ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

(2019) Yu Yamazaki et al.   BRAIN

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

TMEM106B haplotypes have distinct gene expression patterns in aged brain

(2018) Yingxue Ren et al.   Molecular Neurodegeneration

Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

(2018) Kenzo Koizumi et al.   Nature Communications

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

(2017) Angeliki Maria Nikolakopoulou et al.   PLoS One

APOE2eases cognitive decline during Aging: Clinical and preclinical evaluations

(2016) Mitsuru Shinohara et al.   ANNALS OF NEUROLOGY

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

The effects of the apoE4 genotype on the developing mouse retina

(2016) Idit Maharshak et al.   EXPERIMENTAL EYE RESEARCH

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association

(2015) M. Simons et al.   CIRCULATION RESEARCH

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway

(2015) Caroline S. Casey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regional and Stage-Specific Effects of Prospectively Purified Vascular Cells on the Adult V-SVZ Neural Stem Cell Lineage

(2015) E. E. Crouch et al.   JOURNAL OF NEUROSCIENCE

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

(2014) Alan W. J. Morris et al.   Frontiers in Aging Neuroscience

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Laminin isoforms in endothelial and perivascular basement membranes

(2013) Lema F. Yousif et al.   Cell Adhesion & Migration

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

Isolation and Culture of Mouse Cortical Astrocytes

(2013) Sebastian Schildge et al.   Jove-Journal of Visualized Experiments

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Serum tight-junction proteins predict hemorrhagic transformation in ischemic stroke patients

(2012) R. Kazmierski et al.   NEUROLOGY

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice

(2010) Manuel Buttini et al.   AMERICAN JOURNAL OF PATHOLOGY

TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

(2010) C. A. Aveleira et al.   DIABETES

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

(2009) A. N. Stratman et al.   BLOOD

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON