The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease

Brain STAT5 signaling modulates learning and memory formation

(2018) Isadora C. Furigo et al.   Brain Structure & Function

Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway

(2018) Lina Ma et al.   EXPERIMENTAL GERONTOLOGY

Neuroanatomical differences in obesity: meta-analytic findings and their validation in an independent dataset

(2018) Isabel García-García et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin and adiponectin levels in major depressive disorder: A systematic review and meta-analysis

(2018) Bing Cao et al.   JOURNAL OF AFFECTIVE DISORDERS

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

(2018) Andre F Batista et al.   JOURNAL OF PATHOLOGY

Disruption of leptin signalling in a mouse model of Alzheimer’s disease

(2018) Anna King et al.   METABOLIC BRAIN DISEASE

The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer’s Disease

(2018) Gwangho Yoon et al.   MOLECULAR NEUROBIOLOGY

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

(2018) Fengjiao Sun et al.   MOLECULAR PSYCHIATRY

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Leptin and the maintenance of elevated body weight

(2018) Warren W. Pan et al.   NATURE REVIEWS NEUROSCIENCE

Leptin and brain–adipose crosstalks

(2018) Alexandre Caron et al.   NATURE REVIEWS NEUROSCIENCE

Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin

(2018) Gemma McGregor et al.   NEUROBIOLOGY OF AGING

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

(2018) Marcelo N.N. Vieira et al.   NEUROPHARMACOLOGY

Adiponectin modulates synaptic plasticity in hippocampal dentate gyrus

(2018) Farideh Pousti et al.   NEUROSCIENCE LETTERS

Association of adiponectin with cognitive function precedes overt diabetes in the Brazilian Longitudinal Study of Adult Health: ELSA

(2018) Adriana Cezaretto et al.   Diabetology & Metabolic Syndrome

Low Plasma Leptin and High Soluble Leptin Receptor Levels Are Associated With Mild Cognitive Impairment in Type 2 Diabetic Patients

(2018) Han Yin et al.   Frontiers in Aging Neuroscience

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

(2018) Francesca Romana Rizzo et al.   NEURAL PLASTICITY

The LepR-mediated leptin transport across brain barriers controls food reward

(2018) Alessandro Di Spiezio et al.   Molecular Metabolism

Body Mass Index in Mild Cognitive Impairment According to Age, Sex, Cognitive Intervention, and Hypertension and Risk of Progression to Alzheimer's Disease

(2018) Soo Hyun Joo et al.   Frontiers in Psychiatry

Metabolic syndrome and its effect on the brain: Possible mechanism

(2018) Nurul ‘Ain Arshad et al.   CNS & Neurological Disorders-Drug Targets

The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development

(2018) Fan Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leptin Induces Proliferation of Neuronal Progenitors and Neuroprotection in a Mouse Model of Alzheimer's Disease

(2018) Rocío Pérez-González et al.   JOURNAL OF ALZHEIMERS DISEASE

Adiposity and Cognitive Decline: Underlying Mechanisms

(2018) Deborah R. Gustafson   JOURNAL OF ALZHEIMERS DISEASE

Serum Adipokine Levels Modified by Donepezil Treatment in Alzheimer's Disease

(2018) Magdolna Pákáski et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered Serum Levels of Adipokines and Insulin in Probable Alzheimer's Disease

(2018) Vineet Kumar Khemka et al.   JOURNAL OF ALZHEIMERS DISEASE

2003-2013: A Decade of Body Mass Index, Alzheimer's Disease, and Dementia

(2018) Tim L. Emmerzaal et al.   JOURNAL OF ALZHEIMERS DISEASE

Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice

(2018) Lianhua Zhao et al.   Journal of Neuroinflammation

Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury

(2018) Qishuang Zhou et al.   JOURNAL OF NEUROTRAUMA

Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin

(2018) Pedro Cisternas et al.   MOLECULAR NEUROBIOLOGY

Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis

(2018) Kingshuk Pal et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Adiponectin is decreased in bipolar depression

(2018) Martina Platzer et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Rapid and reversible impairment of episodic memory by a high-fat diet in mice

(2018) Fiona H. McLean et al.   Scientific Reports

Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression

(2018) Sarah Nicolas et al.   Translational Psychiatry

Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses

(2017) Gemma McGregor et al.   FASEB JOURNAL

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease

(2017) Roy Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

(2017) W A Banks et al.   INTERNATIONAL JOURNAL OF OBESITY

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells

(2017) Mohamed Elfeky et al.   JOURNAL OF BIOCHEMISTRY

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

(2017) Gisele S. Seixas da Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin

(2017) Fernando Bartolome et al.   Journal of Neuroinflammation

Training Microglia to Resist Alzheimer's Disease

(2017) Marcelo N. N. Vieira et al.   JOURNAL OF NEUROSCIENCE

Late-life body mass index, rapid weight loss, apolipoprotein E ε4 and the risk of cognitive decline and incident dementia

(2017) S. P. Bell et al.   Journal of Nutrition Health & Aging

Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study

(2017) Priya Palta et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway

(2017) Zhi-Peng Xu et al.   NEUROCHEMICAL RESEARCH

Leptin Regulation of Synaptic Function at Hippocampal TA-CA1 and SC-CA1 Synapses: Implications for Health and Disease

(2017) Gemma McGregor et al.   NEUROCHEMICAL RESEARCH

Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later

(2017) Katarina Nägga et al.   NEUROLOGY

Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment

(2017) Mark A. Espeland et al.   NEUROLOGY

Globular Adiponectin Limits Microglia Pro-Inflammatory Phenotype through an AdipoR1/NF-κB Signaling Pathway

(2017) Sarah Nicolas et al.   Frontiers in Cellular Neuroscience

Adiponectin Regulates the Polarization and Function of Microglia via PPAR-γ Signaling Under Amyloid β Toxicity

(2017) Juhyun Song et al.   Frontiers in Cellular Neuroscience

Metformin in combination with rosiglitazone contribute to the increased serum adiponectin levels in people with type 2 diabetes mellitus

(2017) Jie-Ming Nie et al.   Experimental and Therapeutic Medicine

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?

(2017) Marcelo N. N. Vieira et al.   Frontiers in Aging Neuroscience

Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals

(2017) Prashanthi Vemuri et al.   JAMA Neurology

Adiponectin Receptors Are Less Sensitive to Stress in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Zoltán P. Várhelyi et al.   Frontiers in Neuroscience

Traumatic spinal cord injury

(2017) Christopher S. Ahuja et al.   Nature Reviews Disease Primers

Leptin Reduces Pathology and Improves Memory in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Steven J. Greco et al.   JOURNAL OF ALZHEIMERS DISEASE

Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer’s disease-like pathologies

(2017) Min Woo Kim et al.   Scientific Reports

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis

(2016) Chenxiao Liu et al.   CYTOKINE

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice

(2016) Di Zhang et al.   ENDOCRINOLOGY

Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice

(2016) Naotoshi Iwahara et al.   JOURNAL OF ALZHEIMERS DISEASE

Serum adiponectin levels are inversely correlated with leukemia: A meta-analysis

(2016) Jun-Jie Ma et al.   Journal of Cancer Research and Therapeutics

The long road to leptin

(2016) Jeffrey Friedman   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer’s like brain changes correlate with low adiponectin plasma levels in type 2 diabetic patients

(2016) Natalia García-Casares et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid  -Protein Oligomers

(2016) H. Xu et al.   JOURNAL OF NEUROSCIENCE

Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells

(2016) Mohamed Elfeky et al.   MEDIATORS OF INFLAMMATION

Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

(2016) Roy Chun-Laam Ng et al.   Molecular Neurodegeneration

Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors

(2016) D Zhang et al.   MOLECULAR PSYCHIATRY

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

(2016) S A Shah et al.   MOLECULAR PSYCHIATRY

C1q/Tumor Necrosis Factor-Related Protein-3 Attenuates Brain Injury after Intracerebral Hemorrhage via AMPK-Dependent Pathway in Rat

(2016) Shaohua Wang et al.   Frontiers in Cellular Neuroscience

Decline in Weight and Incident Mild Cognitive Impairment

(2016) Rabe E. Alhurani et al.   JAMA Neurology

Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding

(2016) Shigetomo Suyama et al.   Scientific Reports

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease

(2015) Alan King Lun Liu et al.   ACTA NEUROPATHOLOGICA

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior

(2015) Joëlle Chabry et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Adult neurogenic and antidepressant effects of adiponectin: a potential replacement for exercise?

(2015) Ang Li et al.   CNS & Neurological Disorders-Drug Targets

Leptin attenuates the detrimental effects of β-amyloid on spatial memory and hippocampal later-phase long term potentiation in rats

(2015) Jia-qing Tong et al.   HORMONES AND BEHAVIOR

Association of long-term dietary fat intake, exercise, and weight with later cognitive function in the Finnish Diabetes Prevention Study

(2015) Jenni Lehtisalo et al.   Journal of Nutrition Health & Aging

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

(2015) Hyeong-Kyu Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Plasma leptin levels and free leptin index in women with Alzheimer's disease

(2015) Agnieszka Baranowska-Bik et al.   NEUROPEPTIDES

IL-6 regulation of synaptic function in the CNS

(2015) Donna L. Gruol   NEUROPHARMACOLOGY

Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer’s disease brains and human microglia

(2015) D.G. Walker et al.   NEUROSCIENCE

Is there a “metabolic-mood syndrome”? A review of the relationship between obesity and mood disorders

(2015) Rodrigo B. Mansur et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation

(2015) K. C. G. de Git et al.   Obesity Reviews

Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin

(2015) Sarah Nicolas et al.   PSYCHONEUROENDOCRINOLOGY

Adipokines in health and disease

(2015) Mathias Fasshauer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Therapeutic window of globular adiponectin against cerebral ischemia in diabetic mice: the role of dynamic alteration of adiponectin/adiponectin receptor expression

(2015) Wenying Song et al.   Scientific Reports

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

(2015) Tahir Ali et al.   Scientific Reports

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease

(2015) Fernanda G. De Felice et al.   Frontiers in Aging Neuroscience

Overweight is not associated with cortical thickness alterations in children

(2015) Rachel J. Sharkey et al.   Frontiers in Neuroscience

Adiponectin as a Target in Obesity-related Inflammatory State

(2015) Koji Ohashi et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Plasma leptin levels are not predictive of dementia in patients with mild cognitive impairment

(2014) R. Oania et al.   AGE AND AGEING

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease

(2014) Silvia Maioli et al.   AGING CELL

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

(2014) Sergio T. Ferreira et al.   Alzheimers & Dementia

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential

(2014) Jane Johnston et al.   Current Alzheimer Research

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

(2014) Ying Liu et al.   DIABETES

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

Leptin gene therapy attenuates neuronal damages evoked by amyloid-β and rescues memory deficits in APP/PS1 mice

(2014) R Pérez-González et al.   GENE THERAPY

20 YEARS OF LEPTIN: Leptin and reproduction: past milestones, present undertakings, and future endeavors

(2014) Farid F Chehab   JOURNAL OF ENDOCRINOLOGY

20 YEARS OF LEPTIN: Connecting leptin signaling to biological function

(2014) Margaret B Allison et al.   JOURNAL OF ENDOCRINOLOGY

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Adipokines: a link between obesity and dementia?

