Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice

Telomere-driven diseases and telomere-targeting therapies

(2017) Paula Martínez et al.   JOURNAL OF CELL BIOLOGY

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

(2017) Geoffrey A. Preidis et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation

(2017) Latifa Bakiri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Histopathology of hepatocellular carcinoma

(2016) Manuel Schlageter et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Lineage fate of ductular reactions in liver injury and carcinogenesis

(2015) Simone Jörs et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic replicative stress induced by CCl4 in TRF1 knockout mice recapitulates the origin of large liver cell changes

(2015) Fabian Beier et al.   JOURNAL OF HEPATOLOGY

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway

(2015) Ning Zhang et al.   Oncotarget

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Cause-specific telomere factors deregulation in hepatocellular carcinoma

(2013) Manale El Idrissi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mouse models for liver cancer

(2013) Latifa Bakiri et al.   Molecular Oncology

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity

(2013) Frank Yeung et al.   Cell Reports

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

(2013) Paula Martínez et al.   Cell Reports

Primary hepatocellular carcinoma and metabolic syndrome: An update

(2013) Rubayat Rahman   World Journal of Gastrointestinal Oncology

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

(2012) Yoko Kidani et al.   IMMUNOLOGICAL REVIEWS

Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis

(2012) Yvonne Begus-Nahrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

PGC1  Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

(2011) K. Bhalla et al.   CANCER RESEARCH

Human telomeric proteins occupy selective interstitial sites

(2011) Dong Yang et al.   CELL RESEARCH

Constitutional telomerase mutations are genetic risk factors for cirrhosis

(2011) Rodrigo T. Calado et al.   HEPATOLOGY

Telomerase gene mutations are associated with cirrhosis formation

(2011) Daniel Hartmann et al.   HEPATOLOGY

Role of shelterin in cancer and aging

(2010) Paula Martínez et al.   AGING CELL

TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in Mice

(2010) Agueda M. Tejera et al.   DEVELOPMENTAL CELL

Alpha-fetoprotein-thymidine kinase–luciferase knockin mice: A novel model for dual modality longitudinal imaging of tumorigenesis in liver

(2010) Xincheng Lu et al.   JOURNAL OF HEPATOLOGY

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

(2010) Hsiangling Teo et al.   NATURE CELL BIOLOGY

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Metabolic syndrome and hepatocellular carcinoma

(2009) Abby B. Siegel et al.   CANCER

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

A Spectrum of Severe Familial Liver Disorders Associate with Telomerase Mutations

(2009) Rodrigo T. Calado et al.   PLoS One

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT