et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Disulfiram Suppresses Growth of the Malignant Pleural Mesothelioma Cells in Part by Inducing Apoptosis

(2014) Vino T. Cheriyan et al.   PLoS One

A Platform of C-type Lectin-like Receptor CLEC-2 for Binding O -Glycosylated Podoplanin and Nonglycosylated Rhodocytin

(2014) Masamichi Nagae et al.   STRUCTURE

Podoplanin—a novel marker in oral carcinogenesis

(2014) Niharika Swain et al.   TUMOR BIOLOGY

LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma

(2013) J. T. Yeung et al.   CLINICAL CANCER RESEARCH

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility

(2013) Harini Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Targeting Therapy of Malignant Mesothelioma Using Anti-Podoplanin Antibody

(2013) S. Abe et al.   JOURNAL OF IMMUNOLOGY

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic Value of Podoplanin Expression in Oral Squamous Cell Carcinoma―A Regression Model Auxiliary to UICC Classification

(2013) Sachiko Seki et al.   PATHOLOGY & ONCOLOGY RESEARCH

Thrombocytopenia as a Predictor of Severe Acute Kidney Injury in Patients with Hantaan Virus Infections

(2013) Meiliang Wang et al.   PLoS One

CARP-1 Functional Mimetics: A Novel Class of Small Molecule Inhibitors of Medulloblastoma Cell Growth

(2013) Abdelkader E. Ashour et al.   PLoS One

Platelets Promote Tumor Growth and Metastasis via Direct Interaction between Aggrus/Podoplanin and CLEC-2

(2013) Satoshi Takagi et al.   PLoS One

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway

(2013) Binggang Xiang et al.   Nature Communications

Value of Podoplanin as an Immunohistochemical Marker in Tumor Diagnosis

(2013) Nelson G. Ordóñez   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors

(2012) Vidyalakshmi Chandramohan et al.   INTERNATIONAL JOURNAL OF CANCER

Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration

(2012) Jhon Alberto Ochoa-Alvarez et al.   PLoS One

Podoplanin: emerging functions in development, the immune system, and cancer

(2012) Jillian L. Astarita et al.   Frontiers in Immunology

Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx

(2010) Gerhard Frank Huber et al.   INTERNATIONAL JOURNAL OF CANCER

Src Induces Podoplanin Expression to Promote Cell Migration

(2010) Yongquan Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical care and the global burden of critical illness in adults

(2010) Neill KJ Adhikari et al.   LANCET

Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations

(2010) Matthias Kreppel et al.   VIRCHOWS ARCHIV

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

(2009) C. Carpenito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431

(2008) Naho Atsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammation induces hemorrhage in thrombocytopenia

(2008) T. Goerge et al.   BLOOD

Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype

(2008) H. Rubin   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA