The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex

(2018) Marianna Stamou et al.   Journal of Neuroinflammation

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide

(2017) Eric E. Beier et al.   NEUROBIOLOGY OF DISEASE

Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson’s disease on chromosome 7p15.3

(2017) Megha N. Murthy et al.   NEUROGENETICS

Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss

(2017) Gelareh Alam et al.   NEUROTOXICOLOGY

Macrophage-Associated Osteoactivin/GPNMB Mediates Mesenchymal Stem Cell Survival, Proliferation, and Migration Via a CD44-Dependent Mechanism

(2016) Bing Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

GPNMB ameliorates mutant TDP-43-induced motor neuron cell death

(2016) Yuki Nagahara et al.   JOURNAL OF NEUROSCIENCE RESEARCH

No association of GPNMB rs156429 polymorphism with Parkinson’s disease, amyotrophic lateral sclerosis and multiple system atrophy in Chinese population

(2016) YaQian Xu et al.   NEUROSCIENCE LETTERS

Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase

(2016) Yoko Ono et al.   Scientific Reports

Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93Amouse model of amyotrophic lateral sclerosis

(2015) Yuki Nagahara et al.   JOURNAL OF NEUROSCIENCE RESEARCH

GPNMB cooperates with neuropilin-1 to promote mammary tumor growth and engages integrin α5β1 for efficient breast cancer metastasis

(2015) G Maric et al.   ONCOGENE

Astrocytes in Neurodegenerative Disease: Table 1.

(2015) Hemali Phatnani et al.   Cold Spring Harbor Perspectives in Biology

Osteoactivin Promotes Osteoblast Adhesion Through HSPG and αvβ1 Integrin

(2014) Fouad M. Moussa et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CD44 Suppresses TLR-Mediated Inflammation

(2014) H. Kawana et al.   JOURNAL OF IMMUNOLOGY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia–reperfusion injury

(2014) Y. Nakano et al.   NEUROSCIENCE

Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions

(2014) Stefan Schildknecht   ALTEX-Alternatives to Animal Experimentation

Expression of integrin and CD44 receptors recognising osteopontin in the normal and LPS-lesioned rat substantia nigra

(2013) Sara Ailane et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: Potential role for tissue engineering bone

(2013) Xuefeng Hu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Multiple Roles for Astrocytes as Effectors of Cytokines and Inflammatory Mediators

(2013) Michael V. Sofroniew   NEUROSCIENTIST

Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation

(2013) Muhammad M. Hossain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model

(2012) Tomohiro Matsumoto et al.   NEUROSCIENCE LETTERS

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis

(2012) Hirotaka Tanaka et al.   Scientific Reports

Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats

(2012) Jian-Jun Huang et al.   Brain and Behavior

CD44-Positive Cells Are Candidates for Astrocyte Precursor Cells in Developing Mouse Cerebellum

(2011) Na Cai et al.   CEREBELLUM

A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

(2011) et al.   PLoS Genetics

A simple magnetic separation method for high-yield isolation of pure primary microglia

(2010) Richard Gordon et al.   JOURNAL OF NEUROSCIENCE METHODS

Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function

(2008) S ABDELMAGID et al.   EXPERIMENTAL CELL RESEARCH

Microglial cells and Parkinson’s disease

(2008) Li Qian et al.   IMMUNOLOGIC RESEARCH

The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains

(2008) Y YASUDA et al.   JOURNAL OF NEUROIMMUNOLOGY

Distinct mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine resistance revealed by transcriptome mapping in mouse striatum

(2008) R. Pattarini et al.   NEUROSCIENCE