Calcium signaling in Parkinson’s disease

Neuronal calcium signaling: function and dysfunction

(2014) Marisa Brini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkinson’s disease is associated with altered expression of CaV1 channels and calcium-binding proteins

(2013) Michael J. Hurley et al.   BRAIN

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Calcium and Endoplasmic Reticulum-Mitochondria Tethering in Neurodegeneration

(2013) Tito Calì et al.   DNA AND CELL BIOLOGY

The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

(2013) Fumika Koyano et al.   GENES TO CELLS

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Physiological Roles

(2013) Maria Patron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

The many faces of alpha-synuclein mutations

(2013) Meike Kasten et al.   MOVEMENT DISORDERS

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity

(2013) Katerina Melachroinou et al.   NEUROBIOLOGY OF AGING

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Continuously Tunable Ca2+ Regulation of RNA-Edited CaV1.3 Channels

(2013) Hojjat Bazzazi et al.   Cell Reports

Physiological Phenotype and Vulnerability in Parkinson's Disease

(2013) D. J. Surmeier et al.   Cold Spring Harbor Perspectives in Medicine

Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways

(2013) M. R. Cookson   Cold Spring Harbor Perspectives in Medicine

Use of Calcium Channel Blockers and Parkinson’s Disease

(2012) Björn Pasternak et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

(2012) Salvatore J. Cherra et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Ca2+ and neurodegeneration

(2012) Tito Calì et al.   CELL CALCIUM

The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson’s disease models

(2012) S Büttner et al.   CELL DEATH AND DIFFERENTIATION

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

(2012) Igor F. Tsigelny et al.   FEBS Journal

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease

(2012) D. James Surmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease

(2012) Zhi Yao et al.   JOURNAL OF CELL SCIENCE

In Vivo Alterations in Calcium Buffering Capacity in Transgenic Mouse Model of Synucleinopathy

(2012) L. Reznichenko et al.   JOURNAL OF NEUROSCIENCE

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Mitophagy and Parkinson's disease: Be eaten to stay healthy

(2012) Rosa L.A. de Vries et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL

(2012) Haigang Ren et al.   Molecular Neurodegeneration

Regulation of mitochondrial permeability transition pore by PINK1

(2012) Clement A Gautier et al.   Molecular Neurodegeneration

Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease

(2012) Joshua A Goldberg et al.   NATURE NEUROSCIENCE

A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds

(2012) Jesse H Goldberg et al.   NATURE NEUROSCIENCE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

RNA Editing of the IQ Domain in Cav1.3 Channels Modulates Their Ca2+-Dependent Inactivation

(2012) Hua Huang et al.   NEURON

Potassium Depolarization and Raised Calcium Induces α-Synuclein Aggregates

(2012) Jordan Follett et al.   NEUROTOXICITY RESEARCH

Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease

(2012) Sonia Gandhi et al.   PLoS One

Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes

(2012) Felix Schmidt et al.   PLoS One

Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

(2012) Emilie Giaime et al.   PLoS One

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

The use of transgenic mouse models to reveal the functions of Ca2+ buffer proteins in excitable cells

(2011) Beat Schwaller   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease

(2011) Tito Calì et al.   BIOFACTORS

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Oxidized DJ-1 Interacts with the Mitochondrial Protein BCL-XL

(2011) Haigang Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

(2011) B. Heeman et al.   JOURNAL OF CELL SCIENCE

α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis

(2011) Zhengxin Ying et al.   JOURNAL OF NEURAL TRANSMISSION

Mitochondrial Pathology in Parkinson's Disease

(2011) Anthony H. V. Schapira   MOUNT SINAI JOURNAL OF MEDICINE

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

(2011) Timothy J. Collier et al.   NATURE REVIEWS NEUROSCIENCE

Initial Motor Symptoms of Parkinson Disease

(2011) Pedro J. Garcia Ruiz et al.   NEUROLOGIST

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease

(2011) Andrey Yurevich Abramov et al.   PLoS One

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

(2011) F. H. Sterky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Neural Mechanisms for Interacting with a World Full of Action Choices

(2010) Paul Cisek et al.   Annual Review of Neuroscience

The Role of Cysteine Oxidation in DJ-1 Function and Dysfunction

(2010) Mark A. Wilson   ANTIOXIDANTS & REDOX SIGNALING

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization

(2010) Victor S. Van Laar et al.   HUMAN MOLECULAR GENETICS

Pacemaking in Dopaminergic Ventral Tegmental Area Neurons: Depolarizing Drive from Background and Voltage-Dependent Sodium Conductances

(2010) Z. M. Khaliq et al.   JOURNAL OF NEUROSCIENCE

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Cortical and Thalamic Innervation of Direct and Indirect Pathway Medium-Sized Spiny Neurons in Mouse Striatum

(2010) N. M. Doig et al.   JOURNAL OF NEUROSCIENCE

Raised calcium promotes α-synuclein aggregate formation

(2010) S. Nath et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

NAADP Receptors

(2010) A. Galione   Cold Spring Harbor Perspectives in Biology

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Occupation and Risk of Parkinsonism

(2009) Caroline M. Tanner et al.   ARCHIVES OF NEUROLOGY

The human brain in numbers: a linearly scaled-up primate brain

(2009) Suzana Herculano-Houzel   Frontiers in Human Neuroscience

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

α-Synuclein modulation of Ca2+signaling in human neuroblastoma (SH-SY5Y) cells

(2009) Nishani T. Hettiarachchi et al.   JOURNAL OF NEUROCHEMISTRY

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux

(2009) Roberta Marongiu et al.   JOURNAL OF NEUROCHEMISTRY

Steven M. Platek, Julian Paul Keenan and Todd K. Shackelford (eds), Evolutionary Cognitive Neuroscience

(2009) Mitch Parsell   MINDS AND MACHINES

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

Altered Ca2+ homeostasis in the skeletal muscle of DJ−1 null mice

(2009) Alexander Shtifman et al.   NEUROBIOLOGY OF AGING

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease

Pesticide exposure and risk of Parkinson's disease: A family-based case-control study

(2008) Dana B Hancock et al.   BMC Neurology

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

The history of dopamine and levodopa in the treatment of Parkinson's disease

(2008) Stanley Fahn   MOVEMENT DISORDERS

Use of antihypertensives and the risk of Parkinson disease

(2008) C. Becker et al.   NEUROLOGY

Striatal Plasticity and Basal Ganglia Circuit Function

(2008) Anatol C. Kreitzer et al.   NEURON

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING

Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain

(2004) Rachel Lowe et al.   PROTEIN SCIENCE