Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood-brain barrier

Incidence and characteristics of melanoma brain metastases developing during treatment with vemurafenib

(2014) L. Peuvrel et al.   JOURNAL OF NEURO-ONCOLOGY

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione Pegylated Liposomal Doxorubicin (2B3-101)

(2014) Pieter J. Gaillard et al.   PLoS One

Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening

(2014) Ching-Hsiang Fan et al.   Theranostics

Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview

(2014) Hao-Li Liu et al.   Theranostics

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

(2013) Jörg Kreuter   ADVANCED DRUG DELIVERY REVIEWS

Transport of gabapentin by LAT1 (SLC7A5)

(2013) David Dickens et al.   BIOCHEMICAL PHARMACOLOGY

Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model

(2013) Rachel Grossman et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Why Clinical Modulation of Efflux Transport at the Human Blood–Brain Barrier Is Unlikely: The ITC Evidence-Based Position

(2013) J C Kalvass et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The role of Gliadel wafers in the treatment of high-grade gliomas

(2013) Amade Bregy et al.   Expert Review of Anticancer Therapy

Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma

(2013) Kerstin Trunzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer

(2013) Carey K. Anders et al.   PLoS One

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α

(2012) Timothy P. Heffron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma

(2012) David A. Reardon et al.   JOURNAL OF NEURO-ONCOLOGY

The role of LAT1 in 18F-DOPA uptake in malignant gliomas

(2012) Ryan S. Youland et al.   JOURNAL OF NEURO-ONCOLOGY

Melanoma Brain Metastases and Vemurafenib: Need for Further Investigation

(2012) Nicole M. Rochet et al.   MAYO CLINIC PROCEEDINGS

Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents

(2012) S. Agarwal et al.   MOLECULAR CANCER THERAPEUTICS

Transferrin-Modified c[RGDfK]-Paclitaxel Loaded Hybrid Micelle for Sequential Blood-Brain Barrier Penetration and Glioma Targeting Therapy

(2012) Pengcheng Zhang et al.   MOLECULAR PHARMACEUTICS

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioblastoma: From Molecular Pathology to Targeted Treatment

(2011) Timothy F. Cloughesy et al.   Annual Review of Pathology-Mechanisms of Disease

Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain

(2011) Sagar Agarwal et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

Gene expression profiling of gliomas: merging genomic and histopathological classification for personalised therapy

(2010) M Vitucci et al.   BRITISH JOURNAL OF CANCER

Intratumoral Therapy of Glioblastoma Multiforme Using Genetically Engineered Transferrin for Drug Delivery

(2010) Dennis J. Yoon et al.   CANCER RESEARCH

Phase II Evaluation of Gefitinib in Patients With Newly Diagnosed Grade 4 Astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074

(2010) Joon H. Uhm et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The paradoxical effect of bevacizumab in the therapy of malignant gliomas

(2010) E. M. Thompson et al.   NEUROLOGY

De novo Induction of Genetically Engineered Brain Tumors in Mice Using Plasmid DNA

(2009) S. M. Wiesner et al.   CANCER RESEARCH

Brain Metastasis: Opportunities in Basic and Translational Research

(2009) E. A. Maher et al.   CANCER RESEARCH

High-grade glioma mouse models and their applicability for preclinical testing

(2009) Nienke A. de Vries et al.   CANCER TREATMENT REVIEWS

Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience

(2009) Lilyana Angelov et al.   JOURNAL OF CLINICAL ONCOLOGY

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

(2009) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme

(2009) David M. Peereboom et al.   JOURNAL OF NEURO-ONCOLOGY

Poor drug distribution as a possible explanation for the results of the PRECISE trial

(2009) John H. Sampson et al.   JOURNAL OF NEUROSURGERY

Recent Advances in Blood–Brain Barrier Disruption as a CNS Delivery Strategy

(2008) Marc-André Bellavance et al.   AAPS Journal

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study

(2008) Jaishri O. Blakeley et al.   JOURNAL OF NEURO-ONCOLOGY

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

(2008) Michel Demeule et al.   JOURNAL OF NEUROCHEMISTRY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Central Nervous System Metastases in HER-2-Overexpressing Metastatic Breast Cancer: A Treatment Challenge

(2008) H.-J. Stemmler et al.   ONCOLOGIST

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE