WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis

β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

(2021) Cuicui Ji et al.   CURRENT BIOLOGY

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

(2019) Huida Wan et al.   Autophagy

PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance

(2019) Yan Wang et al.   ENVIRONMENTAL POLLUTION

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl

(2019) Qiuhong Xiong et al.   Molecular Genetics & Genomic Medicine

Iron overload inhibits late stage autophagic flux leading to insulin resistance

(2019) James Won Suk Jahng et al.   EMBO REPORTS

Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction

(2019) Jyotirmoy Rakshit et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

(2019) Zhenyuan Tang et al.   Cell Reports

Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway

(2019) Tiantian Huo et al.   BRAIN RESEARCH BULLETIN

Lipid peroxidation in neurodegeneration

(2019) Carmen Peña-Bautista et al.   CLINICA CHIMICA ACTA

Hijacking intracellular membranes to feed autophagosomal growth

(2019) Leopoldo Staiano et al.   FEBS LETTERS

Iron Overload Impairs Autophagy: Effects of Rapamycin in Ameliorating Iron-Related Memory Deficits

(2019) Vanise Hallas Uberti et al.   MOLECULAR NEUROBIOLOGY

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

(2018) Philip Seibler et al.   BRAIN

ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2

(2018) Qiuhong Xiong et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation

(2018) Peng Yang et al.   Food & Function

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Novel WDR45 mutation causing beta-propeller protein associated neurodegeneration (BPAN) in two monozygotic twins

(2017) Rui Araújo et al.   JOURNAL OF NEUROLOGY

The transferrin receptor: the cellular iron gate

(2017) Elena Gammella et al.   Metallomics

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

(2017) Daniela Bakula et al.   Nature Communications

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Evaluating the effectiveness of transferrin receptor-1 (TfR1) as a magnetic resonance reporter gene

(2016) Sofia M. Pereira et al.   Contrast Media & Molecular Imaging

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells

(2015) Sofia Pereira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transferrin receptors and glioblastoma multiforme: Current findings and potential for treatment

(2015) Brittany Voth et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions

(2015) Q. Xiong et al.   Open Biology

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

(2015) Kapil Sirohi et al.   PLoS One

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor

(2013) H. Fujita et al.   JOURNAL OF CELL SCIENCE

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1

(2013) D H Pham et al.   ONCOGENE

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo

(2013) Shaina L. Byrne et al.   PLoS One

Exome Sequencing Reveals De Novo WDR45 Mutations Causing a Phenotypically Distinct, X-Linked Dominant Form of NBIA

(2012) Tobias B. Haack et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

(2011) Hong-Min Ni et al.   Autophagy

Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

(2011) Ryo Tachiyama et al.   GENES TO CELLS

Iron in neuronal function and dysfunction

(2010) Gabriela A. Salvador   BIOFACTORS

The Small-Molecule Iron Transport Inhibitor Ferristatin/NSC306711 Promotes Degradation of the Transferrin Receptor

(2008) Lior Horonchik et al.   CHEMISTRY & BIOLOGY

Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells

(2008) S. R. Chirasani et al.   JOURNAL OF MOLECULAR MEDICINE-JMM