Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

(2022) Julia TCW et al.   CELL

APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation

(2022) Laurie Arnaud et al.   Cell Reports

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice

(2022) Isha Mhatre-Winters et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation

(2021) Maria Fe Lanfranco et al.   GLIA

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Physiological and Pathological Ageing of Astrocytes in the Human Brain

(2021) Marloes Verkerke et al.   NEUROCHEMICAL RESEARCH

Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

(2021) Pranav Preman et al.   Cells

Isoform-dependent APOE secretion modulates neuroinflammation

(2021) Philip Hasel et al.   Nature Reviews Neurology

Neuroinflammatory astrocyte subtypes in the mouse brain

(2021) Philip Hasel et al.   NATURE NEUROSCIENCE

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

(2021) Se-In Lee et al.   Stem Cell Reports

APOE in the normal brain

(2020) Sarah A. Flowers et al.   NEUROBIOLOGY OF DISEASE

Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice

(2020) Yuan Shang et al.   PLoS One

Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

(2020) Na Zhao et al.   NEURON

APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

(2020) Elles Konijnenberg et al.   Alzheimers Research & Therapy

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

(2020) He-Yang Zhang et al.   Journal of Neuroinflammation

Astrocyte Crosstalk in CNS Inflammation

(2020) Mathias Linnerbauer et al.   NEURON

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components

(2019) Yu Yamazaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

(2019) Matthew L. Neal et al.   FASEB JOURNAL

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts

(2018) Rachel F. Buckley et al.   Alzheimers & Dementia

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

(2018) Matthew L. Neal et al.   Journal of Neuroinflammation

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

Cell Densities in the Mouse Brain: A Systematic Review

(2018) Daniel Keller et al.   Frontiers in Neuroanatomy

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

(2018) Jingting Dai et al.   Frontiers in Molecular Neuroscience

The sex differences of the behavior response to early Life immune stimulation: Microglia and astrocytes involvement

(2018) I. Berkiks et al.   PHYSIOLOGY & BEHAVIOR

Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network

(2018) Aurélie Bussy et al.   NEUROBIOLOGY OF AGING

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

ApoE isoforms differentially regulates cleavage and secretion of BDNF

(2017) Abhik Sen et al.   Molecular Brain

Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke

(2017) Tian Ming Tu et al.   Annals of Clinical and Translational Neurology

Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model

(2017) Daniel T. Laskowitz et al.   Scientific Reports

Sex differences in the association between AD biomarkers and cognitive decline

(2016) Mary Ellen I. Koran et al.   Brain Imaging and Behavior

Apolipoprotein E metabolism and functions in brain and its role in Alzheimerʼs disease

(2016) Fan Liao et al.   CURRENT OPINION IN LIPIDOLOGY

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Astrocitos en las enfermedades neurodegenerativas (I): función y caracterización molecular

(2015) T. Guillamón-Vivancos et al.   NEUROLOGIA

Elusive roles for reactive astrocytes in neurodegenerative diseases

(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Implications of glial nitric oxide in neurodegenerative diseases

(2015) Jose Enrique Yuste et al.   Frontiers in Cellular Neuroscience

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Apolipoprotein E in Alzheimer's Disease: An Update

(2014) Jin-Tai Yu et al.   Annual Review of Neuroscience

APOEgenotype-dependent modulation of astrocyte chemokine CCL3 production

(2014) Eiron Cudaback et al.   GLIA

The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution

(2014) Suzana Herculano-Houzel   GLIA

APOε4 is associated with enhanced in vivo innate immune responses in human subjects

(2014) Stephen C. Gale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

(2014) Gustavo A Rodriguez et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Heterogeneity of reactive astrocytes

(2013) Mark A. Anderson et al.   NEUROSCIENCE LETTERS

APOE genotype alters glial activation and loss of synaptic markers in mice

(2012) Yuangui Zhu et al.   GLIA

Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation

(2012) Eiron Cudaback et al.   Journal of Neuroinflammation

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide

(2011) María Santos-Galindo et al.   Biology of Sex Differences

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans

(2010) Xue Hua et al.   NEUROBIOLOGY OF AGING

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

ApoE4-dependent Aβ-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum

(2009) Haim Belinson et al.   JOURNAL OF NEURAL TRANSMISSION

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Genome-Wide Association Studies in Alzheimer Disease

(2008) Stephen C. Waring et al.   ARCHIVES OF NEUROLOGY

A method for gender determination in newborn dark pigmented mice

(2008) Inge G. Wolterink-Donselaar et al.   LAB ANIMAL

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING