Inner workings of RAG recombinase and its specialization for adaptive immunity

Cutting antiparallel DNA strands in a single active site

(2020) Xuemin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How mouse RAG recombinase avoids DNA transposition

(2020) Xuemin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of seamless excision and specific targeting by piggyBac transposase

(2020) Qiujia Chen et al.   Nature Communications

Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase

(2020) Yuhang Zhang et al.   EMBO JOURNAL

Transposon molecular domestication and the evolution of the RAG recombinase

(2019) Yuhang Zhang et al.   NATURE

Structures of a RAG-like transposase during cut-and-paste transposition

(2019) Chang Liu et al.   NATURE

Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts

(2019) George E. Ghanim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Jump ahead with a twist: DNA acrobatics drive transposition forward

(2019) Vladimir Arinkin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance

(2018) Anna Rubio-Cosials et al.   CELL

Cracking the DNA Code for V(D)J Recombination

(2018) Min-Sung Kim et al.   MOLECULAR CELL

DNA melting initiates the RAG catalytic pathway

(2018) Heng Ru et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination

(2016) Shengfeng Huang et al.   CELL

Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon

(2015) Vladimir V Kapitonov et al.   Biology Direct

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

(2015) Heng Ru et al.   CELL

Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end Complexes

(2015) Mikalai Lapkouski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

The Mu transpososome structure sheds light on DDE recombinase evolution

(2012) Sherwin P. Montaño et al.   NATURE

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Moving DNA around: DNA transposition and retroviral integration

(2011) Sherwin P Montaño et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The mechanism of retroviral integration from X-ray structures of its key intermediates

(2010) Goedele N. Maertens et al.   NATURE

Bias between the Left and Right Inverted Repeats during IS911 Targeted Insertion

(2008) P. Rousseau et al.   JOURNAL OF BACTERIOLOGY