Eicosapentaenoic Acid Protects Against Metabolic Impairments in the APPswePS1dE9 Alzheimer's Disease Mouse Model

Uncoupling protein 1-independent effects of eicosapentaenoic acid in brown adipose tissue of diet-induced obese female mice

(2021) Emily K. Miller et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sex Differences in Early Programming by Maternal High Fat Diet Induced-Obesity and Fish Oil Supplementation in Mice

(2021) Latha Ramalingam et al.   Nutrients

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

(2020) Martí Colom-Cadena et al.   Alzheimers Research & Therapy

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease

(2020) Gurjit Kaur Bhatti et al.   Frontiers in Aging Neuroscience

Discordant Dose-Dependent Metabolic Effects of Eicosapentanoic Acid in Diet-Induced Obese Mice

(2020) Mandana Pahlavani et al.   Nutrients

High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

(2020) Oliver Bracko et al.   Scientific Reports

High-fat diet induced discrepant peripheral and central nervous systems insulin resistance in APPswe/PS1dE9 and wild-type C57BL/6J mice

(2020) Yujie Guo et al.   Aging-US

Can We Treat Neuroinflammation in Alzheimer’s Disease?

(2020) Sandra Sánchez-Sarasúa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease

(2019) Jing Zhi A. Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease

(2019) Leticia Forny-Germano et al.   Frontiers in Neuroscience

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

A high-sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice

(2019) Skye Hsin-Hsien Yeh et al.   NEUROBIOLOGY OF AGING

Sea Change for Marine Omega-3s

(2019) Evan L. O'Keefe et al.   MAYO CLINIC PROCEEDINGS

Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice

(2018) Paul Denver et al.   BRAIN BEHAVIOR AND IMMUNITY

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation

(2018) Yi-Heng Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Contributions of a high-fat diet to Alzheimer's disease-related decline: A longitudinal behavioural and structural neuroimaging study in mouse models

(2018) Colleen P.E. Rollins et al.   NeuroImage-Clinical

Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline

(2017) Lauren Macklin et al.   EXPERIMENTAL GERONTOLOGY

Short Aβ peptides attenuate Aβ42 toxicity in vivo

(2017) Brenda D. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes

(2017) Mandana Pahlavani et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

Food intake regulation by leptin: Mechanisms mediating gluconeogenesis and energy expenditure

(2017) Zulfia Hussain et al.   Asian Pacific Journal of Tropical Medicine

The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer’s Disease

(2017) Seden Demirci et al.   Clinical Psychopharmacology and Neuroscience

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology

(2016) Makoto Ishii et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults

(2016) Nadine Külzow et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

(2016) Roy Chun-Laam Ng et al.   Molecular Neurodegeneration

High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice

(2016) Peter Thériault et al.   Oncotarget

Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer’s Disease

(2015) Domenico Nuzzo et al.   Current Alzheimer Research

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system

(2015) Minji Kim et al.   Scientific Reports

Eicosapentaenoic Acid Reduces Adipocyte Hypertrophy and Inflammation in Diet-Induced Obese Mice in an Adiposity-Independent Manner

(2015) Monique J LeMieux et al.   JOURNAL OF NUTRITION

Omega-3 fatty acids’ effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial

(2014) Hadis Sabour et al.   JOURNAL OF SPINAL CORD MEDICINE

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system

(2013) Laura B. Buckman et al.   BRAIN BEHAVIOR AND IMMUNITY

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

(2013) Hennariikka Koivisto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Acute and sustained inflammation and metabolic dysfunction induced by high refined carbohydrate-containing diet in mice

(2013) Marina C. Oliveira et al.   Obesity

Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation

(2013) Heriberto Rodríguez-Hernández et al.   International Journal of Endocrinology

(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights

(2012) Nishan S. Kalupahana et al.   Advances in Nutrition

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance

(2011) Renee E. Stubbins et al.   EUROPEAN JOURNAL OF NUTRITION

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Increased Food Intake Leads to Obesity and Insulin Resistance in the Tg2576 Alzheimer’s Disease Mouse Model

(2010) Motoyuki Kohjima et al.   ENDOCRINOLOGY

Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation

(2010) Nishan S. Kalupahana et al.   JOURNAL OF NUTRITION

Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

(2009) Yanqiu Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association

(2009) Majid Fotuhi et al.   Nature Reviews Neurology

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Differential susceptibility to obesity between male, female and ovariectomized female mice

(2009) Jina Hong et al.   Nutrition Journal

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP × PS1 knock-in mice

(2008) Christa M. Studzinski et al.   JOURNAL OF NEUROCHEMISTRY

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING