Lifelong docosahexaenoic acid intervention ameliorates aging in the telomere-DNA-mitochondria axis in telomerase-deficient mice

Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice

(2021) Dai Heng et al.   AGING CELL

Targeting the NLRP3 inflammasome in cardiovascular diseases

(2021) Stefano Toldo et al.   PHARMACOLOGY & THERAPEUTICS

Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential

(2020) Masomeh Maleki et al.   LIFE SCIENCES

Determinants of telomere length across human tissues

(2020) Kathryn Demanelis et al.   SCIENCE

Insights of tankyrases: A novel target for drug discovery

(2020) Manoj G. Damale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

(2019) Hisayuki Amano et al.   Cell Metabolism

N-3 Polyunsaturated Fatty Acids Decrease Long-Term Diabetic Risk of Offspring of Gestational Diabetes Rats by Postponing Shortening of Hepatic Telomeres and Modulating Liver Metabolism

(2019) Jinlong Gao et al.   Nutrients

Towards a unified mechanistic theory of aging

(2019) Gustavo Barja   EXPERIMENTAL GERONTOLOGY

Gender-Specific Beneficial Effects of Docosahexaenoic Acid Dietary Supplementation in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

(2019) Pascual Torres et al.   Neurotherapeutics

Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials

(2019) Serena Galiè et al.   Advances in Nutrition

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

(2018) Nunzia D'Onofrio et al.   ANTIOXIDANTS & REDOX SIGNALING

Gene pathways associated with mitochondrial function, oxidative stress and telomere length are differentially expressed in the liver of rats fed lifelong on virgin olive, sunflower or fish oils

(2018) Alfonso Varela-Lopez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis

(2018) Yanhua Kang et al.   Cell Reports

Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice

(2018) Iole Ferrara-Romeo et al.   PLoS One

Docosahexaenoic acid increases the expression of oxidative stress-induced growth inhibitor 1 through the PI3K/Akt/Nrf2 signaling pathway in breast cancer cells

(2017) Chia-Han Tsai et al.   FOOD AND CHEMICAL TOXICOLOGY

DNA damage related crosstalk between the nucleus and mitochondria

(2017) Mohammad Saki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microalgal Fatty Acids and Their Implication in Health and Disease

(2017) Lionel Ulmann et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells

(2017) Chiemi Sakai et al.   PLoS One

Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung

(2017) Sonia Navarro et al.   THORAX

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

(2016) Paula Martínez et al.   AGING CELL

P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan

(2016) Marco Giorgio et al.   AGING CELL

Mitochondrial Metabolism in Aging Heart

(2016) Edward J. Lesnefsky et al.   CIRCULATION RESEARCH

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence

(2016) Kazuo Yamagata et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

(2016) Artemis Simopoulos   Nutrients

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis

(2016) Jingnan Chen et al.   Oncotarget

Identification of cellular senescence-specific genes by comparative transcriptomics

(2016) Taiki Nagano et al.   Scientific Reports

PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases

(2015) Shiqin Xiong et al.   Cell Reports

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

(2014) Alexia Gómez et al.   AGING CELL

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

Multiplex time-reducing quantitative polymerase chain reaction assay for determination of telomere length in blood and tissue DNA

(2012) Jingjing Jiao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Telomeres and Mitochondria in the Aging Heart

(2012) Javid Moslehi et al.   CIRCULATION RESEARCH

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice

(2010) Naoki Makino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Telomere-Mediated Chromosomal Instability Triggers TLR4 Induced Inflammation and Death in Mice

(2010) Rabindra N. Bhattacharjee et al.   PLoS One