A neurodegeneration gene, WDR45 , links impaired ferritinophagy to iron accumulation

β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

(2021) Cuicui Ji et al.   CURRENT BIOLOGY

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

(2019) Huida Wan et al.   Autophagy

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

Neurodegeneration with brain iron accumulation: Insights into the mitochondria dysregulation

(2019) Zhi-Bin Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Impact of dietary manganese on experimental colitis in mice

(2019) Eun‐Kyung Choi et al.   FASEB JOURNAL

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Oxidative stress and neurodegeneration: the involvement of iron

(2018) Alessia Carocci et al.   BIOMETALS

Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders

(2018) Eun-Kyung Choi et al.   Scientific Reports

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

(2018) Philip Seibler et al.   BRAIN

Ferroportin disease mutations influence manganese accumulation and cytotoxicity

(2018) Eun-Kyung Choi et al.   FASEB JOURNAL

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metals and neurodegenerative diseases. A systematic review

(2017) Calogero Edoardo Cicero et al.   ENVIRONMENTAL RESEARCH

Iron transport proteins: Gateways of cellular and systemic iron homeostasis

(2017) Mitchell D. Knutson   JOURNAL OF BIOLOGICAL CHEMISTRY

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes

(2017) Ashley M. Jacobi et al.   METHODS

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

(2017) Daniela Bakula et al.   Nature Communications

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN)

(2017) Rosaria Ingrassia et al.   Frontiers in Genetics

A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity

(2016) Jack T. Rogers et al.   JOURNAL OF NEUROCHEMISTRY

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

The autophagy geneWdr45/Wipi4regulates learning and memory function and axonal homeostasis

(2015) Yan G Zhao et al.   Autophagy

Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2

(2015) Nicolas Montalbetti et al.   BIOCHEMICAL PHARMACOLOGY

Reinterpreting the best biomarker of oxidative stress: The 8-iso-PGF2α/PGF2α ratio distinguishes chemical from enzymatic lipid peroxidation

(2015) Thomas J. van ‘t Erve et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons

(2015) Changyi Ji et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders

(2015) Natalia P. Mena et al.   MITOCHONDRION

Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories

(2015) C. E. Arber et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms

(2014) Sonia Levi et al.   Frontiers in Pharmacology

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders

(2014) Pamela J. Urrutia et al.   Frontiers in Pharmacology

Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc

(2013) Colin J. Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

(2013) Susan J. Hayflick et al.   BRAIN

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Exome Sequencing Reveals De Novo WDR45 Mutations Causing a Phenotypically Distinct, X-Linked Dominant Form of NBIA

(2012) Tobias B. Haack et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

(2012) Michael D. Garrick et al.   BIOMETALS

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes

(2011) Qun Lu et al.   DEVELOPMENTAL CELL

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Iron in neuronal function and dysfunction

(2010) Gabriela A. Salvador   BIOFACTORS

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Roles of the Lipid-binding Motifs of Atg18 and Atg21 in the Cytoplasm to Vacuole Targeting Pathway and Autophagy

(2010) Usha Nair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

(2010) Isaac Túnez et al.   MOLECULES

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity

(2009) Susana J. Oliveira et al.   PLoS One

Tim-2 is the receptor for H-ferritin on oligodendrocytes

(2008) Bozho Todorich et al.   JOURNAL OF NEUROCHEMISTRY