Review
Oncology
Zoi Karagiorgou, Panagiotis N. Fountas, Dimitra Manou, Erik Knutsen, Achilleas D. Theocharis
Summary: Proteoglycans play important roles in various processes of cancer cells, such as migration, invasion, and drug resistance. They influence cell plasticity, stemness, and alter cellular shape and functions through different mechanisms.
Review
Biochemistry & Molecular Biology
Marsioleda Kemberi, Yousuf Salmasi, Salvatore Santamaria
Summary: Thoracic aortic aneurysm and dissection (TAAD) are complex diseases that are difficult to diagnose early. The role of ADAMTSs in thoracic aortic disease and their potential use as biomarkers for diagnosis and disease progression are discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yingying He, Tao Liu, Shuang Dai, Zihan Xu, Li Wang, Feng Luo
Summary: Despite major breakthroughs in cancer immunotherapy, only a small percentage of patients benefit significantly. Chronic inflammation in the tumor microenvironment plays a key role in tumor immunosuppression, with tumor-associated ECM identified as a major obstacle to successful cancer immunotherapy cases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Fengying Tang, Jourdan E. Brune, Mary Y. Chang, Stephen R. Reeves, William A. Altemeier, Charles W. Frevert
Summary: The extracellular matrix plays a critical role in cellular processes in the lungs, with the proteoglycan versican being a key regulator in lung diseases. However, the mechanisms of how versican interacts with its binding partners and forms contextual extracellular matrices are still not fully understood.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Oncology
Priyanka Hirani, Valentine Gauthier, Carys E. E. Allen, Thomas N. N. Wight, Oliver M. T. Pearce
Summary: Studies have shown a connection between the composition of the tissue extracellular matrix and the progression and severity of immunity and inflammatory diseases. The large proteoglycan versican plays a significant role in inflammatory diseases and cancer, but it is unclear whether its expression is directly involved in tumorigenesis. This review focuses on the role of versican in the immune response related to tumor progression, aiming to determine if further research is warranted for versican as a cancer immunotherapy target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Veterinary Sciences
S. H. Figueredo, R. S. Carmo Neto, E. Ferreira, G. D. Cassali, A. Estrela-Lima, K. A. Damasceno
Summary: The proteoglycan versican plays a complex role in cancer, with higher expression levels observed in malignant mixed tumors compared to simple carcinomas. This may be due to the presence of myoepithelial proliferation in the tumor, contributing to the stromal composition and promoting an increase in the expression of versican. Higher levels of versican expression in the stroma adjacent to invasive areas were associated with invasiveness in both simple carcinomas and malignant mixed tumors.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Oncology
Xiaowu Bai, Chi Chun Wong, Yasi Pan, Huarong Chen, Weixin Liu, Jianning Zhai, Wei Kang, Yu Shi, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Philip Chiu, Jun Yu, Enders Kwok-wai Ng
Summary: YTHDF1 is overexpressed in gastric cancer and promotes cancer growth by inducing cell proliferation and suppressing dendritic cell-mediated anti-tumor immune response. YTHDF1 is a promising therapeutic target for gastric cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Zining Wang, Feifei Xu, Jie Hu, Hongxia Zhang, Lei Cui, Wenhua Lu, Wenzhuo He, Xiaojuan Wang, Mengyun Li, Huanling Zhang, Wenjing Xiong, Chunyuan Xie, Yongxiang Liu, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaofeng Frank Qin, Xiaojun Xia
Summary: Clotrimazole was identified as a drug that could enhance DC-mediated antigen presentation and T cell response, by acting on hexokinase 2 to regulate metabolic production and enhancing the lysosome pathway and Chop expression in DCs. In vivo administration of clotrimazole induced immune infiltration and inhibited tumor growth, synergizing with anti-PD1 antibody therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Shamima Islam, Nushrat Jahan, Arbee Shahida, Sivasundaram Karnan, Hideto Watanabe
Summary: The study found that versikine is a direct regulator that inhibits the repair of inflamed tissue, which is of great biological significance.
Article
Cell Biology
Meredith Whitehead, Syabira Yusoff, Sadia Ahmad, Lukas Schmidt, Manuel Mayr, Jillian Madine, David Middleton, Catherine M. Shanahan
Summary: Vascular amyloidosis, caused by the aggregation of peptide monomers into insoluble amyloid, is a common age-related pathology. This study found that extracellular vesicles (EVs) and HSPG2 in the extracellular matrix (ECM) play key roles in medin accumulation, contributing to the development of age-associated aortic medial amyloid (AMA).
Article
Cell Biology
Athanasios Papadas, Gauri Deb, Alexander Cicala, Adam Officer, Chelsea Hope, Adam Pagenkopf, Evan Flietner, Zachary T. Morrow, Philip Emmerich, Joshua Wiesner, Garrett Arauz, Varun Bansal, Karla Esbona, Christian M. Capitini, Kristina A. Matkowskyj, Dustin A. Deming, Katerina Politi, Scott I. Abrams, Olivier Harismendy, Fotis Asimakopoulos
Summary: The stroma near the tumor edge plays a crucial role in regulating the abundance and activity of cDC1, which in turn affects the T cell inflammatory response in the tumor microenvironment.
Article
Medicine, General & Internal
Zhenlin Wang, Zunyun Wang, Xianyu Hu, Qijun Han, Ke Chen, Gang Pang
Summary: This study established an extracellular matrix prognostic model for gastric cancer patients through comparing activated signaling pathways and LASSO regression analysis, which can help evaluate patients' risk of death and response to immunotherapy.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Chemistry, Physical
Saber Shakibi, Patrick R. R. Onck, Erik van der Giessen
Summary: Glycosaminoglycans (GAGs) are polysaccharides that play crucial roles in biological processes. They are important structural components of cartilage and the extracellular matrix of the brain. Coarse-grained modeling is essential due to the large size of GAGs.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Biochemistry & Molecular Biology
Biswajoy Ghosh, Subhashree Chatterjee, Ramgopal Dhakar, Saylee Muley, Pabitra Mitra, Jyotirmoy Chatterjee
Summary: The habit of chewing arecanut can lead to fibrosis in oral tissues, potentially causing cancer. Fibrosis is a progressive condition with limited clinical success, influenced by organ-specific variations and genetic predispositions. Research on the early and late phases of arecanut-induced fibrosis in skin revealed changes in extracellular matrix molecules, such as proteins and glycans, impacting the severity of the matrix state.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Astri J. Meen, Atanaska I. Doncheva, Yvonne Boettcher, Simon N. Dankel, Anne Hoffmann, Matthias Blueher, Johan Ferno, Gunnar Mellgren, Adhideb Ghosh, Wenfei Sun, Hua Dong, Falko Noe, Christian Wolfrum, Gunnar Pejler, Knut Tomas Dalen, Svein O. Kolset
Summary: This study investigated the impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue. Transcriptomic data from human bariatric surgery cohorts and gene analyses in mice revealed altered gene expression in both visceral and subcutaneous adipose tissue depots. The gene expression changes in visceral adipose tissue were more pronounced after surgery, suggesting ongoing adipose tissue repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)