Tertiary Lymphoid Structures as Mediators of Immunotherapy Response

Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

(2022) Assia Asrir et al.   CANCER CELL

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

(2022) Ricardo A. Chaurio et al.   IMMUNITY

Tertiary lymphoid structures in cancer

(2022) Ton N. Schumacher et al.   SCIENCE

Tertiary lymphoid structures marker CXCL13 is associated with better survival for patients with advanced-stage bladder cancer treated with immunotherapy

(2021) Clarice S. Groeneveld et al.   EUROPEAN JOURNAL OF CANCER

Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy

(2021) Shota Aoyama et al.   Frontiers in Immunology

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

(2021) Anthony B. Rodriguez et al.   Cell Reports

Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma

(2021) Kevin T Lynch et al.   Journal for ImmunoTherapy of Cancer

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice

(2021) Francesca R. Delvecchio et al.   Cellular and Molecular Gastroenterology and Hepatology

The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer

(2021) Nick van Dijk et al.   Frontiers in Immunology

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

The Prognostic Implications of Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Systematic Review and Meta-Analysis

(2020) Gregory E. Idos et al.   Scientific Reports

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

(2020) Isaure Vanmeerbeek et al.   OncoImmunology

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

(2020) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

(2020) Nick van Dijk et al.   NATURE MEDICINE

Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma

(2020) Jianjun Gao et al.   NATURE MEDICINE

The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma

(2020) Matthias Pinter et al.   JAMA Oncology

Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure

(2020) Ziying Lin et al.   Scientific Reports

Lymphoid aggregates in desmoplastic melanoma have features of tertiary lymphoid structures

(2018) Anne M. Stowman et al.   MELANOMA RESEARCH

Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

(2018) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers

(2017) Xia Liu et al.   ONCOLOGIST

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer

(2017) In Hye Song et al.   Cancer Research and Treatment

Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction

(2017) Emily J. Colbeck et al.   Cancer Immunology Research

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

(2017) Ann Ager   Frontiers in Immunology

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

(2017) Florian Posch et al.   OncoImmunology

Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic Intervention

(2016) Catherine Sautès-Fridman et al.   Frontiers in Immunology

Prognostic Significance of Tumor-Infiltrating Lymphocytes and the Tertiary Lymphoid Structures in HER2-Positive Breast Cancer Treated With Adjuvant Trastuzumab

(2015) Hee Jin Lee et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients

(2015) Stine L Figenschau et al.   BMC CANCER

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Occurrence of Tertiary Lymphoid Tissue Is Associated with T-Cell Infiltration and Predicts Better Prognosis in Early-Stage Colorectal Cancers

(2014) G. Di Caro et al.   CLINICAL CANCER RESEARCH

B Cells and Ectopic Follicular Structures: Novel Players in Anti-Tumor Programming with Prognostic Power for Patients with Metastatic Colorectal Cancer

(2014) Anastasia Meshcheryakova et al.   PLoS One

CD4+ follicular helper T cell infiltration predicts breast cancer survival

(2013) Chunyan Gu-Trantien et al.   JOURNAL OF CLINICAL INVESTIGATION

The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer

(2012) Z MA Mohammed et al.   BRITISH JOURNAL OF CANCER

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

(2012) Arcadi Cipponi et al.   CANCER RESEARCH

Tertiary lymphoid organs in infection and autoimmunity

(2012) Katrijn Neyt et al.   TRENDS IN IMMUNOLOGY

High endothelial venules (HEVs) in human melanoma lesions

(2012) Ludovic Martinet et al.   OncoImmunology

Unique Ectopic Lymph Node-Like Structures Present in Human Primary Colorectal Carcinoma Are Identified by Immune Gene Array Profiling

(2011) Domenico Coppola et al.   AMERICAN JOURNAL OF PATHOLOGY

Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node

(2008) Friederike Pfeiffer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures

(2008) Marie-Caroline Dieu-Nosjean et al.   JOURNAL OF CLINICAL ONCOLOGY