Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders

C19orf12 ablation causes ferroptosis in mitochondrial membrane protein-associated with neurodegeneration

(2022) Changjuan Shao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

(2022) Johannes Levin et al.   EBioMedicine

Lifetime risk of autosomal recessive neurodegeneration with brain iron accumulation (NBIA) disorders calculated from genetic databases

(2022) Hana Kolarova et al.   EBioMedicine

Is Chelation Therapy a Potential Treatment for Parkinson’s Disease?

(2021) Roberta J. Ward et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population

(2021) Hui-Hui Fan et al.   Frontiers in Neuroscience

Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders

(2021) Vassilena Iankova et al.   Frontiers in Neurology

Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

(2021) I. Friedrich et al.   Acta Neuropathologica Communications

WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis

(2021) Qiuhong Xiong et al.   Frontiers in Molecular Biosciences

Consensus clinical management guideline for beta‐propeller protein‐associated neurodegeneration

(2021) Jenny L Wilson et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse

(2021) Caroline A. Biagosch et al.   MAMMALIAN GENOME

A De Novo case of autosomal dominant mitochondrial membrane protein‐associated neurodegeneration

(2021) Stuart Fraser et al.   Molecular Genetics & Genomic Medicine

Surface Plasmon Resonance Identifies High-Affinity Binding of l-DOPA to Siderocalin/Lipocalin-2 through Iron–Siderophore Action: Implications for Parkinson’s Disease Treatment

(2021) Sammy Alhassen et al.   ACS Chemical Neuroscience

PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia–parkinsonism type 14 and can be relieved by DHA treatment in animal models

(2021) Tu-Hsueh Yeh et al.   EXPERIMENTAL NEUROLOGY

Iron Accumulation and Changes in Cellular Organelles in WDR45 Mutant Fibroblasts

(2021) Hye Eun Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A neurodegeneration gene, WDR45 , links impaired ferritinophagy to iron accumulation

(2021) Luisa Aring et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative evaluation of brain iron accumulation in different stages of Parkinson's disease

(2021) Kailyn R. Li et al.   JOURNAL OF NEUROIMAGING

Dissecting the Phenotype and Genotype of PLA2G6 ‐Related Parkinsonism

(2021) Francesca Magrinelli et al.   MOVEMENT DISORDERS

Physiological significance of WDR45, a responsible gene for β-propeller protein associated neurodegeneration (BPAN), in brain development

(2021) Mariko Noda et al.   Scientific Reports

Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins

(2021) Milagros Pereira Luppi et al.   Cell Reports

A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data

(2021) Gennaro Pagano et al.   Frontiers in Neurology

Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling

(2020) Minjing Ke et al.   Cell Death & Disease

Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations

(2020) Stephen Mullin et al.   JAMA Neurology

Genetics of Parkinson's disease: An introspection of its journey towards precision medicine

(2020) Sara Bandres-Ciga et al.   NEUROBIOLOGY OF DISEASE

Real-Time Characterization of Cell Membrane Disruption by α-Synuclein Oligomers in Live SH-SY5Y Neuroblastoma Cells

(2020) Jacob Parres-Gold et al.   ACS Chemical Neuroscience

Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa

(2020) Roberto Cilia et al.   BRAIN

Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial

(2020) Dieter Volc et al.   LANCET NEUROLOGY

The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson’s Disease: A Feasibility Study

(2020) Xuemei Huang et al.   Journal of Parkinsons Disease

Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys

(2020) Diana Alarcón-Arís et al.   EBioMedicine

Dominant mitochondrial membrane protein-associated neurodegeneration (MPAN) variants cluster within a specific C19orf12 isoform

(2020) Olivia J. Rickman et al.   PARKINSONISM & RELATED DISORDERS

A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo

(2020) Mahalakshmi Somayaji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroinflammation and protein pathology in Parkinson’s disease dementia

(2020) Antonina Kouli et al.   Acta Neuropathologica Communications

The Downregulation of c19orf12 Negatively Affects Neuronal and Musculature Development in Zebrafish Embryos

(2020) Luca Mignani et al.   Frontiers in Cell and Developmental Biology

Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease

(2019) Dilan Athauda et al.   JAMA Neurology

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

(2019) Iria Carballo-Carbajal et al.   Nature Communications

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

(2019) Clifford M. Cassidy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

l ‐3,4‐dihydroxyphenylalanine ( l ‐DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha‐synuclein mouse models of Parkinson's disease

(2019) Jessica L. Billings et al.   JOURNAL OF NEUROCHEMISTRY

Iron deposition in Parkinson’s disease by quantitative susceptibility mapping

(2019) Qiqi Chen et al.   BMC NEUROSCIENCE

Regional High Iron in the Substantia Nigra Differentiates Parkinson’s Disease Patients From Healthy Controls

(2019) Kiarash Ghassaban et al.   Frontiers in Aging Neuroscience

Autosomal dominant mitochondrial membrane protein‐associated neurodegeneration (MPAN)

(2019) Allison Gregory et al.   Molecular Genetics & Genomic Medicine

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

(2019) Huida Wan et al.   Autophagy

Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning

(2019) Junbing Wu et al.   Cell Reports

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

(2019) Akio Mori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

(2019) Nicolas Giguère et al.   PLoS Genetics

Nilotinib Effects on Safety, Tolerability, and Potential Biomarkers in Parkinson Disease

(2019) Fernando. L. Pagan et al.   JAMA Neurology

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

(2019) Margarita Chumarina et al.   Acta Neuropathologica Communications

A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Dopamine D1 Receptor Partial Agonist, PF-06669571, in Subjects with Idiopathic Parkinson’s Disease

(2018) Rachel Gurrell et al.   CLINICAL DRUG INVESTIGATION

Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein

(2018) Dinendra L. Abeyawardhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model

(2018) Ching-Chi Chiu et al.   MOLECULAR NEUROBIOLOGY

Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration

(2018) Konstantin G. Iliadi et al.   Scientific Reports

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

(2018) Philip Seibler et al.   BRAIN

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine, oxidative stress and protein-quinone modifications in Parkinson's and other neurodegenerative diseases

(2018) Enrico Monzani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

(2017) Dilan Athauda et al.   LANCET

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain

(2017) Sian Genoud et al.   Metallomics

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

(2017) Danielle E Mor et al.   NATURE NEUROSCIENCE

The p.Thr11Met mutation in c19orf12 is frequent among adult Turkish patients with MPAN

(2017) Simone Olgiati et al.   PARKINSONISM & RELATED DISORDERS

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway

(2017) Ching-Chi Chiu et al.   Oncotarget

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function

(2017) N. Plotegher et al.   Scientific Reports

Patient Affected by Beta-Propeller Protein-Associated Neurodegeneration: A Therapeutic Attempt with Iron Chelation Therapy

(2017) Mattia Fonderico et al.   Frontiers in Neurology

Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN)

(2017) Rosaria Ingrassia et al.   Frontiers in Genetics

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance

(2017) Zhuo Liu et al.   Scientific Reports

Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson’s Disease

(2016) Emanuele Ferrari et al.   ACS Chemical Neuroscience

Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein

(2016) Jon W. Werner-Allen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7

(2016) Bao Wang et al.   Autophagy

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry

(2016) Antje Biesemeier et al.   JOURNAL OF NEUROCHEMISTRY

Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons

(2016) F. Philippart et al.   JOURNAL OF NEUROSCIENCE

Contrast mechanisms associated with neuromelanin-MRI

(2016) Paula Trujillo et al.   MAGNETIC RESONANCE IN MEDICINE

Long-term effects of rasagiline and the natural history of treated Parkinson's disease

(2016) Olivier Rascol et al.   MOVEMENT DISORDERS

Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis

(2016) Dana Yaffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

(2016) Marija Iljina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals

(2016) Kelly M. Lohr et al.   TOXICOLOGICAL SCIENCES

Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease

(2016) Qingde Zhou et al.   Nature Communications

Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection

(2016) Sarah Plum et al.   Scientific Reports

The autophagy geneWdr45/Wipi4regulates learning and memory function and axonal homeostasis

(2015) Yan G Zhao et al.   Autophagy

Loss ofPLA2G6leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

(2015) Kerri J. Kinghorn et al.   BRAIN

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

Changes in Neuronal Dopamine Homeostasis following 1-Methyl-4-phenylpyridinium (MPP+) Exposure

(2015) Se Joon Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-independent phospholipases A2and their roles in biological processes and diseases

(2015) Sasanka Ramanadham et al.   JOURNAL OF LIPID RESEARCH

Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane

(2015) Carla R. Pacheco et al.   JOURNAL OF NEUROCHEMISTRY

Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

(2015) Nikenza Viceconte et al.   Journal of Neuroinflammation

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for  -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

(2015) F.-L. Tang et al.   JOURNAL OF NEUROSCIENCE

JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death

(2015) Won-Seok Choi et al.   TOXICOLOGY

Mutations of C19orf12, coding for a transmembrane glycine zipper containing mitochondrial protein, cause mis-localization of the protein, inability to respond to oxidative stress and increased mitochondrial Ca2+

(2015) Paola Venco et al.   Frontiers in Genetics

Neuropathology of Beta-propeller protein associated neurodegeneration (BPAN): a new tauopathy

(2015) R. Paudel et al.   Acta Neuropathologica Communications

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset

(2014) Johannes Levin et al.   ACTA NEUROPATHOLOGICA

The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa

(2014) R. Cilia et al.   BRAIN

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

(2014) Guoxiang Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

(2014) C. Pifl et al.   JOURNAL OF NEUROSCIENCE

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial

(2014) PD MED Collaborative Group   LANCET

Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein

(2014) Yunden Jinsmaa et al.   NEUROSCIENCE LETTERS

Impairment of Drosophila Orthologs of the Human Orphan Protein C19orf12 Induces Bang Sensitivity and Neurodegeneration

(2014) Arcangela Iuso et al.   PLoS One

Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo

(2014) Kelly M. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Dopamine Is Involved in the Herbicide Paraquat-Induced Dopaminergic Cell Death

(2014) Yasuhiko Izumi et al.   TOXICOLOGICAL SCIENCES

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

(2014) Carolina Cebrián et al.   Nature Communications

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Parkinson’s disease is associated with altered expression of CaV1 channels and calcium-binding proteins

(2013) Michael J. Hurley et al.   BRAIN

Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

(2013) Susan J. Hayflick et al.   BRAIN

Complexity of dopamine metabolism

(2013) Johannes Meiser et al.   Cell Communication and Signaling

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

(2013) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Reduced vesicular storage of catecholamines causes progressive degeneration in the locus ceruleus

(2013) Tonya N. Taylor et al.   NEUROPHARMACOLOGY

Brain Dopamine–Serotonin Vesicular Transport Disease and Its Treatment

(2013) Jennifer J. Rilstone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry

(2013) Donna M. Omiatek et al.   Scientific Reports

Exome Sequencing Reveals De Novo WDR45 Mutations Causing a Phenotypically Distinct, X-Linked Dominant Form of NBIA

(2012) Tobias B. Haack et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

(2012) Pabla Aguirre et al.   BIOMETALS

A molecular signature in blood identifies early Parkinson’s disease

(2012) Leonid Molochnikov et al.   Molecular Neurodegeneration

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Association between polychlorinated biphenyls and Parkinson's disease neuropathology

(2012) Jaime M. Hatcher-Martin et al.   NEUROTOXICOLOGY

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

(2012) S. Iannaccone et al.   PARKINSONISM & RELATED DISORDERS

Human SOD2 Modification by Dopamine Quinones Affects Enzymatic Activity by Promoting Its Aggregation: Possible Implications for Parkinson’s Disease

