The role of the glypican and syndecan families of heparan sulfate proteoglycans in cardiovascular function and disease

HDAC3 Downregulation Improves Cerebral Ischemic Injury via Regulation of the SDC1-Dependent JAK1/STAT3 Signaling Pathway Through miR-19a Upregulation

(2021) Hua Fang et al.   MOLECULAR NEUROBIOLOGY

Circulating Levels of the Heparan Sulfate Proteoglycan Syndecan-4 Positively Associate with Blood Pressure in Healthy Premenopausal Women

(2021) Maria De Luca et al.   Biomolecules

Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in shear-induced endothelial nitric oxide production

(2021) Anne Marie W. Bartosch et al.   Scientific Reports

Glypican 1 and syndecan 1 differently regulate noradrenergic hypertension development: Focus on IP3R and calcium

(2021) Simone R. Potje et al.   PHARMACOLOGICAL RESEARCH

Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival

(2021) Yuichiro Kitagawa et al.   PLoS One

The Glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease

(2020) Marwa Mahmoud et al.   CARDIOVASCULAR RESEARCH

Can Glypican-6 Level Predict Ejection Fraction Decline After Myocardial Infarction?

(2020) Fatih Ozturk et al.   ANGIOLOGY

Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension

(2020) Mark Lipphardt et al.   Journal of Clinical Medicine

High Blood Pressure and Cardiovascular Disease

(2019) Flávio D. Fuchs et al.   HYPERTENSION

Role of glypican-1 in endothelial NOS activation under various steady shear stress magnitudes

(2016) Ye Zeng et al.   EXPERIMENTAL CELL RESEARCH

Syndecan-4 Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

(2016) Jun Xie et al.   MOLECULAR MEDICINE

Epidemiology and aetiology of heart failure

(2016) Boback Ziaeian et al.   Nature Reviews Cardiology

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling

(2016) Arne O. Melleby et al.   PLoS One

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling

(2015) I. Strate et al.   DEVELOPMENT

Syndecan-4 Is a Major Syndecan in Primary Human Endothelial Cells In Vitro, Modulated by Inflammatory Stimuli and Involved in Wound Healing

(2015) Tram Thu Vuong et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice

(2015) Mari E. Strand et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibrosis Marker Syndecan-1 and Outcome in Patients With Heart Failure With Reduced and Preserved Ejection Fraction

(2014) Jasper Tromp et al.   Circulation-Heart Failure

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

(2014) Eno E. Ebong et al.   Integrative Biology

Loss of Syndecan-1 Induces a Pro-inflammatory Phenotype in Endothelial Cells with a Dysregulated Response to Atheroprotective Flow

(2014) Peter L. Voyvodic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 Regulates Vascular Smooth Muscle Cell Phenotype

(2014) Somali Chaterji et al.   PLoS One

Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart

(2013) Mari E. Strand et al.   FEBS Journal

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

(2012) Andrew Koo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Syndecan 4 regulation of PDK1-dependent Akt activation

(2012) Rong Ju et al.   CELLULAR SIGNALLING

Sdc1 Overexpression Inhibits the p38 MAPK Pathway and Lessens Fibrotic Ventricular Remodeling in MI Rats

(2012) Juan Lei et al.   INFLAMMATION

Reciprocal Regulation of Syndecan-2 and Notch Signaling in Vascular Smooth Muscle Cells

(2012) Ning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-4 Deficiency Limits Neointimal Formation After Vascular Injury by Regulating Vascular Smooth Muscle Cell Proliferation and Vascular Progenitor Cell Mobilization

(2011) Masahiro Ikesue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling

(2011) Frank Echtermeyer et al.   CARDIOVASCULAR RESEARCH

Serum syndecan-4 is a novel biomarker for patients with chronic heart failure

(2011) Rieko Takahashi et al.   Journal of Cardiology

Syndecan-1 promotes the angiogenic phenotype of multiple myeloma endothelial cells

(2011) S Lamorte et al.   LEUKEMIA

Increased level of soluble syndecan-1 in serum correlates with myocardial expression in a rat model of myocardial infarction

(2011) Juan Lei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway

(2011) Alexandra V. Finsen et al.   PLoS One

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Adhesion signalling complexes

(2010) Adam Byron et al.   CURRENT BIOLOGY

Syndecan-1 Amplifies Angiotensin II–Induced Cardiac Fibrosis

(2010) Mark W.M. Schellings et al.   HYPERTENSION

Epidemiology and risk profile of heart failure

(2010) Anh L. Bui et al.   Nature Reviews Cardiology

Syndecan-1

(2009) Nozomi Fukai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development

(2009) Ann Ng et al.   DEVELOPMENTAL BIOLOGY

Syndecan-4 Regulates Subcellular Localization of mTOR Complex2 and Akt Activation in a PKCα-Dependent Manner in Endothelial Cells

(2008) Chohreh Partovian et al.   MOLECULAR CELL