Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors

A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

(2019) Di Wu et al.   ADVANCED MATERIALS

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

(2019) Sarah M. Bronner et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Two-Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2-Positive Breast Cancer

(2018) Chunsheng He et al.   ADVANCED FUNCTIONAL MATERIALS

Acid-Responsive Transferrin Dissociation and GLUT Mediated Exocytosis for Increased Blood-Brain Barrier Transcytosis and Programmed Glioma Targeting Delivery

(2018) Shaobo Ruan et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor-Specific Self-Degradable Nanogels as Potential Carriers for Systemic Delivery of Anticancer Proteins

(2018) Qiuwen Zhu et al.   ADVANCED FUNCTIONAL MATERIALS

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas

(2018) Sharmistha Pal et al.   CANCER RESEARCH

Dual-targeting immunoliposomes using angiopep-2 and CD133 antibody for glioblastoma stem cells

(2018) Jung Seok Kim et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes

(2018) Simon J. Hawkins et al.   Nature Nanotechnology

DIPG-35. A NOVEL HDAC INHIBITOR IN NEW PATIENT-DERIVED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) MODELS

(2018) Matthew Biery et al.   NEURO-ONCOLOGY

Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

(2018) Tuoyi Li et al.   Nature Communications

Current Strategies for Brain Drug Delivery

(2018) Xiaowei Dong   Theranostics

Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective

(2018) Quanguo He et al.   Cells

3-Carboxyphenylboronic acid-modified carboxymethyl chitosan nanoparticles for improved tumor targeting and inhibitory

(2017) Xin Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors

(2017) Michelle De Witt et al.   MOLECULAR MEDICINE

Untangling the role of mutant histone H3 in diffuse intrinsic pontine glioma

(2017) Caretha L Creasy   NATURE MEDICINE

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

(2017) Faizaan Mohammad et al.   NATURE MEDICINE

Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma

(2017) Rintaro HASHIZUME   NEUROLOGIA MEDICO-CHIRURGICA

Targeting TRK family proteins in cancer

(2017) Yekaterina B. Khotskaya et al.   PHARMACOLOGY & THERAPEUTICS

Sorting Tubules Regulate Blood-Brain Barrier Transcytosis

(2017) Roberto Villaseñor et al.   Cell Reports

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells

(2017) Tongcheng Qian et al.   Science Advances

Sialic Acid-Targeted Nanovectors with Phenylboronic Acid-Grafted Polyethylenimine Robustly Enhance siRNA-Based Cancer Therapy

(2016) Manyi Ji et al.   ACS Applied Materials & Interfaces

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

(2016) Mahdi Karimi et al.   CHEMICAL SOCIETY REVIEWS

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

(2016) David S. Hersh et al.   CURRENT PHARMACEUTICAL DESIGN

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles

(2016) Naroa Serna et al.   Nanomedicine-Nanotechnology Biology and Medicine

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters

(2016) Dong Deng et al.   PROTEIN SCIENCE

Phenylboronic Acid-Mediated Tumor Targeting of Chitosan Nanoparticles

(2016) Xin Wang et al.   Theranostics

Extracellular electrical recording of pH-triggered bursts in C6 glioma cell populations

(2016) Paulo R. F. Rocha et al.   Science Advances

Portraying breast cancers with long noncoding RNAs

(2016) O. Van Grembergen et al.   Science Advances

Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties

(2015) Volkan Yesilyurt et al.   ADVANCED MATERIALS

Current strategies for targeted delivery of bio-active drug molecules in the treatment of brain tumor

(2015) Tarun Garg et al.   JOURNAL OF DRUG TARGETING

Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma

(2015) Shaobo Ruan et al.   Nanoscale

Multifunctional Nanostructures for Tumor-Targeted Molecular Imaging and Photodynamic Therapy

(2015) Hao Wu et al.   Advanced Healthcare Materials

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

(2015) Sofie Stalmans et al.   PLoS One

Sialic Acids Sweeten a Tumor's Life

(2014) C. Bull et al.   CANCER RESEARCH

Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation ofIDH

(2014) J. Gregory Cairncross et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

Brain tumor-targeted drug delivery strategies

(2014) Xiaoli Wei et al.   Acta Pharmaceutica Sinica B

Choline transporter-targeting and co-delivery system for glioma therapy

(2013) Jianfeng Li et al.   BIOMATERIALS

The core-inversible micelles for hydrophilic drug delivery

(2013) Wenzhe Huang et al.   CHEMICAL COMMUNICATIONS

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

(2013) Yiguang Wang et al.   NATURE MATERIALS

Overcoming the Blood-Brain Barrier in Chemotherapy Treatment of Pediatric Brain Tumors

(2013) Linfeng Wu et al.   PHARMACEUTICAL RESEARCH

Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values andcis-Diols

(2012) Yuanpei Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A dual-targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas

(2012) Yan Li et al.   BIOMATERIALS

Recent advances in brain tumor-targeted nano-drug delivery systems

(2012) Yu Liu et al.   Expert Opinion on Drug Delivery

Nanoparticles for imaging and treating brain cancer

(2012) Joseph D Meyers et al.   Nanomedicine

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

(2009) Yu-Ling Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis

(2007) Matthias Nahrendorf et al.   CIRCULATION