(2012) Elisa Belluzzi et al.   PLoS One

Neuromelanins of Human Brain Have Soluble and Insoluble Components with Dolichols Attached to the Melanic Structure

(2012) Mireille Engelen et al.   PLoS One

Intracranial Lesions with High Signal Intensity on T1-weighted MR Images: Differential Diagnosis

(2012) Daniel T. Ginat et al.   RADIOGRAPHICS

Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders

(2011) Yu Lu et al.   ACS Chemical Neuroscience

Absence of an Orphan Mitochondrial Protein, C19orf12, Causes a Distinct Clinical Subtype of Neurodegeneration with Brain Iron Accumulation

(2011) Monika B. Hartig et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Neuromelanin is an immune stimulator for dendritic cells in vitro

(2011) Uwe Oberländer et al.   BMC NEUROSCIENCE

Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system

(2011) David W. Anderson et al.   BRAIN RESEARCH

Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease

(2011) Muhammad Zahid et al.   IUBMB LIFE

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes

(2011) Olivier Rascol et al.   LANCET NEUROLOGY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Correction: Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine quinones interact with α-synuclein to form unstructured adducts

(2010) Marco Bisaglia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2Ain Vitroandin Vivo

(2010) Haiyan Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Oxidative Stress Partially Contributes to Iron-Induced Alpha-Synuclein Aggregation in SK-N-SH Cells

(2010) Wenjing Li et al.   NEUROTOXICITY RESEARCH

The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis

(2010) W. Michael Panneton et al.   PLoS One

Dopamine D2receptor knockout mice develop features of Parkinson disease

(2009) Rogan B. Tinsley et al.   ANNALS OF NEUROLOGY

Products of Oxidative Stress Inhibit Aldehyde Oxidation and Reduction Pathways in Dopamine Catabolism Yielding Elevated Levels of a Reactive Intermediate

(2009) Yunden Jinsmaa et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Reactivity of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite, Is Dependent on Both the Aldehyde and the Catechol

(2009) Jennifer N. Rees et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes

(2009) Yong Peng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner

(2009) Chi L.L. Pham et al.   JOURNAL OF MOLECULAR BIOLOGY

Endogenous Calcium Buffering Capacity of Substantia Nigral Dopamine Neurons

(2009) R. C. Foehring et al.   JOURNAL OF NEUROPHYSIOLOGY

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Nonmotor Symptoms of Parkinson's Disease Revealed in an Animal Model with Reduced Monoamine Storage Capacity

(2009) T. N. Taylor et al.   JOURNAL OF NEUROSCIENCE

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

(2009) Wei Zhang et al.   NEUROTOXICITY RESEARCH

Dopamine-Induced Conformational Changes in Alpha-Synuclein

(2009) Tiago F. Outeiro et al.   PLoS One

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

(2008) Luigi Zecca et al.   ACTA NEUROPATHOLOGICA

Phospholipase A2 Biochemistry

(2008) John E. Burke et al.   CARDIOVASCULAR DRUGS AND THERAPY

R632W mutation inPLA2G6segregates with dystonia-parkinsonism in a consanguineous Iranian family

(2008) F. Sina et al.   EUROPEAN JOURNAL OF NEUROLOGY

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

(2008) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice

(2008) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Complex I Inhibitor Rotenone Inhibits and Redistributes Vesicular Monoamine Transporter 2 via Nitration in Human Dopaminergic SH-SY5Y Cells

(2008) M. Watabe et al.   MOLECULAR PHARMACOLOGY

Fourteen-year final report of the randomized PDRG-UK trial comparing three initial treatments in PD

(2008) R. Katzenschlager et al.   NEUROLOGY

Neurodegeneration associated with genetic defects in phospholipase A2

(2008) A. Gregory et al.   NEUROLOGY

Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN)

(2008) M. A. Kurian et al.   NEUROLOGY

Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat

(2008) R.G. Nair-Roberts et al.   NEUROSCIENCE

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

(2008) Fernando E. Herrera et al.   PLoS One

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

(2008) L. Zecca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA