Proteoglycans: a common portal for SARS-CoV-2 and extracellular vesicle uptake

Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization

(2022) Valeria Governa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity

(2022) Rana El Masri et al.   Cell Reports

The matricellular protein thrombospondin-1 in lung inflammation and injury

(2022) Mohammadreza Tabary et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Matrix Proteoglycans in Tumor Inflammation and Immunity

(2022) Gauri Deb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SARS‐CoV ‐2 spike protein enhances MAP4K3 / GLK ‐induced ACE2 stability in COVID ‐19

(2022) Huai‐Chia Chuang et al.   EMBO Molecular Medicine

Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer

(2022) Nader Al-Nakouzi et al.   Nature Communications

Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants

(2022) Adrianne L. Gelbach et al.   Frontiers in Molecular Biosciences

The role of the glypican and syndecan families of heparan sulfate proteoglycans in cardiovascular function and disease

(2022) Lakshmi Narasimha Rao Thota et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Spike-heparan sulfate interactions in SARS-CoV-2 infection

(2022) Fiona L. Kearns et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis

(2022) Zhongyun Zhang et al.   Frontiers in Public Health

Phagocytosis: Sweet Repulsions via the Glycocalyx

(2021) Sophia Maschalidi et al.   CURRENT BIOLOGY

Leveraging systems biology for predicting modulators of inflammation in patients with COVID-19

(2021) Sascha Jung et al.   Science Advances

Contribution of Syndecans to the Cellular Entry of SARS-CoV-2

(2021) Anett Hudák et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SARS-CoV-2 cell tropism and multiorgan infection

(2021) Jia Liu et al.   Cell Discovery

Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans

(2021) Marta Bermejo‐Jambrina et al.   EMBO JOURNAL

APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans

(2021) Dimitrios Tsiantoulas et al.   NATURE

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

(2021) Maritza Puray-Chavez et al.   Cell Reports

Mechanisms of SARS-CoV-2 entry into cells

(2021) Cody B. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

(2020) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans

(2020) Melanie Koehler et al.   Annual Review of Virology

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

(2020) Jennifer A. Aguiar et al.   EUROPEAN RESPIRATORY JOURNAL

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo

(2020) Gabriela Arias-Alpizar et al.   Nature Communications

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

(2020) So Young Kim et al.   ANTIVIRAL RESEARCH

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

An Acquired and Endogenous Glycocalyx Forms a Bidirectional “Don’t Eat” and “Don’t Eat Me” Barrier to Phagocytosis

(2020) Paul R.C. Imbert et al.   CURRENT BIOLOGY

Hypoxic induction of exosome uptake through proteoglycan dependent endocytosis fuels the lipid droplet phenotype in glioma

(2020) Myriam Cerezo-Magana et al.   MOLECULAR CANCER RESEARCH

Upregulated Na+/H+-Exchange Protects Human Colon Cancer Tissue against Intracellular Acidification

(2019) Ninna C. S. Voss et al.   Biomed Research International

Ultrasensitive immunoprofiling of plasma extracellular vesicles identifies syndecan-1 as a potential tool for minimally invasive diagnosis of glioma

(2019) Vineesh Indira Chandran et al.   CLINICAL CANCER RESEARCH

Pro-metastatic functions of lipoproteins and extracellular vesicles in the acidic tumor microenvironment

(2019) Anna Bång-Rudenstam et al.   CANCER AND METASTASIS REVIEWS

The pleiotropic role of proteoglycans in extracellular vesicle mediated communication in the tumor microenvironment

(2019) M. Cerezo-Magaña et al.   SEMINARS IN CANCER BIOLOGY

Chondroitin sulfate content and decorin expression in glioblastoma are associated with proliferative activity of glioma cells and disease prognosis

(2019) Alexandra Y. Tsidulko et al.   CELL AND TISSUE RESEARCH

Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics

(2019) Vineesh Indira Chandran et al.   JOURNAL OF NEURO-ONCOLOGY

Glycobiology of syndecan-1 in bacterial infections

(2018) Rafael S. Aquino et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling

(2018) Wen-Chieh Liao et al.   PLoS One

Proteoglycans—Biomarkers and Targets in Cancer Therapy

(2018) Dragana Nikitovic et al.   Frontiers in Endocrinology

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

(2018) Zaira Boussadia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Humanized chondroitinase ABC sensitizes glioblastoma cells to temozolomide

(2017) Alena Cristina Jaime-Ramirez et al.   JOURNAL OF GENE MEDICINE

Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment

(2017) Julien A. Menard et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

(2017) Katharine A. White et al.   Science Signaling

Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity

(2017) Helena C. Christianson et al.   Oncotarget

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

(2017) Katharine A. White et al.   Science Signaling

Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells

(2017) E L Kavanagh et al.   Oncogenesis

Prominent features of the amino acid mutation landscape in cancer

(2017) Zachary A. Szpiech et al.   PLoS One

Heparan Sulfate in the Developing, Healthy, and Injured Lung

(2016) Sarah M. Haeger et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Exploring preferred amino acid mutations in cancer genes: Applications to identify potential drug targets

(2016) P. Anoosha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

(2016) J. A. Menard et al.   CANCER RESEARCH

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

(2015) Ali Salanti et al.   CANCER CELL

Changes in composition and sulfation patterns of glycoaminoglycans in renal cell carcinoma

(2015) Ebru Ucakturk et al.   GLYCOCONJUGATE JOURNAL

Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2

(2015) Olivier G. de Jong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity

(2015) Hua Tan et al.   Scientific Reports

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

Pan-Cancer Analysis of Mutation Hotspots in Protein Domains

(2015) Martin L. Miller et al.   Cell Systems

Host Matrix Modulation by Tumor Exosomes Promotes Motility and Invasiveness

(2015) Wei Mu et al.   NEOPLASIA

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Three-dimensional constructs using hyaluronan cell carrier as a tool for the study of cancer stem cells

(2014) Cristina Martínez-Ramos et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosaminoglycans in cancer treatment

(2014) Mattias Belting   THROMBOSIS RESEARCH

Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer

(2014) Romain R. Vivès et al.   Frontiers in Oncology

Cooperative Heparin-Mediated Oligomerization of Fibroblast Growth Factor-1 (FGF1) Precedes Recruitment of FGFR2 to Ternary Complexes

(2013) Alan Brown et al.   BIOPHYSICAL JOURNAL

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

(2012) Andrew Koo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamous Cell Carcinoma

(2012) M. A. Thelin et al.   CANCER RESEARCH

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Decorin–TGFβ Axis in Hepatic Fibrosis and Cirrhosis

(2012) Kornélia Baghy et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Chondroitin sulfate expression predicts poor outcome in breast cancer

(2011) Mattias Belting   INTERNATIONAL JOURNAL OF ONCOLOGY

Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery

(2010) A. Wittrup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ScFv Antibody-induced Translocation of Cell-surface Heparan Sulfate Proteoglycan to Endocytic Vesicles

(2009) Anders Wittrup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice

(2009) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostatic chondroitin sulfate is increased in patients with metastatic disease but does not predict survival outcome

(2009) Carmela Ricciardelli et al.   PROSTATE