Molecular mechanisms of epilepsy

Megalencephaly and hemimegalencephaly: Breakthroughs in molecular etiology

(2014) Ghayda M. Mirzaa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

On the nature of seizure dynamics

(2014) Viktor K. Jirsa et al.   BRAIN

Behavioral state-dependent modulation of distinct interneuron subtypes and consequences for circuit function

(2014) Jason C Wester et al.   CURRENT OPINION IN NEUROBIOLOGY

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

Distinct neurological disorders with ATP1A3 mutations

(2014) Erin L Heinzen et al.   LANCET NEUROLOGY

Malformations of cortical development: clinical features and genetic causes

(2014) Renzo Guerrini et al.   LANCET NEUROLOGY

GABRA1 and STXBP1: Novel genetic causes of Dravet syndrome

(2014) G. L. Carvill et al.   NEUROLOGY

Interneurons from Embryonic Development to Cell-Based Therapy

(2014) D. G. Southwell et al.   SCIENCE

Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation

(2014) Candi L. LaSarge et al.   Frontiers in Molecular Neuroscience

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

(2013) Yu Liu et al.   ANNALS OF NEUROLOGY

Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release

(2013) Pascal S. Kaeser et al.   Annual Review of Physiology

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies

(2013) Krishna R. Veeramah et al.   EPILEPSIA

A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials

(2013) Michael Wong   Expert Review of Neurotherapeutics

PI3K-Akt Signaling Activates mTOR-Mediated Epileptogenesis in Organotypic Hippocampal Culture Model of Post-Traumatic Epilepsy

(2013) Y. Berdichevsky et al.   JOURNAL OF NEUROSCIENCE

The Molecular Biology of Genetic-Based Epilepsies

(2013) Hao Deng et al.   MOLECULAR NEUROBIOLOGY

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

GRIN2A mutations cause epilepsy-aphasia spectrum disorders

(2013) Gemma L Carvill et al.   NATURE GENETICS

Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus

(2013) David E. Naylor et al.   NEUROBIOLOGY OF DISEASE

Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid

(2013) Pishan Chang et al.   NEUROBIOLOGY OF DISEASE

Extending the KCNQ2 encephalopathy spectrum: Clinical and neuroimaging findings in 17 patients

(2013) S. Weckhuysen et al.   NEUROLOGY

Molecular mechanisms driving homeostatic plasticity of neurotransmitter release

(2013) Vesna Lazarevic et al.   Frontiers in Cellular Neuroscience

A genetically-encoded chloride and pH sensor for dissociating ion dynamics in the nervous system

(2013) Joseph Raimondo   Frontiers in Cellular Neuroscience

mRNA surveillance and endoplasmic reticulum quality control processes alter biogenesis of mutant GABAAreceptor subunits associated with genetic epilepsies

(2012) Robert L. Macdonald et al.   EPILEPSIA

Regulators of synaptic transmission: Roles in the pathogenesis and treatment of epilepsy

(2012) Pablo M. Casillas-Espinosa et al.   EPILEPSIA

Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS

(2012) Sanjeev Rajakulendran et al.   Nature Reviews Neurology

Pyramidal cells accumulate chloride at seizure onset

(2012) Kyle P. Lillis et al.   NEUROBIOLOGY OF DISEASE

Nocturnal Frontal Lobe Epilepsy and the Acetylcholine Receptor

(2012) Luigi Ferini-Strambi et al.   NEUROLOGIST

The Impact of MeCP2 Loss- or Gain-of-Function on Synaptic Plasticity

(2012) Elisa S Na et al.   NEUROPSYCHOPHARMACOLOGY

Chemical toxins that cause seizures

(2012) David A. Jett   NEUROTOXICOLOGY

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

Neuronal homeostasis: time for a change?

(2011) Timothy O’Leary et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentation

(2011) V. Volman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short- and long-term depression at glutamatergic synapses on hippocampal interneurons by group I mGluR activation

(2010) Caroline Le Duigou et al.   NEUROPHARMACOLOGY

Endogenous Nitric Oxide Is a Key Promoting Factor for Initiation of Seizure-Like Events in Hippocampal and Entorhinal Cortex Slices

(2009) R. Kovacs et al.   JOURNAL OF NEUROSCIENCE

Surviving Hilar Somatostatin Interneurons Enlarge, Sprout Axons, and Form New Synapses with Granule Cells in a Mouse Model of Temporal Lobe Epilepsy

(2009) W. Zhang et al.   JOURNAL OF NEUROSCIENCE

Disruption of Normal Cytoskeletal Dynamics May Play a Key Role in the Pathogenesis of Epilepsy

(2009) John Gardiner et al.   NEUROSCIENTIST

Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus

(2008) H. P. Goodkin et al.   JOURNAL OF NEUROSCIENCE

Kainate receptors: Pharmacology, function and therapeutic potential

(2008) David E. Jane et al.   NEUROPHARMACOLOGY

Catamenial epilepsy: Definition, prevalence pathophysiology and treatment

(2008) Andrew G. Herzog   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology