Converging roles of ion channels, calcium, metabolic stress, and activity pattern ofSubstantia nigradopaminergic neurons in health and Parkinson's disease

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens

(2016) Enoch Ng et al.   BEHAVIOURAL BRAIN RESEARCH

A new dopaminergic nigro-olfactory projection

(2015) Günter U. Höglinger et al.   ACTA NEUROPATHOLOGICA

Parkinson's disease as a result of aging

(2015) Manuel Rodriguez et al.   AGING CELL

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

(2015) Ziv Gan-Or et al.   Autophagy

Kv4 channel blockade reduces motor and neuropsychiatric symptoms in rodent models of Parkinson’s disease

(2015) Sabrine Aidi-knani et al.   BEHAVIOURAL PHARMACOLOGY

Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides

(2015) H. de Wet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SOCE in neurons: Signaling or just refilling?

(2015) Lukasz Majewski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

(2015) Kevin T. Beier et al.   CELL

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores

(2015) Giorgio Fois et al.   CELL CALCIUM

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

KATP channel block prevents proteasome inhibitor-induced apoptosis in differentiated PC12 cells

(2015) Yoon Jeong Nam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

(2015) Edgar R. Kramer et al.   FEBS LETTERS

Tonic Firing Rate Controls Dendritic Ca2+ Signaling and Synaptic Gain in Substantia Nigra Dopamine Neurons

(2015) T. A. Hage et al.   JOURNAL OF NEUROSCIENCE

Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons

(2015) T. Kimm et al.   JOURNAL OF NEUROSCIENCE

Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila

(2015) Trayambak Pathak et al.   JOURNAL OF NEUROSCIENCE

Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains

(2015) Katherine R. Brimblecombe et al.   JOURNAL OF PHYSIOLOGY-LONDON

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

A concerted action of L- and T-type Ca2+ channels regulates locus coeruleus pacemaking

(2015) Lina A. Matschke et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Glucocerebrosidase and Parkinson disease: Recent advances

(2015) Anthony H.V. Schapira   MOLECULAR AND CELLULAR NEUROSCIENCE

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

(2015) Ariadna Laguna et al.   NATURE NEUROSCIENCE

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

(2015) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells

(2015) Giulia Ambrosi et al.   NEUROBIOLOGY OF DISEASE

From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases

(2015) Francesco Roselli et al.   NEURON

Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective

(2015) Marco Pignatelli et al.   NEURON

Dopamine midbrain neurons in health and Parkinson’s disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels

(2015) E. Dragicevic et al.   NEUROSCIENCE

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

(2015) Howard Prentice et al.   Oxidative Medicine and Cellular Longevity

Somatodendritic dopamine release: recent mechanistic insights

(2015) Margaret E. Rice et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Release of chemical transmitters from cell bodies and dendrites of nerve cells

(2015) Francisco F. De-Miguel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Parkinson’s disease: From human genetics to clinical trials

(2015) Marcel P. van der Brug et al.   Science Translational Medicine

Deciphering voltage-gated Na+ and Ca2+ channels by studying prokaryotic ancestors

(2015) William A. Catterall et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Impaired intracellular trafficking defines early Parkinson's disease

(2015) Benjamin H.M. Hunn et al.   TRENDS IN NEUROSCIENCES

Cell-type-specific tuning of Cav1.3 Ca2+-channels by a C-terminal automodulatory domain

(2015) Anja Scharinger et al.   Frontiers in Cellular Neuroscience

Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice

(2015) Christina Poetschke et al.   Scientific Reports

Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study

(2015) Ruth Brauer et al.   PLOS MEDICINE

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein

(2015) Carine Ciron et al.   Acta Neuropathologica Communications

Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents

(2015) Carolina Lahmann et al.   PLoS One

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Causes and Consequences of Degeneration of the Dorsal Motor Nucleus of the Vagus Nerve in Parkinson's Disease

(2014) James G. Greene   ANTIOXIDANTS & REDOX SIGNALING

KCa and Ca2+ channels: The complex thought

(2014) Maxime Guéguinou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

C-Terminal Modulatory Domain Controls Coupling of Voltage-Sensing to Pore Opening in Cav1.3 L-type Ca2+ Channels

(2014) Andreas Lieb et al.   BIOPHYSICAL JOURNAL

Magic shotgun for Parkinson’s disease?

(2014) Roger L. Albin et al.   BRAIN

Calcium currents regulate dopamine autoreceptors

(2014) Anders Borgkvist et al.   BRAIN

Glucocerebrosidase is shaking up the synucleinopathies

(2014) Marina Siebert et al.   BRAIN

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons

(2014) Elena Dragicevic et al.   BRAIN

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

(2014) Alisdair McNeill et al.   BRAIN

Dopamine receptors - IUPHAR Review 13

(2014) Jean-Martin Beaulieu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcium signaling in Parkinson’s disease

(2014) Tito Calì et al.   CELL AND TISSUE RESEARCH

Neuronal calcium signaling: function and dysfunction

(2014) Marisa Brini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ERdj3 Is an Endoplasmic Reticulum Degradation Factor for Mutant Glucocerebrosidase Variants Linked to Gaucher’s Disease

(2014) Yun Lei Tan et al.   CHEMISTRY & BIOLOGY

Does Parkinson’s Disease and Type-2 Diabetes Mellitus Present Common Pathophysiological Mechanisms and Treatments?

(2014) Marcelo Lima et al.   CNS & Neurological Disorders-Drug Targets

Reliance of ER–mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ binding proteins: Miros, MICUs, LETM1 and solute carriers

(2014) György Hajnóczky et al.   CURRENT OPINION IN CELL BIOLOGY

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice

(2014) Meike Diepenbroek et al.   HUMAN MOLECULAR GENETICS

Regulation of Gene Transcription by Voltage-gated L-type Calcium Channel, Cav1.3

(2014) Ling Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Neuroprotective and Anti-Inflammatory Effects of L-Type Voltage Dependent Calcium Channel and Ryanodine Receptor Antagonists in the Substantia Nigra and Locus Coeruleus

(2014) Sarah C. Hopp et al.   Journal of Neuroimmune Pharmacology

Aging Decreases L-Type Calcium Channel Currents and Pacemaker Firing Fidelity in Substantia Nigra Dopamine Neurons

(2014) S. Y. Branch et al.   JOURNAL OF NEUROSCIENCE

Mutant α-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels

(2014) Mahalakshmi Subramaniam et al.   JOURNAL OF NEUROSCIENCE

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

(2014) D. Games et al.   JOURNAL OF NEUROSCIENCE

Inhibition of A-Type Potassium Current by the Peptide Toxin SNX-482

(2014) T. Kimm et al.   JOURNAL OF NEUROSCIENCE

Distinct neurological disorders with ATP1A3 mutations

(2014) Erin L Heinzen et al.   LANCET NEUROLOGY

Firing Pattern Modulation Through SK Channel Current Increase Underlies Neuronal Survival in an Organotypic Slice Model of Parkinson’s Disease

(2014) Yuan Wang et al.   MOLECULAR NEUROBIOLOGY

7 tesla magnetic resonance imaging: A closer look at substantia nigra anatomy in Parkinson's disease

(2014) Stéphane Lehéricy et al.   MOVEMENT DISORDERS

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease

(2014) Falk Schlaudraff et al.   NEUROBIOLOGY OF AGING

System-based approaches to decode the molecular links in Parkinson's disease and diabetes

(2014) Jose A. Santiago et al.   NEUROBIOLOGY OF DISEASE

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

Generating bursts (and pauses) in the dopamine midbrain neurons

(2014) C.A. Paladini et al.   NEUROSCIENCE

The role of D2-autoreceptors in regulating dopamine neuron activity and transmission

(2014) C.P. Ford   NEUROSCIENCE

Metabolic Syndrome: An Important Risk Factor for Parkinson’s Disease

(2014) Pei Zhang et al.   Oxidative Medicine and Cellular Longevity

Glucocerebrosidase mutations in primary parkinsonism

(2014) Rosanna Asselta et al.   PARKINSONISM & RELATED DISORDERS

T-type channels buddy up

(2014) Ray W. Turner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function

(2014) Franz Hofmann et al.   PHYSIOLOGICAL REVIEWS

Diabetes and Risk of Parkinson's Disease: An Updated Meta-Analysis of Case-Control Studies

(2014) Lin Lu et al.   PLoS One

Reciprocal Regulation of Reactive Oxygen Species and Phospho-CREB Regulates Voltage Gated Calcium Channel Expression during Mycobacterium tuberculosis Infection

(2014) Arti Selvakumar et al.   PLoS One

Modulatory mechanisms and multiple functions of somatodendritic A-type K+ channel auxiliary subunits

(2014) Henry H. Jerng et al.   Frontiers in Cellular Neuroscience

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent

(2014) Hua Huang et al.   Nature Communications

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators

(2014) Nadine J. Ortner et al.   Nature Communications

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

(2014) Mathieu Bourdenx et al.   Frontiers in Neuroanatomy

Calbindin content and differential vulnerability of midbrain efferent dopaminergic neurons in macaques

(2014) Iria G. Dopeso-Reyes et al.   Frontiers in Neuroanatomy

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

(2014) Lars Brichta et al.   Frontiers in Neuroanatomy

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?

(2014) Alexander Dietrich et al.   Cells

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration

(2013) L D Osellame et al.   BRITISH JOURNAL OF PHARMACOLOGY

KATP-Channel-Dependent Regulation of Catecholaminergic Neurons Controls BAT Sympathetic Nerve Activity and Energy Homeostasis

(2013) Sulay Tovar et al.   Cell Metabolism

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Na+/K+-ATPase by neuron-specific transcription factor Sp4: implication in the tight coupling of energy production, neuronal activity and energy consumption in neurons

(2013) Kaid Johar et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease

(2013) Patrick P. Michel et al.   FASEB JOURNAL

Calcium Channels and Short-term Synaptic Plasticity

(2013) William A. Catterall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationship of N,N′-Disubstituted Pyrimidinetriones as CaV1.3 Calcium Channel-Selective Antagonists for Parkinson’s Disease

(2013) Soosung Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

(2013) Giulia Ambrosi et al.   JOURNAL OF NEURAL TRANSMISSION

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

New Insights into the Specificity and Plasticity of Reward and Aversion Encoding in the Mesolimbic System

(2013) S. F. Volman et al.   JOURNAL OF NEUROSCIENCE

Cocaine Drives Aversive Conditioning via Delayed Activation of Dopamine-Responsive Habenular and Midbrain Pathways

(2013) T. C. Jhou et al.   JOURNAL OF NEUROSCIENCE

DREAM Controls the On/Off Switch of Specific Activity-Dependent Transcription Pathways

(2013) Britt Mellström et al.   MOLECULAR AND CELLULAR BIOLOGY

The genetics of Parkinson's disease: Progress and therapeutic implications

(2013) Andrew B. Singleton et al.   MOVEMENT DISORDERS

Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD)

(2013)   MOVEMENT DISORDERS

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

KATP channels and islet hormone secretion: new insights and controversies

(2013) Frances M. Ashcroft et al.   Nature Reviews Endocrinology

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

KATP Channel Opener Diazoxide Prevents Neurodegeneration: A New Mechanism of Action via Antioxidative Pathway Activation

(2013) Noemí Virgili et al.   PLoS One

Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease: Fig. 1.

(2013) Anthony H. V. Schapira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

(2013) S. Janezic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared dysregulated pathways lead to Parkinson's disease and diabetes

(2013) Jose A. Santiago et al.   TRENDS IN MOLECULAR MEDICINE

Control of neuronal voltage-gated calcium ion channels from RNA to protein

(2013) Diane Lipscombe et al.   TRENDS IN NEUROSCIENCES

Dissecting the diversity of midbrain dopamine neurons

(2013) Jochen Roeper   TRENDS IN NEUROSCIENCES

The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease

(2013) Eleftheria K. Pissadaki et al.   Frontiers in Computational Neuroscience

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Physiological Phenotype and Vulnerability in Parkinson's Disease

(2013) D. J. Surmeier et al.   Cold Spring Harbor Perspectives in Medicine

Use of Calcium Channel Blockers and Parkinson’s Disease

(2012) Björn Pasternak et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling

(2012) Patricia Gómez-Suaga et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2

(2012) Youren Tong et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ambroxol as a pharmacological chaperone for mutant glucocerebrosidase

(2012) Inna Bendikov-Bar et al.   BLOOD CELLS MOLECULES AND DISEASES

Calcium Signaling: Deciphering the Calcium–NFAT Pathway

(2012) James W. Putney   CURRENT BIOLOGY

Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea

(2012) S. Seino   DIABETOLOGIA

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease

(2012) D. James Surmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

(2012) Senthil Selvaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia

(2012) K. Del Tredici et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Diabetes and risk of Parkinson's disease

(2012) Emanuele Cereda et al.   MOVEMENT DISORDERS

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2012) David Sulzer et al.   MOVEMENT DISORDERS

Parkinson's disease: Evidence for environmental risk factors

(2012) Karl Kieburtz et al.   MOVEMENT DISORDERS

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Bursting for exploration

(2012) Joaquim Alves da Silva et al.   NATURE NEUROSCIENCE

Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons

(2012) Pablo Henny et al.   NATURE NEUROSCIENCE

K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration

(2012) Julia Schiemann et al.   NATURE NEUROSCIENCE

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Clinical features of Parkinson disease when onset of diabetes came first: A case-control study

(2012) E. Cereda et al.   NEUROLOGY

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

(2012) Mark L. Wahlqvist et al.   PARKINSONISM & RELATED DISORDERS

Endoplasmic reticulum–mitochondria coupling: local Ca2+ signalling with functional consequences

(2012) Daniel Bakowski et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of prefrontal cortex and the midbrain dopamine system in working memory updating

(2012) K. D'Ardenne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Dynamics and Apoptosis--the ER Connection

(2012) S. Hoppins et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

A new control center for dopaminergic systems: pulling the VTA by the tail

(2012) Romain Bourdy et al.   TRENDS IN NEUROSCIENCES

Are you or aren’t you? Challenges associated with physiologically identifying dopamine neurons

(2012) Mark A. Ungless et al.   TRENDS IN NEUROSCIENCES

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

(2012) Soosung Kang et al.   Nature Communications

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

Dihydropyridine calcium channel blockers and the progression of parkinsonism

(2011) Connie Marras et al.   ANNALS OF NEUROLOGY

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Mitochondria and Programmed Cell Death in Parkinson's Disease: Apoptosis and Beyond

(2011) Celine Perier et al.   ANTIOXIDANTS & REDOX SIGNALING

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ca2+-dependent modulation of voltage-gated Ca2+ channels

(2011) Carl Christel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Multiple Biological Pathways Link Cognitive Lifestyle to Protection from Dementia

(2011) Michael J. Valenzuela et al.   BIOLOGICAL PSYCHIATRY

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Functional organization of dendritic Ca2+ signals in midbrain dopamine neurons

(2011) Miae Jang et al.   CELL CALCIUM

Dopamine Receptor Interacting Proteins: Targeting Neuronal Calcium Sensor-1/D2 Dopamine Receptor Interaction for Antipsychotic Drug Development

(2011) Nadine Kabbani et al.   CURRENT DRUG TARGETS

A selectionist account of de novo action learning

(2011) Rui M Costa   CURRENT OPINION IN NEUROBIOLOGY

Diabetes and the Risk of Developing Parkinson's Disease in Denmark

(2011) E. Schernhammer et al.   DIABETES CARE

After half a century mitochondrial calcium in- and efflux machineries reveal themselves

(2011) Ilaria Drago et al.   EMBO JOURNAL

Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+

(2011) Damien Toulorge et al.   FASEB JOURNAL

Leucine Zipper EF Hand-containing Transmembrane Protein 1 (Letm1) and Uncoupling Proteins 2 and 3 (UCP2/3) Contribute to Two Distinct Mitochondrial Ca2+Uptake Pathways

(2011) Markus Waldeck-Weiermair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Milestones in PD genetics

(2011) Thomas Gasser et al.   MOVEMENT DISORDERS

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

(2011) Timothy J. Collier et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine release in the basal ganglia

(2011) M.E. Rice et al.   NEUROSCIENCE

Building the DREAM interactome

(2011) Marcos Rivas et al.   Science China-Life Sciences

Exploring the link between glucocerebrosidase mutations and parkinsonism

(2011) Wendy Westbroek et al.   TRENDS IN MOLECULAR MEDICINE

Vulnerability of mesostriatal dopaminergic neurons in Parkinson’s disease

(2011) Tomás González-Hernández   Frontiers in Neuroanatomy

Past, Present, and Future of the Pathophysiological Model of the Basal Ganglia

(2011) José A. Obeso et al.   Frontiers in Neuroanatomy

How Modeling Can Reconcile Apparently Discrepant Experimental Results: The Case of Pacemaking in Dopaminergic Neurons

(2011) Guillaume Drion et al.   PLoS Computational Biology

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

(2010) Dalton James Surmeier et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuronal Calcium Homeostasis and Dysregulation

(2010) Marc Gleichmann et al.   ANTIOXIDANTS & REDOX SIGNALING

New Uses for Old Drugs: Neonatal Diabetes and Sulphonylureas

(2010) Frances M. Ashcroft   Cell Metabolism

Exploring the function and pharmacotherapeutic potential ­of voltage-gated Ca2+channels with gene-knockout models

(2010) Jörg Striessnig et al.   Channels

Complex I: Inhibitors, inhibition and neurodegeneration

(2010) A.H.V. Schapira   EXPERIMENTAL NEUROLOGY

KATP channel blockade protects midbrain dopamine neurons by repressing a glia-to-neuron signaling cascade that ultimately disrupts mitochondrial calcium homeostasis

(2010) Damien Toulorge et al.   JOURNAL OF NEUROCHEMISTRY

Hyperexcitable Substantia Nigra Dopamine Neurons in PINK1- and HtrA2/Omi-Deficient Mice

(2010) Matthew W. Bishop et al.   JOURNAL OF NEUROPHYSIOLOGY

Ca2+ Influx through NMDA-Gated Channels Activates ATP-Sensitive K+ Currents through a Nitric Oxide-cGMP Pathway in Subthalamic Neurons

(2010) K.-Z. Shen et al.   JOURNAL OF NEUROSCIENCE

Pacemaking in Dopaminergic Ventral Tegmental Area Neurons: Depolarizing Drive from Background and Voltage-Dependent Sodium Conductances

(2010) Z. M. Khaliq et al.   JOURNAL OF NEUROSCIENCE

Control of Extracellular Dopamine at Dendrite and Axon Terminals

(2010) C. P. Ford et al.   JOURNAL OF NEUROSCIENCE

SYMPOSIUM REVIEW: The role of the KATPchannel in glucose homeostasis in health and disease: more than meets the islet

(2010) James S. McTaggart et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tolerability of isradipine in early Parkinson's disease: A pilot dose escalation study

(2010) Tanya Simuni et al.   MOVEMENT DISORDERS

Start/stop signals emerge in nigrostriatal circuits during sequence learning

(2010) Xin Jin et al.   NATURE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

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Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

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Muscle KATP Channels: Recent Insights to Energy Sensing and Myoprotection

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Cav1.3 Channel Voltage Dependence, Not Ca2+ Selectivity, Drives Pacemaker Activity and Amplifies Bursts in Nigral Dopamine Neurons

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

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Human Substantia Nigra Neurons Encode Unexpected Financial Rewards

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Sulfonylurea Receptor 1 Subunits of ATP-Sensitive Potassium Channels and Myocardial Ischemia/Reperfusion Injury

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(2009) Roy A. Wise   TRENDS IN NEUROSCIENCES

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(2008) Amy K. Reeve et al.   AMERICAN JOURNAL OF HUMAN GENETICS

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(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Ambroxol: A CNS Drug?

(2008) Thomas Weiser   CNS Neuroscience & Therapeutics

Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation

(2008) E. Samuels et al.   Current Neuropharmacology

SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta

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Mitochondrial alterations in Parkinson’s disease: new clues

(2008) Miquel Vila et al.   JOURNAL OF NEUROCHEMISTRY

p75 Neurotrophin Receptor Mediates Neuronal Cell Death by Activating GIRK Channels through Phosphatidylinositol 4,5-Bisphosphate

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(2008) Anthony HV Schapira   LANCET NEUROLOGY

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(2008) C. Becker et al.   NEUROLOGY

Unique Properties of Mesoprefrontal Neurons within a Dual Mesocorticolimbic Dopamine System

(2008) Stephan Lammel et al.   NEURON

Modeling KATP channel gating and its regulation

(2008) Peter Proks et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

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Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology