Neuronal calcium signaling: function and dysfunction

Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics

(2013) Tito Calì et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Nuclear calcium signalling in the regulation of brain function

(2013) Hilmar Bading   NATURE REVIEWS NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

The mitochondrial permeability transition pore: a mystery solved?

(2013) Paolo Bernardi   Frontiers in Physiology

Pathophysiology of Migraine

(2012) Daniela Pietrobon et al.   Annual Review of Physiology

Calcium channels and migraine

(2012) Daniela Pietrobon   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Mitochondrial Ca2+ and neurodegeneration

(2012) Tito Calì et al.   CELL CALCIUM

The permeability transition pore as a Ca2+ release channel: New answers to an old question

(2012) Paolo Bernardi et al.   CELL CALCIUM

Calcium Signaling: Deciphering the Calcium–NFAT Pathway

(2012) James W. Putney   CURRENT BIOLOGY

Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease

(2012) Olga Corti et al.   CURRENT OPINION IN NEUROBIOLOGY

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Hair cells, plasma membrane Ca2+ ATPase and deafness

(2012) Marta Giacomello et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease

(2012) D. James Surmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity

(2012) Gaofeng Dong et al.   JOURNAL OF NEUROCHEMISTRY

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

(2012) N. Bernard-Marissal et al.   JOURNAL OF NEUROSCIENCE

Regulation of mitochondrial permeability transition pore by PINK1

(2012) Clement A Gautier et al.   Molecular Neurodegeneration

Mg2+ Block of Drosophila NMDA Receptors Is Required for Long-Term Memory Formation and CREB-Dependent Gene Expression

(2012) Tomoyuki Miyashita et al.   NEURON

Mitochondria, calcium-dependent neuronal death and neurodegenerative disease

(2012) Michael R. Duchen   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Mutation of plasma membrane Ca2+ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca2+ homeostasis

(2012) G. Zanni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of astroglial purinergic signalling

(2012) Heike Franke et al.   Purinergic Signalling

Immunodeficiency due to defects in store-operated calcium entry

(2011) Stefan Feske   Annals of the New York Academy of Sciences

Mitochondria and Programmed Cell Death in Parkinson's Disease: Apoptosis and Beyond

(2011) Celine Perier et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism

(2011) Herman Moreno et al.   HIPPOCAMPUS

Plasma Membrane Calcium Pump (PMCA4)-Neuronal Nitric-oxide Synthase Complex Regulates Cardiac Contractility through Modulation of a Compartmentalized Cyclic Nucleotide Microdomain

(2011) Tamer M. A. Mohamed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

(2011) B. Heeman et al.   JOURNAL OF CELL SCIENCE

Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel α1C-subunit gene (Cacna1c) by DREAM translocation

(2011) Jarkko J. Ronkainen et al.   JOURNAL OF PHYSIOLOGY-LONDON

DREAM Regulates BDNF-Dependent Spinal Sensitization

(2011) Ivan Rivera-Arconada et al.   Molecular Pain

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signaling in neural development

(2011) Herbert Zimmermann   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease

(2010) Simonetta Camandola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraine

(2010) Neslihan N. Tavraz et al.   Channels

Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by ExtrasynapticN-Methyl-d-aspartate Receptors

(2010) Oliver Dick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Novel PMCA2 Pump MutationTommyImpairs Cytosolic Calcium Clearance in Hair Cells and Links to Deafness in Mice

(2010) Mario Bortolozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroid

(2010) Ming Lu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit

(2010) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reduced expression of the Ca2+transporter protein PMCA2 slows Ca2+dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination

(2010) Ruth M. Empson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Do astrocytes really exocytose neurotransmitters?

(2010) Nicola B. Hamilton et al.   NATURE REVIEWS NEUROSCIENCE

Inositol trisphosphate receptor Ca2+ release channels in neurological diseases

(2010) J. Kevin Foskett   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Purinergic signalling is involved in the malaria parasite Plasmodium falciparum invasion to red blood cells

(2010) Julio Levano-Garcia et al.   Purinergic Signalling

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Mitophagy: the latest problem for Parkinson's disease

(2010) Cristofol Vives-Bauza et al.   TRENDS IN MOLECULAR MEDICINE

New structure enlivens interest in P2X receptors

(2010) Liam E. Browne et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

IP3 Receptors: Toward Understanding Their Activation

(2010) C. W. Taylor et al.   Cold Spring Harbor Perspectives in Biology

The Plasma Membrane Ca2+ ATPase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium

(2010) M. Brini et al.   Cold Spring Harbor Perspectives in Biology

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death

(2010) G Burnstock et al.   Cell Death & Disease

DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory

(2010) Long-Jun Wu et al.   Molecular Brain

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

(2009) Manoj Jaiswal et al.   BMC NEUROSCIENCE

Molecular genetics of migraine

(2009) Boukje de Vries et al.   HUMAN GENETICS

Frequenin/NCS-1 and the Ca2+-channel  1-subunit co-regulate synaptic transmission and nerve-terminal growth

(2009) J. S. Dason et al.   JOURNAL OF CELL SCIENCE

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

(2009) Lucia Brunello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Spine neck geometry determines spino-dendritic cross-talk in the presence of mobile endogenous calcium binding proteins

(2009) Hartmut Schmidt et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

α-Synuclein modulation of Ca2+signaling in human neuroblastoma (SH-SY5Y) cells

(2009) Nishani T. Hettiarachchi et al.   JOURNAL OF NEUROCHEMISTRY

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux

(2009) Roberta Marongiu et al.   JOURNAL OF NEUROCHEMISTRY

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Glutamate Transporter Coupling to Na,K-ATPase

(2009) E. M. Rose et al.   JOURNAL OF NEUROSCIENCE

The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning

(2009) J. C. Alexander et al.   LEARNING & MEMORY

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

(2009) Antony Galione et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium hypothesis of Alzheimer’s disease

(2009) Michael J. Berridge   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium Pumps in Health and Disease

(2009) Marisa Brini et al.   PHYSIOLOGICAL REVIEWS

Intracellular Ca2+ signaling and store-operated Ca2+ entry are required in Drosophila neurons for flight

(2009) G. Venkiteswaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

(2009) A. Berna-Erro et al.   Science Signaling

Purinergic signalling in inflammation of the central nervous system

(2009) Francesco Di Virgilio et al.   TRENDS IN NEUROSCIENCES

A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk

(2008) Ute Dreses-Werringloer et al.   CELL

The continuing disappearance of “pure” Ca2+ buffers

(2008) B. Schwaller   CELLULAR AND MOLECULAR LIFE SCIENCES

Lack of DREAM Protein Enhances Learning and Memory and Slows Brain Aging

(2008) Ángela Fontán-Lozano et al.   CURRENT BIOLOGY

Diverse Functional Consequences of Mutations in the Na+/K+-ATPase α2-Subunit Causing Familial Hemiplegic Migraine Type 2

(2008) Neslihan N. Tavraz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolated CytochromecOxidase Deficiency in G93A SOD1 Mice Overexpressing CCS Protein

(2008) Marjatta Son et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

(2008) José R. Lopez et al.   JOURNAL OF NEUROCHEMISTRY

Self-Limited Hyperexcitability: Functional Effect of a Familial Hemiplegic Migraine Mutation of the Nav1.1 (SCN1A) Na+ Channel

(2008) S. Cestele et al.   JOURNAL OF NEUROSCIENCE

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3

(2008) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Cu/Zn Superoxide Dismutase Typical for Familial Amyotrophic Lateral Sclerosis Increases the Vulnerability of Mitochondria and Perturbs Ca2+ Homeostasis in SOD1G93A Mice

(2008) M. K. Jaiswal et al.   MOLECULAR PHARMACOLOGY

Calcium Channel Regulation and Presynaptic Plasticity

(2008) William A. Catterall et al.   NEURON

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Metabotropic Glutamate Receptor-Mediated LTD Involves Two Interacting Ca2+ Sensors, NCS-1 and PICK1

(2008) Jihoon Jo et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

P2X receptors and synaptic plasticity

(2008) Y. Pankratov et al.   NEUROSCIENCE

Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity

(2008) Rebekah Corlew et al.   NEUROSCIENTIST

Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models

(2008) Britt Mellström et al.   PHYSIOLOGICAL REVIEWS

Divergent sodium channel defects in familial hemiplegic migraine

(2008) K. M. Kahlig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels

(2008) K. Watase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

The Novel Mouse Mutation Oblivion Inactivates the PMCA2 Pump and Causes Progressive Hearing Loss

(2008) Sarah L. Spiden et al.   PLoS Genetics

Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca2+

(2007) Shidi Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis

(2003) David R. Beers et al.   JOURNAL OF NEUROCHEMISTRY