Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor

DDEL-07. A Phase I study examining the feasibility of intermittent convection-enhanced delivery (CED) of MTX110 for the treatment of children with newly diagnosed diffuse midline gliomas (DMGs)

(2022) Stergios Zacharoulis et al.   NEURO-ONCOLOGY

A Therapeutic Sheep in Metastatic Wolf’s Clothing: Trojan Horse Approach for Cancer Brain Metastases Treatment

(2022) Hai-jun Liu et al.   Nano-Micro Letters

Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery

(2021) Lishuai Feng et al.   ACS Nano

Opening doors with ultrasound and microbubbles: beating biological barriers to promote drug delivery

(2021) J. Deprez et al.   ADVANCED DRUG DELIVERY REVIEWS

Strategies for delivering therapeutics across the blood–brain barrier

(2021) Georg C. Terstappen et al.   NATURE REVIEWS DRUG DISCOVERY

Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy

(2021) Xue‐Liang Liu et al.   Advanced Science

Biomimetic Nanomedicine Coupled with Neoadjuvant Chemotherapy to Suppress Breast Cancer Metastasis via Tumor Microenvironment Remodeling

(2021) Hai‐jun Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Biomimetic and cell-based nanocarriers – New strategies for brain tumor targeting

(2021) D. Mendanha et al.   JOURNAL OF CONTROLLED RELEASE

Brain-targeted, drug-loaded solid lipid nanoparticles against glioblastoma cells in culture

(2021) Güliz Ak et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Biomimetic, Hypoxia‐Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co‐Targeting of Therapy‐Induced Bone Marrow Niches

(2020) Xiao Dong et al.   ADVANCED FUNCTIONAL MATERIALS

Camouflaging Nanoparticles with Brain Metastatic Tumor Cell Membranes: A New Strategy to Traverse Blood–Brain Barrier for Imaging and Therapy of Brain Tumors

(2020) Caixia Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Autocatalytic Delivery of Brain Tumor–Targeting, Size‐Shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases

(2020) Shenqi Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors

(2020) Hao Wu et al.   ADVANCED MATERIALS

PEGylated nanocarriers: A promising tool for targeted delivery to the brain

(2020) K.R. Gajbhiye et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells

(2020) Sharon M. Sagnella et al.   CANCER CELL

Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma

(2020) Bhavesh K. Ahir et al.   MOLECULAR NEUROBIOLOGY

L-Type amino acid transporter 1 as a target for drug delivery

(2020) Elena Puris et al.   PHARMACEUTICAL RESEARCH

Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection

(2020) Colleen T. Curley et al.   Science Advances

Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids

(2020) Shuhua Li et al.   Nature Biomedical Engineering

Targeting Microglia for Therapy of Parkinson’s Disease by Using Biomimetic Ultrasmall Nanoparticles

(2020) Hanghang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

(2019) Todd Mainprize et al.   Scientific Reports

Brain metastases

(2019) Achal Singh Achrol et al.   Nature Reviews Disease Primers

Glutathione (GSH) Peptide Conjugated Magnetic Nanoparticles As Blood–Brain Barrier Shuttle for MRI-Monitored Brain Delivery of Paclitaxel

(2019) Hamed Nosrati et al.   ACS Biomaterials-Science & Engineering

Treatment of multiple brain metastases using gadolinium nanoparticles and radiotherapy: NANO-RAD, a phase I study protocol

(2019) Camille Verry et al.   BMJ Open

Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

(2019) Ahmed Idbaih et al.   CLINICAL CANCER RESEARCH

Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

(2019) Lei Han et al.   ADVANCED MATERIALS

A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

(2019) Di Wu et al.   ADVANCED MATERIALS

Nanoparticles Surmounting Blood–Brain Tumor Barrier Through Both Transcellular and Paracellular Pathways to Target Brain Metastases

(2019) Tongtong Miao et al.   ADVANCED FUNCTIONAL MATERIALS

Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration

(2019) Duo Xu et al.   ADVANCED MATERIALS

Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells

(2019) Junning Ma et al.   Small

In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy

(2019) Zhenbao Li et al.   Asian Journal of Pharmaceutical Sciences

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice

(2019) Jing Wen et al.   Nature Biomedical Engineering

Cancer Cell Membrane-Coated Nanoparticles for Cancer Management

(2019) Jenna C. Harris et al.   Cancers

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

(2019) Jinbing Xie et al.   BIOMATERIALS

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

Highly efficacious and specific anti-glioma chemotherapy by tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides

(2018) Yaqin Zhu et al.   JOURNAL OF CONTROLLED RELEASE

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial

(2018) Roberto Giugliani et al.   Orphanet Journal of Rare Diseases

Cognitive impairment and morphological changes after radiation therapy in brain tumors: A review

(2018) Julian Jacob et al.   RADIOTHERAPY AND ONCOLOGY

Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment

(2018) Meiying Wu et al.   Advanced Science

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends

(2018) Hira Choudhury et al.   Drug Delivery and Translational Research

Gold Nanoparticles for Brain Tumor Imaging: A Systematic Review

(2018) Antonio Meola et al.   Frontiers in Neurology

Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

(2018) Elizabeth M. Rhea et al.   JOURNAL OF PHYSIOLOGY-LONDON

OUP accepted manuscript

(2018)   NEURO-ONCOLOGY

D-T7 Peptide-Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma

(2018) Meinan Yu et al.   ACS Applied Materials & Interfaces

Acid-Induced Activated Cell-Penetrating Peptide-Modified Cholesterol-Conjugated Polyoxyethylene Sorbitol Oleate Mixed Micelles for pH-Triggered Drug Release and Efficient Brain Tumor Targeting Based on a Charge Reversal Mechanism

(2018) Yu Tian et al.   ACS Applied Materials & Interfaces

Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model

(2018) Sushant Lakkadwala et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Mechanisms of glutathione-conjugate efflux from the brain into blood: Involvement of multiple transporters in the course

(2018) Toshimitsu Okamura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles

(2017) Ana Miranda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery

(2017) Zhilan Chai et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption

(2017) Juyoung Park et al.   JOURNAL OF CONTROLLED RELEASE

Noninvasive nanoparticle strategies for brain tumor targeting

(2017) Chunmeng Sun et al.   Nanomedicine-Nanotechnology Biology and Medicine

Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials

(2017) Yung-Hao Tsou et al.   Small

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

(2017) Y. Anraku et al.   Nature Communications

Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

(2017) Keitaro Hayashi et al.   World Journal of Gastrointestinal Oncology

472PPHASE 1/2A STUDY OF GLUTATHIONE PEGYLATED LIPOSOMAL DOXORUBICIN (2B3-101) IN PATIENTS WITH BRAIN METASTASES (BM) FROM SOLID TUMORS OR RECURRENT HIGH GRADE GLIOMAS (HGG)

(2017) D. Brandsma et al.   ANNALS OF ONCOLOGY

Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy

(2016) Yanna Cui et al.   ACS Applied Materials & Interfaces

Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging

(2016) Liang Han et al.   ACS Nano

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Large amino acid transporter 1 mediated glutamate modified docetaxel-loaded liposomes for glioma targeting

(2016) Lin Li et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Brain tumor-targeted therapy by systemic delivery of siRNA with Transferrin receptor-mediated core-shell nanoparticles

(2016) Lin Wei et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies

(2016) Antonella Mangraviti et al.   JOURNAL OF CONTROLLED RELEASE

Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins

(2016) Sheng Liang et al.   Nano Research

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Transferrin conjugated nontoxic carbon dots for doxorubicin delivery to target pediatric brain tumor cells

(2016) Shanghao Li et al.   Nanoscale

The role of the low-density lipoprotein receptor–related protein 1 (LRP-1) in regulating blood-brain barrier integrity

(2016) Yahui Zhao et al.   REVIEWS IN THE NEUROSCIENCES

Preparation of iron oxide nanoparticles functionalized with Y-shaped ligands for brain tumor targeting

(2016) Gwangjin Noh et al.   Journal of Materials Chemistry B

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Tumor tropic delivery of doxorubicin-polymer conjugates using mesenchymal stem cells for glioma therapy

(2015) Xiaofeng Zhang et al.   BIOMATERIALS

Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

(2015) Sara Salatin et al.   CELL BIOLOGY INTERNATIONAL

Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood-brain barrier

(2015) KE Parrish et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Transferrin receptor-targeted vitamin E TPGS micelles for brain cancer therapy: preparation, characterization and brain distribution in rats

(2015) Sonali et al.   DRUG DELIVERY

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery

(2015) Seyed Nasrollah Tabatabaei et al.   JOURNAL OF CONTROLLED RELEASE

Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas

(2015) Suraj Dixit et al.   MOLECULAR PHARMACEUTICS

Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors

(2015) Suraj Dixit et al.   Nanoscale

Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma

(2015) Rajneet K. Oberoi et al.   NEURO-ONCOLOGY

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid

(2015) Manuela Porru et al.   Oncotarget

Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation

(2014) Twan Lammers et al.   ADVANCED FUNCTIONAL MATERIALS

The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles

(2014) Yang Deng et al.   BIOMATERIALS

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Role of Monocarboxylate Transporters in Drug Delivery to the Brain

(2014) Nisha Vijay et al.   CURRENT PHARMACEUTICAL DESIGN

Polymersomes conjugated to 83-14 monoclonal antibodies: Invitro targeting of brain capillary endothelial cells

(2014) Le-Ha Dieu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intra-arterial delivery of AAV vectors to the mouse brain after mannitol mediated blood brain barrier disruption

(2014) Conor P. Foley et al.   JOURNAL OF CONTROLLED RELEASE

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview

(2014) Hao-Li Liu et al.   Theranostics

Magnetic Core-Shell Nanocapsules with Dual-Targeting Capabilities and Co-Delivery of Multiple Drugs to Treat Brain Gliomas

(2014) Jen-Hung Fang et al.   Advanced Healthcare Materials

The application of magnetic nanoparticles for the treatment of brain tumors

(2014) Keon Mahmoudi et al.   Frontiers in Chemistry

Brain tumor-targeted drug delivery strategies

(2014) Xiaoli Wei et al.   Acta Pharmaceutica Sinica B

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier

(2014) Julia Georgieva et al.   Pharmaceutics

Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment

(2013) Yanna Cui et al.   BIOMATERIALS

Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment

(2013) Xinyi Jiang et al.   BIOMATERIALS

Acute effects of short-chain alkylglycerols on blood-brain barrier properties of cultured brain endothelial cells

(2013) P Hülper et al.   BRITISH JOURNAL OF PHARMACOLOGY

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

(2013) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

Solid lipid nanoparticles carrying chemotherapeutic drug across the blood–brain barrier through insulin receptor-mediated pathway

(2013) Yung-Chih Kuo et al.   JOURNAL OF DRUG TARGETING

Phenylalanine-coupled solid lipid nanoparticles for brain tumor targeting

(2013) Parul Kharya et al.   JOURNAL OF NANOPARTICLE RESEARCH

Whole Brain Radiation-Induced Vascular Cognitive Impairment: Mechanisms and Implications

(2013) Junie P. Warrington et al.   JOURNAL OF VASCULAR RESEARCH

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Focused Ultrasound-Induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study

(2013) Kuo-Chen Wei et al.   PLoS One

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

(2013) D. T. Wiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

(2013) P. Kolhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoprobes Visualizing Gliomas by Crossing the Blood Brain Tumor Barrier

(2013) Xihui Gao et al.   Small

LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis

(2013) Nicolas Etique et al.   Biomed Research International

Recruitment of monocytes/macrophages in different tumor microenvironments

(2012) Heon-Woo Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Blood-Brain/Tumor Barriers: Challenges and Chances for Malignant Gliomas Targeted Drug Delivery

(2012) Changyou Zhan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme

(2012) Feng-Yi Yang et al.   JOURNAL OF CONTROLLED RELEASE

Magnetic targeting of nanoparticles across the intact blood–brain barrier

(2012) Seong Deok Kong et al.   JOURNAL OF CONTROLLED RELEASE

β-Hydroxybutyric acid grafted solid lipid nanoparticles: A novel strategy to improve drug delivery to brain

(2012) Vinay Kumar Venishetty et al.   Nanomedicine-Nanotechnology Biology and Medicine

Functional roles of transferrin in the brain

(2011) Dominique F. Leitner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

(2011) Kai Xiao et al.   BIOMATERIALS

Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment

(2011) Chien-Yu Ting et al.   BIOMATERIALS

Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1

(2011) Y Bertrand et al.   BRITISH JOURNAL OF CANCER

Finding the anaplastic focus in diffuse gliomas: The value of Gd-DTPA enhanced MRI, FET-PET, and intraoperative, ALA-derived tissue fluorescence

(2011) Christian Ewelt et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Cell-mediated drug delivery

(2011) Elena V Batrakova et al.   Expert Opinion on Drug Delivery

Transport of drugs across the blood–brain barrier by nanoparticles

(2011) Stefanie Wohlfart et al.   JOURNAL OF CONTROLLED RELEASE

Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier

(2011) A. J. Carman et al.   JOURNAL OF NEUROSCIENCE

The biology of brain metastases—translation to new therapies

(2011) April F. Eichler et al.   Nature Reviews Clinical Oncology

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors

(2010) Hai He et al.   BIOMATERIALS

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level

(2010) Jan Chr. Pedersen et al.   CLINICAL GENETICS

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

(2010) Karsten Ulbrich et al.   JOURNAL OF DRUG TARGETING

In vitroandin vivoinvestigation of glucose-mediated brain-targeting liposomes

(2010) Yao Qin et al.   JOURNAL OF DRUG TARGETING

Mechanism of Low-Frequency Ultrasound in Opening Blood–Tumor Barrier by Tight Junction

(2010) Xiuli Shang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma

(2010) John A. Boockvar et al.   JOURNAL OF NEUROSURGERY

Targeted Imaging and Therapy of Brain Cancer Using Theranostic Nanoparticles

(2010) Mahaveer Swaroop Bhojani et al.   MOLECULAR PHARMACEUTICS

Loop 2 of Ophiophagus hannah Toxin b Binds with Neuronal Nicotinic Acetylcholine Receptors and Enhances Intracranial Drug Delivery

(2010) Changyou Zhan et al.   MOLECULAR PHARMACEUTICS

Toward Brain Tumor Gene Therapy Using Multipotent Mesenchymal Stromal Cell Vectors

(2010) Daniel Bexell et al.   MOLECULAR THERAPY

The impact of standing wave effects on transcranial focused ultrasound disruption of the blood–brain barrier in a rat model

(2010) Meaghan A O'Reilly et al.   PHYSICS IN MEDICINE AND BIOLOGY

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-Brain Barrier Disruption with Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment

(2010) Hao-Li Liu et al.   RADIOLOGY

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model

(2009) Chun-Xia Wang et al.   BRAIN RESEARCH

Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors

(2009) Hemant Sarin et al.   Journal of Translational Medicine

Permeability of the blood–brain barrier depends on brain temperature

(2009) E.A. Kiyatkin et al.   NEUROSCIENCE

Effect of Surface Properties on Nanoparticle–Cell Interactions

(2009) Ayush Verma et al.   Small

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

(2008) Karsten Ulbrich et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Stem and progenitor cell-mediated tumor selective gene therapy

(2008) K S Aboody et al.   GENE THERAPY

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells

(2008) Hemant Sarin et al.   Journal of Translational Medicine

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA