Article
Cell Biology
Hanlin Ma, Fang Han, Xiaohui Yan, Gonghua Qi, Yingwei Li, Rongrong Li, Shi Yan, Cunzhong Yuan, Kun Song, Beihua Kong
Summary: Cervical cancer is the fourth most common cancer in women globally, and the overexpression of PBK in cervical cancer tissues promotes proliferation, metastasis, and cisplatin resistance of cancer cells through the ERK/c-Myc signaling pathway. Inhibition of PBK with OTS514 shows promising results in suppressing tumor growth and enhancing chemosensitivity. Further studies on PBK as a molecular target for cervical cancer treatment are warranted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yeon Sun Kim, Jia Yuan, Amanda Dewar, Jean-Paul Borg, David W. Threadgill, Xiaofei Sun, Sudhansu K. Dey
Summary: HB-EGF recruits VANGL2 for tyrosine phosphorylation through binding to ERBB2 and ERBB3, thereby influencing uterine epithelial cell polarity and regulating the implantation process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Yang Jiang, Junshuang Zhao, Yingliang Liu, Juntao Hu, Liang Gao, Hui Wang, Daming Cui
Summary: Glioma stem cells (GSCs) are a special kind of cells in GBM showing tumor initiation, self-renewal, and multi-lineage differentiation abilities. Finding novel circRNAs related to GSCs is of great significance for the study of glioma. Our study found that circKPNB1 is a novel oncogene in GBM and has great significance in the diagnosis and prognosis prediction of GBM.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Zhengzheng Xiao, Xiaoli Yang, Zebin Liu, Zheng Shao, Chaojun Song, Kun Zhang, Xiaobin Wang, Zhengwei Li
Summary: This study investigated the role of GASC1 in glioma progression and found that GASC1 enhances NOTCH signaling to promote glioma progression. Inhibition of GASC1 and NOTCH1 showed potential as therapeutic targets for treating glioma.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Liu, Conghui Li, Jiao Li, Lesi Xie, Zeng Hong, Kang Zheng, Xiaofeng Zhao, Aifen Yang, Xiaofeng Xu, Huaping Tao, Mengsheng Qiu, Junlin Yang
Summary: This study demonstrates that EGF facilitates the transdifferentiation of astrocytes to oligodendrocytes, and suggests that targeting the EGF-EGFR-Erk1/2 signaling axis may represent a novel therapeutic strategy for myelin repair in injured central nervous system (CNS) tissues.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Jung-Chien Cheng, Xiaoyu Han, Qingxue Meng, Yanjie Guo, Boqun Liu, Tinglin Song, Yuanyuan Jia, Lanlan Fang, Ying-Pu Sun
Summary: This study reveals that HB-EGF can enhance the luteal function in humans by inducing StAR expression and progesterone production through the activation of the ERK1/2 signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Kai Wang, Yanhua Qi, Xu Wang, Yushuai Liu, Min Zhao, Ding Zhou, Yu Zhang, Yan Wang, Rutong Yu, Xiuping Zhou
Summary: This study revealed that GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy, and inhibiting autophagy may benefit glioma patients with high levels of GOLPH3. The novel GOLPH3-PHB2-autophagy axis may serve as a potential and promising therapeutic target for gliomas.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Fan Feng, Zongqing Zhao, Xuechang Cai, Xueyuan Heng, Ximeng Ma
Summary: This study identifies CKS2 as a critical contributor to the development of gliomas, suggesting that it may serve as a novel therapeutic target for inhibiting the spread and infiltration of glioma.
Article
Cell Biology
Yongguang Yang, Marissa Leonard, Zhenhua Luo, Syn Yeo, Gregory Bick, Mingang Hao, Chunmiao Cai, Mahmoud Charif, Jiang Wang, Jun-Lin Guan, Elyse E. Lower, Xiaoting Zhang
Summary: The study reveals the crucial role of MED1 in HER2-driven mammary tumorigenesis, showing that its overexpression can significantly promote the onset, growth, metastasis, and multiplicity of HER2 tumors. Further investigations demonstrate that MED1 is involved in epithelial-mesenchymal transition, cancer stem cell formation, and response to anti-HER2 therapy. Additionally, the research identifies Jab1 as the key target gene of MED1 contributing to these processes and shows a reciprocal regulation between Jab1 and MED1.
Article
Immunology
Min Chao, Nan Liu, Zhichuan Sun, Yongli Jiang, Tongtong Jiang, Meng Xv, Lintao Jia, Yanyang Tu, Liang Wang
Summary: Sox9, an upregulated transcription factor in clinical gliomas associated with poor prognosis, promotes migration and invasion of glioma cells and in vivo tumor development. It functions downstream of the TGF-beta pathway, where TGF-beta signaling prevents proteasomal degradation of Sox9 protein in glioma cells. These findings provide new insights into the interaction between TGF-beta signaling and oncogenic transcription factors, with implications for targeted therapy and prognostic assessment of gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yousef Salama, Nidal Jaradat, Koichi Hattori, Beate Heissig
Summary: ALOC-EO has an anti-tumor effect on melanoma growth and tumor cell migration by blocking EGFR and ERK1/2 signaling pathways, enhancing its efficacy as a monotherapy or in combination with myelosuppressive drugs in melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Joana F. da Rocha, Luisa Bastos, Sara C. Domingues, Ana R. Bento, Uwe Konietzko, Odete A. B. da Cruz e Silva, Sandra I. Vieira
Summary: The study revealed that the APP protein interacts with HB-EGF and EGF EGFR ligands, affecting ERK activation and neurite outgrowth. The interaction between APP and HB-EGF was confirmed, with implications for ERK pathway activation and neuronal differentiation. The synergistic effect of EGF and APP on neuritogenesis was shown to involve the EGFR pathway and has potential implications for Alzheimer's disease and adult neuroregeneration.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Zeyu Wu, Peng Lun, Tao Ji, Jiaojiao Niu, Xiuyan Sun, Xia Liu, Jian Xu
Summary: This study demonstrates that SNHG25 is upregulated in glioma cells and tissues, and its knockdown inhibits glioma cell proliferation and tumor growth. SNHG25 positively regulates MAPK signaling through sponging miR-579-5p and activating MAP2K2. Therefore, SNHG25 may serve as a potential target and biomarker for glioma.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Oncology
Qi Lin, Zhen Chen, Zhao-Li Shen, Fei Xue, Jia-Jun Qin, Xi-Peng Kang, Zhong-Rong Chen, Zhong -Yuan Xia, Liang Gao, Xian-Zhen Chen
Summary: TRAF3IP3 is associated with poor prognosis in glioma patients and promotes tumor growth, migration, and invasion by activating the ERK signaling pathway. These findings suggest that TRAF3IP3 could serve as a potential biomarker for glioma prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jinjun Shi, Chenchun Fu, Xiangyu Su, Shicheng Feng, Sheng Wang
Summary: The study shows that ultrasound-stimulated microbubbles have potential in improving drug delivery efficiency and treating esophageal squamous cell carcinoma, significantly affecting cell survival, proliferation, migration, invasion, and apoptosis. In addition, USMBs therapy further enhances the inhibitory effect of radiotherapy on ESCC cells by inhibiting angiogenesis.
Article
Pharmacology & Pharmacy
Chiung-Hui Liu, Wen-Chieh Liao, Hsin-Hua Li, Li-Ho Tseng, Wei-Han Wang, Hsin Tung, Pin-Jiun Lin, Hsin-Tung Jao, Wen-Yuan Liu, Ching-Sui Hung, Chih-Li Lin, Ying-Jui Ho
Summary: The combination therapy of clavulanic acid and valproic acid showed synergistic effects in the experimental epilepsy rat model, improving behavioral and neuronal deficits. This combination treatment has potential practicality in seizure suppression and may have therapeutic effects on epilepsy and related neuronal damage.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Yea-Tzy Chen, Li-You Chen, Ting-Yi Renn, Meng-Shan Cheng, Chi-Te Wang, Igor Klimenkov, Nikolay P. Sudakov, Wen-Chieh Liao, Yea-Jyh Chen, Hung-Ming Chang
Summary: Olfactory stimulation can improve swallowing function in aged rats by activating central neuronal networks and downstream muscular activities involved in swallowing control.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Engineering, Environmental
Ting-Yi Renn, Chih-Ping Yang, Un-In Wu, Li-You Chen, Fu -Der Mai, Maria A. Tikhonova, Tamara G. Amstislavskaya, Wen-Chieh Liao, Che -Tong Lin, Yu-Chuan Liu, Hung-Ming Chang
Summary: Melatonin dissolved in plasmon-activated water (PAW) shows stronger anti-viral and anti-oxidative activities compared to traditional organic solvent methods. In vivo studies demonstrate that rats treated with melatonin prepared in PAW exhibit improved oxidative stress levels, hepatic function, and antioxidant enzyme activities. PAW offers potential for clinical use of melatonin as a natural, economical, and efficient therapeutic strategy against virus infection and oxidative damage.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell Biology
Yin-Hung Chu, Wen-Chieh Liao, Ying-Jui Ho, Chih-Hsien Huang, To-Jung Tseng, Chiung-Hui Liu
Summary: This study explores the role of chondroitin sulfate (CS) in glioma progression, focusing on the effects of the major CS synthase CHSY1 and the interaction with CD44 and integrin beta 1. It suggests a potential regulatory loop between CS, CD44, and integrin beta 1 in glioma cells, highlighting the importance of CS in CD44 stability. Targeting CS with specific binding peptides shows promise as a novel therapeutic strategy for glioma.
Article
Immunology
Chiung-Hui Liu, Bo-Shiou Lin, Mei-Yao Wu, Ying-Chyi Song, Tao-Wei Ke, Yu-Lun Chou, Chuan-Teng Liu, Chia-Hsin Lin, Vedran Radojcic, Charles Drake, Hung-Rong Yen
Summary: The IL-4/AKT/Eomes/Trat1 axis promotes the transformation of Tc17 cells into therapeutic cytotoxic effectors. IL-4 priming can be used as a cell therapy engineering strategy to enhance anti-tumor responses.
Review
Immunology
Shuo-Yan Gau, Yu-Ping Hsiao, Wen-Chieh Liao, Kevin Sheng-Kai Ma, Meng-Che Wu
Summary: This study aimed to evaluate the association between hidradenitis suppurativa (HS) and liver diseases and provide integrated evidence. Results suggest that patients with HS are associated with all liver diseases, non-alcoholic fatty liver disease, and hepatitis B, but not hepatitis C. HS patients have a significantly increased risk of liver diseases, especially non-alcoholic fatty liver disease and hepatitis B.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Education, Scientific Disciplines
Mao-Yi Yang, Hsien-Chun Tseng, Chiung-Hui Liu, Shao-Yu Tsai, Jyun-Hsiung Chen, Yin-Hung Chu, Shao-Ti Li, Jian- Lee, Wen-Chieh Liao
Summary: This study aimed to create 3D-printed skull bone models (3D-PSBs) to assist medical students in understanding the spatial structure of the skull. The application of 3D-PSBs was evaluated through a questionnaire and tests, which showed that students' knowledge was improved using these models. Most students agreed that the use of 3D-PSBs with quick response codes provided immediate feedback and clarified the hidden structures within the skull.
ANATOMICAL SCIENCES EDUCATION
(2023)
Article
Engineering, Biomedical
Chiung-Hui Liu, Yin-Hung Chu, Yin Hsiu Chen, Yu Hsin Chiang, Yu Hsuan Chen, Chung Yao Ku, Min-Yen Hsu, Yi-Ju Lee, Mao-Yi Yang, Wen-Chieh Liao
Summary: Peripheral nerve regeneration (PNR) requires the reconstruction of the extracellular matrix (ECM) and the stimulation of growth factors. In this study, we evaluated the effects of combining decellularised small intestine submucosa (SIS) with glial cell-derived growth factor (GDNF) treatment on PNR in a rat model. We found that the combined treatment enhanced neuromuscular function recovery and axonal outgrowth, suggesting a potential therapeutic approach for PNR.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chiung-Hui Liu, Ying-Jui Ho, Che-Yu Wang, Chao-Chun Hsu, Yin-Hung Chu, Min-Yen Hsu, Shiu-Jau Chen, Wen-Chuan Hsiao, Wen-Chieh Liao
Summary: Through studying the regenerative process of peripheral nerves in rats, it was discovered that silencing chondroitin sulfate synthase 1 (Chsy1) can decrease the accumulation of versican and hinder the treatment of nerve injuries. Treating with Chsy1-siRNA was found to be an effective strategy to promote injured peripheral nerve regeneration.
Article
Clinical Neurology
Chia-Hua Chen, Kuo-Chen Wei, Wei-Chao Liao, You-Yu Lin, Hsiu-Chi Chen, Li-Ying Feng, Chiung-Hui Liu, Chiung-Yin Huang, Ko-Ting Chen, Chi-Sheng Wu, Yu-Sun Chang, Jau-Song Yu, Ian Yi-Feng Chang
Summary: The deletion of APOBEC3 gene is associated with increased risk and better survival in male astrocytic glioma patients in Taiwan.
JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying-Chyi Song, To-Jung Tseng, Chiung-Hui Liu
Summary: The upregulation of CHPF in breast cancer contributes to malignant behavior of cancer cells, promoting tumor growth and metastasis. Co-localization of tumor cell-derived G-CSF with CS on the cell surface was found. Breast cancer patients with high expression of both SDC4 and CHPF had worse overall survival, indicating synergistic effects of these two genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Chiung-Hui Liu, Yu-Chen Kuo, Che-Yu Wang, Chao-Chun Hsu, Ying-Jui Ho, Yun-Chi Chiang, Fu-Der Mai, Wei-Jhih Lin, Wen-Chieh Liao
Summary: The study suggests that syndecans may play a role in stabilizing Nav1.6 and modulating the distribution of sodium at nodal regions, leading to better functional repair of peripheral nerve injury. The re-clustering of sodium and Nav1.6 at nodal regions of regenerating nerves correlated with the recovery of muscle power after end-to-side neurorrhaphy.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)