(2014) Amanda J Kiliaan et al.   LANCET NEUROLOGY

Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice Through Adiponectin Receptor 1-Mediated Phosphorylation of GSK-3β

(2014) Fan Guo et al.   MOLECULAR NEUROBIOLOGY

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

(2014) S. Y. Yau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Adiponectin and its Receptors in the Porcine Hypothalamus During the Oestrous Cycle

(2014) T Kaminski et al.   REPRODUCTION IN DOMESTIC ANIMALS

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

(2014) Jiyoon Ryu et al.   Cell Reports

Raised Serum Proinflammatory Cytokines in Alzheimer's Disease with Depression

(2014)   Aging and Disease

Obesity and cognitive decline: role of inflammation and vascular changes

(2014) Jason C. D. Nguyen et al.   Frontiers in Neuroscience

Reduced cortical thickness associated with visceral fat and BMI

(2014) Ralf Veit et al.   NeuroImage-Clinical

Regulation of adiponectin multimerization, signaling and function

(2013) Meilian Liu et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

(2013) Byung-Cheol Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Does obesity predict bipolarity in major depressive patients?

(2013) Giulia Vannucchi et al.   JOURNAL OF AFFECTIVE DISORDERS

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

(2013) David J. Bonda et al.   JOURNAL OF NEUROCHEMISTRY

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort

(2013) V. Gallo et al.   NEUROLOGY

Globular adiponectin elicits neuroprotection by inhibiting NADPH oxidase-mediated oxidative damage in ischemic stroke

(2013) W. Song et al.   NEUROSCIENCE

Leptin regulation of hippocampal synaptic function in health and disease

(2013) A. J. Irving et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Frontal cortical thinning and subcortical volume reductions in early adulthood obesity

(2013) Idoia Marqués-Iturria et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

Leptin and dementia over 32 years—The Prospective Population Study of Women

(2012) Deborah R. Gustafson et al.   Alzheimers & Dementia

Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease

(2012) Thomas M. van Himbergen   ARCHIVES OF NEUROLOGY

Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6

(2012) T.E. Nelson et al.   BRAIN BEHAVIOR AND IMMUNITY

Challenges and Opportunities of Defining Clinical Leptin Resistance

(2012) Martin G. Myers et al.   Cell Metabolism

Energy Balance and Obesity

(2012) James O. Hill et al.   CIRCULATION

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

A Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US Cohorts

(2012) Ying Bao et al.   JNCI-Journal of the National Cancer Institute

Diabetes and cognitive dysfunction

(2012) Rory J McCrimmon et al.   LANCET

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β

(2012) Gayle H. Doherty et al.   NEUROBIOLOGY OF AGING

Decreased Levels of Circulating Adiponectin in Mild Cognitive Impairment and Alzheimer’s Disease

(2012) Antonio L. Teixeira et al.   NEUROMOLECULAR MEDICINE

Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

(2012) Koon-Ho Chan et al.   PLoS One

The Emerging Roles of Adiponectin in Female Reproductive System-Associated Disorders and Pregnancy

(2012) George Angelidis et al.   Reproductive Sciences

Cardiovascular disease risk in healthy children and its association with body mass index: systematic review and meta-analysis

(2012) C. Friedemann et al.   BMJ-British Medical Journal

Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells

(2011) Christa M. Patterson et al.   BRAIN RESEARCH

Adiponectin receptor signalling in the brain

(2011) John Thundyil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Leptin receptor signaling: pathways to leptin resistance

(2011) Joris Wauman   Frontiers in Bioscience-Landmark

Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study

(2011) S Yokum et al.   INTERNATIONAL JOURNAL OF OBESITY

Interaction Between Body Mass Index and Central Adiposity and Risk of Incident Cognitive Impairment and Dementia: Results from the Women's Health Initiative Memory Study

(2011) Diana R. Kerwin et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes

(2011) Stefan Lehr et al.   MOLECULAR & CELLULAR PROTEOMICS

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

(2011) Sabrina Paganoni et al.   MUSCLE & NERVE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Evolution of Leptin Structure and Function

(2011) Robert J. Denver et al.   NEUROENDOCRINOLOGY

Midlife overweight and obesity increase late-life dementia risk: A population-based twin study

(2011) W. L. Xu et al.   NEUROLOGY

NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity

(2011) Peter R. Moult et al.   NEUROPHARMACOLOGY

Adipocytokines and CD34+ Progenitor Cells in Alzheimer's Disease

(2011) Boris Bigalke et al.   PLoS One

Plasma adiponectin elevation in elderly individuals with subsyndromal depression

(2011) Hyun-Ghang Jeong et al.   PSYCHONEUROENDOCRINOLOGY

Adiponectin protects rat hippocampal neurons against excitotoxicity

(2010) Guang Qiu et al.   AGE

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Overweight, Obesity, and Depression

(2010) Floriana S. Luppino et al.   ARCHIVES OF GENERAL PSYCHIATRY

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Neurodevelopmental actions of leptin

(2010) Sebastien G. Bouret   BRAIN RESEARCH

Abdominal Fat, Adipose-Derived Hormones and Mild Cognitive Impairment: The J-SHIPP Study

(2010) Kenji Kamogawa et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer’s disease

(2010) K. Une et al.   EUROPEAN JOURNAL OF NEUROLOGY

The procognitive effects of leptin in the brain and their clinical implications

(2010) G. Paz-Filho et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-β Oligomers

(2010) Sofia Jürgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway

(2010) Gurdeep Marwarha et al.   JOURNAL OF NEUROCHEMISTRY

Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition

(2010) P. R. Moult et al.   JOURNAL OF NEUROSCIENCE

Accelerated Weight Loss and Incident Dementia in an Elderly African-American Cohort

(2010) Sujuan Gao et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Regulation of glutamate receptor trafficking by leptin

(2009) Peter R. Moult et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Adiponectin protects against cerebral ischemia–reperfusion injury through anti-inflammatory action

(2009) Bi Chen et al.   BRAIN RESEARCH

Adiponectin protects hippocampal neurons against kainic acid-induced excitotoxicity

(2009) Byeong Tak Jeon et al.   BRAIN RESEARCH REVIEWS

Brain structure and obesity

(2009) Cyrus A. Raji et al.   HUMAN BRAIN MAPPING

Overweight in midlife and risk of dementia: a 40-year follow-up study

(2009) L B Hassing et al.   INTERNATIONAL JOURNAL OF OBESITY

Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

(2009) Wolfgang Lieb   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity and Onset of Significant Depressive Symptoms

(2009) Nicole Vogelzangs et al.   JOURNAL OF CLINICAL PSYCHIATRY

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Adiponectin: from obesity to cardiovascular disease

(2009) C. Antoniades et al.   Obesity Reviews

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

(2008) Christy L. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells

(2008) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Post-translational modifications of adiponectin: mechanisms and functional implications

(2008) Yu Wang et al.   BIOCHEMICAL JOURNAL

The Adiponectin Receptors AdipoR1 and AdipoR2 Activate ERK1/2 through a Src/Ras-Dependent Pathway and Stimulate Cell Growth†

(2008) Mi-Hye Lee et al.   BIOCHEMISTRY

AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus

(2008) Andressa Coope et al.   FEBS LETTERS

Leptin Increases Adult Hippocampal Neurogenesisin Vivoandin Vitro

(2008) Jacob C. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression

(2008) Bysani Chandrasekar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin reverses long-term potentiation at hippocampal CA1 synapses

(2008) Peter R. Moult et al.   JOURNAL OF NEUROCHEMISTRY

Associations of obesity with psychiatric disorders and suicidal behaviors in a nationally representative sample

(2008) Amber A. Mather et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

(2008) Karen F. Holden et al.   NEUROBIOLOGY OF AGING

Expression of Adiponectin and Adiponectin Receptors in Human Pituitary Gland and Brain

(2008) Aristea Psilopanagioti et al.   NEUROENDOCRINOLOGY

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Mechanisms of Leptin Action and Leptin Resistance

(2007) Martin G. Myers et al.   Annual Review of Physiology

Leptin inhibits 4-aminopyridine– and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents

(2007) Lin Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Megalin mediates the transport of leptin across the blood-CSF barrier

(2007) Marcelo O. Dietrich et al.   NEUROBIOLOGY OF AGING